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Year-Round Allergies

(Perennial Allergies)

By Peter J. Delves, PhD, Professor of Immunology, Division of Infection & Immunity, Faculty of Medical Sciences, University College London, London, UK

Year-round (perennial) allergies result from exposure to airborne substances (such as house dust) that are present throughout the year.

  • The nose is congested, itchy, and sometimes runny, and the mouth and throat are itchy.

  • The symptoms and activities that trigger the allergy usually suggest the diagnosis.

  • Avoiding the allergen is best, but drugs, such as antihistamines, can help relieve symptoms.

Perennial allergies may occur at any time of year—unrelated to the season—or may last year-round. Perennial allergies are often a reaction to house dust. House dust may contain mold and fungal spores, fibers of fabric, animal dander, dust mite droppings, and bits of insects. Substances in and on cockroaches are often the cause of allergic symptoms. These substances are present in houses year-round but may cause more severe symptoms during the cold months when more time is spent indoors.

Usually, perennial allergies cause nasal symptoms (allergic rhinitis) but not eye symptoms (allergic conjunctivitis). However, allergic conjunctivitis can result when certain substances are purposely or inadvertently placed in the eyes. These substances include drugs used to treat eye disorders, cosmetics such as eyeliner and face powder, and hair dye. The cleaning solutions for contact lenses can cause an allergic reaction.

Perennial rhinitis is often caused by something other than an allergy, such as aspirin or another nonsteroidal anti-inflammatory drug (NSAID) or another form of rhinitis.

Did You Know...

  • Cockroaches are often to blame for year-round allergies.


The most obvious symptom of perennial allergies is a chronically stuffy nose. The nose runs, producing a clear watery discharge. The nose, roof of the mouth, and back of the throat may itch. Itching may start gradually or abruptly. Sneezing is common.

The eustachian tube, which connects the middle ear and the back of the nose, may become swollen. As a result, hearing can be impaired, especially in children. Children may also develop chronic ear infections. Some people have recurring sinus infections (chronic sinusitis) and growths inside the nose (nasal polyps).

When affected, the eyes water and itch. The whites of the eyes may become red, and the eyelids may become red and swollen.

Many people who have a perennial allergy also have asthma, possibly caused by the same allergy triggers (allergens) that contribute to allergic rhinitis and allergic conjunctivitis.


  • A doctor's evaluation

Diagnosis of perennial allergies is based on symptoms plus the circumstances in which they occur—that is, in response to certain activities, such as petting a cat.

Allergy testing

Tests are needed only if people do not respond to treatment.

In such cases, skin prick tests can help confirm the diagnosis and identify the trigger for symptoms (such as dust mites or cockroaches). For these tests, a drop of each extract is placed on the person’s skin, which is then pricked with a needle. Doctors then watch to see if there is a wheal-and-flare reaction (a pale, slightly elevated swelling surrounded by a red area).

An allergen-specific immunoglobulin (IgE) test is done if results of the skin test are unclear. For this test, a sample of blood is withdrawn and tested.


Avoiding the allergen, if possible, is recommended, thus preventing the development of symptoms.

If people are allergic to house dust, some changes in the environment can prevent or lessen symptoms:

  • Removing items that collect dust, such as knickknacks, magazines, and books

  • Replacing upholstered furniture or vacuuming it frequently

  • Replacing draperies and shades with blinds

  • Removing carpets or replacing them with throw rugs

  • Frequently washing bed sheets, pillowcases, and blankets in hot water

  • Treating homes with heat-steam

  • Covering mattresses and pillows with finely woven fabrics that cannot be penetrated by dust mites and allergen particles

  • Using synthetic-fiber pillows

  • Frequently cleaning the house, including dusting, vacuuming, and wet-mopping

  • Using air conditioners and dehumidifiers to reduce the high indoor humidity that encourages the breeding of dust mites

  • Using high-efficiency particulate air (HEPA) vacuums and filters

  • Exterminating cockroaches

If a person is allergic to animal dander, the family pet may be limited to certain rooms of the house or, if possible, kept out of the house. Washing the pet weekly can also help.


  • Corticosteroid nasal sprays

  • Antihistamines

  • Decongestants

  • Sometimes allergen immunotherapy

  • For nasal polyps, sometimes surgery

Avoiding the allergen is the best way to treat as well as prevent allergies.

Drug treatment of perennial allergies is similar to that for seasonal allergies. It includes corticosteroid nasal sprays, antihistamines, and decongestants.

A corticosteroid nasal spray is usually very effective and is used first. Most of these sprays have few side effects, although they can cause nosebleeds and a sore nose.

An antihistamine, taken by mouth or used as a nasal spray, can be used instead of or in addition to a corticosteroid nasal spray. Antihistamines are often used with a decongestant, such as pseudoephedrine, taken by mouth.

Many antihistamine-decongestant combinations are available over the counter as a single tablet. However, people with high blood pressure should not take a decongestant unless a doctor recommends it and monitors its use. Also, people who take a monoamine oxidase inhibitor (a type of antidepressant) cannot take a product that combines an antihistamine and a decongestant.

Decongestants are also available over the counter as nose drops or sprays. They should not be used for more than a few days at a time because using them continually for a week or more may worsen or prolong nasal congestion—called a rebound effect—and may eventually result in chronic congestion.

Antihistamines may have side effects, particularly anticholinergic effects. Anticholinergic effects include sleepiness, dry mouth, blurred vision, constipation, difficulty with urination, confusion, and light-headedness (see Anticholinergic: What Does It Mean?).

Side effects tend to be fewer and less severe with nasal sprays than with drugs taken by mouth.

Other drugs are sometimes useful. Cromolyn is available by prescription as a nasal spray and may help relieve a runny nose. To be effective, it must be used regularly. Azelastine (an antihistamine) and ipratropium (a drug that inhibits acetylcholine), both available by prescription as nasal sprays, may be effective. But these drugs can have anticholinergic effects similar to those of antihistamines taken by mouth, especially drowsiness.

Montelukast, a leukotriene modifier available by prescription, reduces inflammation and helps relieve a runny nose. But how it is best used has not been established.

Regularly flushing out the sinuses with a warm water and salt (saline) solution may help loosen and wash out mucus and hydrate the nasal lining. This technique is called sinus irrigation.

When these treatments are ineffective, a corticosteroid may be taken by mouth or by injection for a short time (usually for fewer than 10 days). If taken by mouth or injection for a long time, corticosteroids can have serious side effects (see Corticosteroids: Uses and Side Effects).

Allergen immunotherapy (desensitization)

If other treatments are ineffective, allergen immunotherapy helps some people.

Immunotherapy is needed in the following situations:

  • When symptoms are severe

  • When the allergen cannot be avoided

  • When the drugs usually used to treat allergic rhinitis or conjunctivitis cannot control symptoms

  • If asthma develops


For people with chronic sinusitis and nasal polyps, surgery is sometimes needed to improve sinus drainage and remove infected material or to remove the polyps. Before and after surgery, regular sinus irrigation may be helpful.

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