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Melatonin ˌmel-ə-ˈtō-nən

By Melissa G. Marko, PhD, Senior Clinical Scientist, Nestle Nutrition ; Ara DerMarderosian, PhD, Professor Emeritus of Biology and Pharmacognosy, University of the Sciences

Melatonin, a hormone produced by the pineal gland (located in the middle of the brain), regulates the sleep-wake cycle. Melatonin used in supplements is derived from animals or produced artificially. In some countries, melatonin is considered a drug and is regulated as such.

Medicinal claims

People use melatonin mostly to treat insomnia and to help minimize the effects of jet lag or of shift work. People who are traveling across time zones may take melatonin on the day or night of departure and for 2 or 3 nights after arrival. People who rotate work shifts may take melatonin before going to bed. Research is being conducted in using melatonin to resynchronize the sleep-wake cycle for people in the early phases of Alzheimer disease.

Evidence suggests that melatonin supplements can affect the sleep-wake cycle. However, in one well-designed study, melatonin supplements did not relieve symptoms of jet lag, and only a few small studies suggest that these supplements can treat insomnia.

Possible side effects

Drowsiness may occur 30 minutes after taking melatonin and lasts for about 1 hour. Otherwise, melatonin seems to have few short-term side effects, although headache and temporary depression have been reported. Whether melatonin is safe when used long-term is unknown. In people who are depressed, melatonin may worsen symptoms. Melatonin is best taken under medical supervision.

Possible drug interactions

Melatonin may increase effects of warfarin, increasing risk of bleeding.

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