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Focal Segmental Glomerulosclerosis (IgM in Mesangium)

Immunofluorescence staining with anti-IgM demonstrates IgM in mesangium or in areas of hyalinosis (smooth, globular staining on right). IgM is thought to become trapped in areas of expanded mesangium and sclerosis ( × 200).

Image provided by Agnes Fogo, MD and the American Journal of Kidney Disease’s Atlas of Renal Pathology (see