Syphilis is a sexually transmitted disease (STD). An STD is an infection that is spread from person to person by sexual contact.
Stage 1: Syphilis starts in the part of your body that was exposed to your sex partner's body fluids. For example, if you had vaginal sex, syphilis may start on your penis (if you're a man) or in or near your vagina (if you're a woman).
Stage 2: Syphilis spreads into your blood and infects your skin.
Stage 3: Syphilis spreads throughout your body. Any body part can be infected by syphilis but particularly your heart, blood vessels, brain, and spinal cord.
There is often a gap between stage 2 and stage 3. This gap is called the latent period. During the latent period, people feel well and can't pass syphilis to other people. Sometimes syphilis stops after stage 2. However, about 1 out of 3 people go on to stage 3.
Symptoms are different in each stage of syphilis.
A small, red, raised area at the infection site, such as your penis, vagina, rectum (where poop is stored), or lips
The small red area turns into a painless, open sore that's hard and doesn’t bleed
You may not notice the sore because it doesn't cause many symptoms
3 to 12 weeks later, the sore heals and you’ll feel healthy
If not treated, syphilis will move to stage 2 because the infection spreads in your blood.
A painless rash on your body that doesn't itch—unlike most other rashes, the rash from syphilis often appears on the palms of your hands or soles of your feet
Raised, flat, smooth warts may also form on the moist areas around your mouth, armpits, sex parts, and anus (where poop comes out)
Feeling weak and tired all over
Feeling less hungry than usual
Swollen lymph nodes
The warts are full of syphilis germs. The germs can spread to people who touch the warts.
Stage 2 symptoms eventually go away. But they can cause problems with other parts of your body and organs, such as your liver, kidneys, and eyes. If not treated, you may not have any more symptoms. However, about 1 out of 3 people with syphilis will move to stage 3.
Symptoms may affect your skin, blood vessels, heart, brain, or spinal cord.
Skin problems can include:
Blood vessel problems usually involve the big artery (aorta) that comes out of the heart and carries blood to the body. The aorta may weaken and widen. Sometimes the weakened aorta splits open (ruptures), which can be fatal. An aorta problem causes:
Heart problems usually result in leaky heart valves and symptoms are:
Brain problems usually don't appear for 15 to 20 years. Symptoms include:
Spinal cord infection makes it hard to control your muscles. You might have:
To diagnose syphilis, doctors do blood tests. If they think syphilis has affected your brain or spinal cord, doctors may do a spinal tap.
Give you a shot of penicillin into one of your muscles, usually your rear end
Give you extra doses of penicillin based on your stage and symptoms
Tell you to avoid having sex until you have finished treatment
Test and treat your sex partners for syphilis
Do blood tests and exams to make sure treatment worked
People who are allergic to penicillin may be given other antibiotics.
Sometimes when the penicillin kills the syphilis germs, your body reacts to all the dead and dying germs. This reaction usually happens within the first 12 hours. You may have fever, headache, muscle aches, and a rash. This reaction is uncomfortable but not dangerous. It goes away within 24 hours. This reaction isn't due to an allergy to penicillin.