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By Hans P. Schlecht, MD, MSc, Assistant Professor of Medicine, Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine ; Christopher Bruno, MD, Assistant Professor of Medicine, Division of infectious Diseases & HIV Medicine, Drexel University College of Medicine

The antibiotic daptomycin is used to treat many serious bacterial infections, such as those caused by gram-positive bacteria, including those that are resistant to many other antibiotics.

Daptomycin works by interfering with the bacteria's production of the genetic material and proteins needed to grow and multiply.


Common Uses

Some Side Effects


Complicated skin infections, bloodstream infections, and certain heart valve infections (endocarditis) due to susceptible bacteria, including methicillin-resistant Staphylococcus aureus (MRSA)

Gastrointestinal upset

Muscle pain and weakness

Not used when infection involves the lungs*

*Daptomycin does not work well in the lungs and may cause lung inflammation unrelated to infection.

Use of Daptomycin During Pregnancy and Breastfeeding

Daptomycin should be used during pregnancy only when the benefits of treatment outweigh the risks.

Whether daptomycin is safe to use during breastfeeding is unknown.

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