Spontaneous abortion is noninduced embryonic or fetal death or passage of products of conception before 20 wk gestation. Threatened abortion is vaginal bleeding without cervical dilation occurring during this time frame and indicating that spontaneous abortion may occur in a woman with a confirmed viable intrauterine pregnancy. Diagnosis is by clinical criteria and ultrasonography. Treatment is usually expectant observation for threatened abortion and, if spontaneous abortion has occurred or appears unavoidable, observation or uterine evacuation.
Fetal death and early delivery are classified as follows:
Abortion: Death of the fetus or passage of products of conception (fetus and placenta) before 20 wk gestation
Fetal demise (stillbirth): Fetal death after 20 wk
Preterm delivery: Passage of a live fetus between 20 and 37 wk (see Preterm Labor)
Abortions may be classified as early or late, spontaneous or induced for therapeutic or elective reasons (see Induced Abortion), threatened or inevitable, incomplete or complete, recurrent (also called recurrent pregnancy loss—see Recurrent Pregnancy Loss), missed, or septic (see Table: Classification of Abortion).
Classification of Abortion
About 20 to 30% of women with confirmed pregnancies bleed during the first 20 wk of pregnancy; half of these women spontaneously abort. Thus, incidence of spontaneous abortion is about 10 to 15% in confirmed pregnancies. Incidence in all pregnancies is probably higher because some very early abortions are mistaken for a late menstrual period.
Isolated spontaneous abortions may result from certain viruses—most notably cytomegalovirus, herpesvirus, parvovirus, and rubella virus—or from disorders that can cause sporadic abortions or recurrent pregnancy loss (eg, chromosomal or mendelian abnormalities, luteal phase defects). Other causes include immunologic abnormalities, major trauma, and uterine abnormalities (eg, fibroids, adhesions). Most often, the cause is unknown.
Risk factors include
Subclinical thyroid disorders, a retroverted uterus, and minor trauma have not been shown to cause spontaneous abortions.
Symptoms include crampy pelvic pain, bleeding, and eventually expulsion of tissue. Late spontaneous abortion may begin with a gush of fluid when the membranes rupture. Hemorrhage is rarely massive. A dilated cervix indicates that abortion is inevitable.
If products of conception remain in the uterus after spontaneous abortion, vaginal bleeding may occur, sometimes after a delay of hours to days. Infection may also develop, causing fever, pain, and sometimes sepsis.
Diagnosis of threatened, inevitable, incomplete, or complete abortion is often possible based on clinical criteria (see Table: Characteristic Symptoms and Signs in Spontaneous Abortions) and a positive urine pregnancy test. However, ultrasonography and quantitative measurement of serum β-hCG are usually done to exclude ectopic pregnancy and to determine whether products of conception remain in the uterus (suggesting that abortion is incomplete rather than complete). However, results may be inconclusive, particularly during early pregnancy.
Characteristic Symptoms and Signs in Spontaneous Abortions
Missed abortion is suspected if the uterus does not progressively enlarge or if quantitative β-hCG is low for gestational age or does not double within 48 to 72 h. Missed abortion is confirmed if ultrasonography shows any of the following:
Disappearance of previously detected embryonic cardiac activity
Absence of such activity when the fetal crown-rump length is > 5 mm (determined by transvaginal ultrasonography)
Absence of a fetal pole (determined by transvaginal ultrasonography) when the mean sac diameter (average of diameters measured in 3 orthogonal planes) is > 18 mm
For recurrent pregnancy loss, testing to determine the cause of abortion is necessary (see Recurrent Pregnancy Loss).
For threatened abortion, treatment is observation. No evidence suggests that bed rest decreases risk of subsequent completed abortion.
For inevitable, incomplete, or missed abortions, treatment is uterine evacuation or waiting for spontaneous passage of the products of conception. Evacuation usually involves suction curettage at < 12 wk, dilation and evacuation at 12 to 23 wk, or medical induction (for women without prior uterine surgery) at > 16 to 23 wk (for treatment of late fetal death, see Stillbirth). The later the uterus is evacuated, the greater the likelihood of placental bleeding, uterine perforation by long bones of the fetus, and difficulty dilating the cervix. These complications are reduced by preoperative use of osmotic cervical dilators (eg, laminaria), misoprostol, or mifepristone (RU 486).
If complete abortion is suspected, uterine evacuation need not be done routinely. Uterine evacuation can be done if bleeding occurs and/or if other signs indicate that products of conception may be retained.
After an induced or spontaneous abortion, parents may feel grief and guilt. They should be given emotional support and, in the case of spontaneous abortions, reassured that their actions were not the cause. Formal counseling is rarely indicated but should be made available.
Spontaneous abortion probably occurs in about 10 to 15% of pregnancies.
The cause of an isolated spontaneous abortion is usually unknown.
A dilated cervix means that abortion is inevitable.
Confirm spontaneous abortion and determine its type based on clinical criteria, ultrasonography, and quantitative β-hCG.
Uterine evacuation is eventually necessary for inevitable, incomplete, or missed abortions.
Often, uterine evacuation is not needed for threatened and complete abortions.
After spontaneous abortion, provide emotional support to the parents.
Recurrent pregnancy loss is ≥ 3 consecutive spontaneous abortions. Determining the cause may require extensive evaluation of both parents. Some causes can be treated.
Causes of recurrent pregnancy loss may be maternal, fetal, or placental.
Common maternal causes include
Uterine or cervical abnormalities (eg, polyps, myomas, adhesions, cervical insufficiency)
Maternal (or paternal) chromosomal abnormalities (eg, balanced translocations)
Luteal phase defects (particularly at < 6 wk)
Overt and poorly controlled endocrine disorders (eg, hypothyroidism, hyperthyroidism, diabetes mellitus)
Chronic renal disorders
Acquired thrombotic disorders (eg, related to antiphospholipid antibody syndrome with lupus anticoagulant, anticardiolipin [IgG or IgM], or anti-β2 glycoprotein I [IgG or IgM]) are associated with recurrent losses after 10 wk. The association with hereditary thrombotic disorders is less clear but does not appear to be strong, except for possibly factor V Leiden mutation.
Placental causes include preexisting chronic disorders that are poorly controlled (eg, SLE, chronic hypertension).
Fetal causes are usually
Chromosomal abnormalities may cause 50% of recurrent pregnancy losses; losses due to chromosomal abnormalities are more common during early pregnancy. Aneuploidy is involved in up to 80% of all spontaneous abortions occurring at < 10 wk gestation but in < 15% of those occurring at ≥ 20 wk.
Whether a history of recurrent pregnancy loss increases risk of fetal growth restriction and premature delivery in subsequent pregnancies depends on the cause of the losses.
Evaluation should include the following to help determine the cause:
Genetic evaluation (karyotyping) of both parents and any products of conception as clinically indicated to exclude possible genetic causes (see Genetic Evaluation)
Screening for acquired thrombotic disorders: Anticardiolipin antibodies (IgG and IgM), anti-β2 glycoprotein I (IgG and IgM), and lupus anticoagulant
Evaluation of ovarian reserve including measuring follicle-stimulating hormone level on day 3 of the menstrual cycle
Hysterosalpingography or sonohysterography to check for structural uterine abnormalities
Cause cannot be determined in up to 50% of women. Screening for hereditary thrombotic disorders is no longer routinely recommended unless supervised by a maternal-fetal medicine specialist.