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Quinupristin and Dalfopristin

By Hans P. Schlecht, MD, MSc, Assistant Professor of Medicine, Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine
Christopher Bruno, MD, Assistant Professor of Medicine, Division of infectious Diseases & HIV Medicine, Drexel University College of Medicine

Quinupristin and dalfopristin belong to a class of antibiotics called streptogramins. These drugs are given together as a combination (quinupristin/dalfopristin). They are used to treat serious infections (especially skin infections), including those caused by bacteria resistant to other antibiotics.

Quinupristin/dalfopristin works by preventing bacteria from producing proteins they need to grow and multiply.

Quinupristin/dalfopristin is given intravenously, usually through a tube (catheter) inserted into a large central vein, such as one in the neck, or into a vein in the upper arm and threaded to a large central vein. This type of catheter is called a central catheter.


Common Uses

Some Side Effects

Serious infections caused by gram-positive bacteria (such as Staphylococcus and Streptococcus species) that are resistant to other antibiotics

Aching muscles and joints

Increased bilirubin* in blood

Pain and inflammation at the site where the catheter was inserted

*Bilirubin is a waste product that is formed during the normal breakdown of red blood cells. Bilirubin is processed in, then excreted out of the liver.

Use of Quinupristin/Dalfopristin During Pregnancy and Breastfeeding

Quinupristin/dalfopristin should be used during pregnancy only when the benefits of treatment outweigh the risks.

Whether use of quinupristin/dalfopristin during breastfeeding is safe is not known.

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