Tongue discomfort can result from irritation by
Intense pain of the entire mouth can be caused by burning mouth syndrome.
Often it is a process of elimination to find out just what is causing the discomfort. Tongue discomfort not caused by an infection is usually treated by eliminating the cause. For example, the person may try changing brands of toothpaste (particularly to a brand that does not contain the ingredient sodium lauryl sulfate [SLS]), stop eating irritating/acidic/spicy foods, or have a sharp or broken tooth repaired by a dentist. Warm salt-water rinses may help. Thrush can be treated with an antifungal drug, such as nystatin or fluconazole.