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Aplastic Anemia

(Hypoplastic Anemia)

(See also Overview of Anemia.)

Aplastic anemia is a disorder in which the cells of the bone marrow that develop into mature blood cells are damaged, leading to low numbers of red blood cells, white blood cells, and/or platelets.

When the bone marrow cells that develop into mature blood cells and platelets (stem cells) are damaged or suppressed, the bone marrow can shut down. This bone marrow failure is called aplastic anemia. The bone marrow failure leads to too few red blood cells (anemia), too few white blood cells (leukopenia), and too few platelets (thrombocytopenia).

The term aplastic anemia is used to refer to anemia that occurs when production of all types of blood cells is suppressed. If production of only red blood cells is suppressed, the disorder is called pure red blood cell aplasia.

When the cause of aplastic anemia cannot be diagnosed (called idiopathic aplastic anemia), the cause is likely an autoimmune disorder, in which the immune system suppresses bone marrow stem cells.

Other causes include

  • Infection with viruses such as parvovirus, Epstein Barr virus, and cytomegalovirus

  • Radiation exposure

  • Toxins (such as benzene)

  • Chemotherapy drugs and other drugs (such as chloramphenicol)

  • Pregnancy

  • Hepatitis

Symptoms

Symptoms of aplastic anemia usually develop slowly over weeks to months.

The anemia causes fatigue, weakness, and paleness. The leukopenia causes increased susceptibility to infection. The thrombocytopenia causes easy bruising and bleeding.

Diagnosis

  • Blood tests

  • Bone marrow examination

Blood tests are done in people who have symptoms of anemia. When blood tests show that all blood cell numbers are reduced , a bone marrow examination is done.

Aplastic anemia is diagnosed when microscopic examination of a sample of bone marrow (bone marrow biopsy) reveals a sharp decrease in bone marrow cells.

Treatment

  • Stem cell transplantation

People with severe aplastic anemia may die unless immediately treated. Transfusions of red blood cells, platelets, and substances called growth factors may temporarily increase the numbers of red blood cells, white blood cells, and platelets. However, because transfusions may prevent subsequent stem cell transplantation, blood products are used only when essential.

Stem cell transplantation is the usual treatment in aplastic anemia because it may cure the disease, especially in younger people who have a matched stem cell donor. If transplantation is not possible, people are given antithymocyte globulin and cyclosporine to suppress the immune system and allow the bone marrow stem cells to regenerate.