Monobactams are parenteral β-lactam bactericidal antibiotics.
Aztreonam is currently the only available monobactam. Aztreonam is as active as ceftazidime against
Aztreonam is not active against anaerobes. Gram-positive bacteria are resistant to aztreonam (in contrast to cephalosporins). Aztreonam acts synergistically with aminoglycosides.
Because the metabolic products of aztreonam differ from those of other β-lactams, cross-hypersensitivity is unlikely. Thus, aztreonam is used mainly for
Other antibiotics are added to cover any suspected gram-positive cocci and anaerobes.
The dose is reduced in renal failure.