For more information, see table and see table .
See also Approach to the Patient With a Suspected Inherited Disorder of Metabolism Approach to the Patient With a Suspected Inherited Disorder of Metabolism Most inherited disorders of metabolism (inborn errors of metabolism) are rare, and therefore their diagnosis requires a high index of suspicion. Timely diagnosis leads to early treatment and... read more .
Niemann-Pick disease inheritance is autosomal recessive Autosomal Recessive Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. If expression of a trait requires only one copy of a gene (one allele)... read more and appears most often in people of Ashkenazi Jewish ancestry; 2 types, A and B, exist. Type C Niemann-Pick disease Other Lipidoses is an unrelated enzymatic defect involving abnormal cholesterol storage.
Children with type A have < 5% of normal sphingomyelinase activity. The disease is characterized by hepatosplenomegaly, failure to thrive, and rapidly progressive neurodegeneration. Death occurs by age 2 or 3 years.
Patients with type B have sphingomyelinase activity within 5 to 10% of normal. Type B is more variable clinically than type A. Hepatosplenomegaly and lymphadenopathy may occur. Pancytopenia is common. Most patients with type B have little or no neurologic involvement, may have intellectual disability, and survive into adulthood; they may be clinically indistinguishable from those with type I Gaucher disease Gaucher Disease Gaucher disease is a sphingolipidosis, an inherited disorder of metabolism, resulting from glucocerebrosidase deficiency, causing deposition of glucocerebroside and related compounds. Symptoms... read more . In severe cases of type B, progressive pulmonary infiltrates cause major complications.
Children with type C develop symptoms usually during childhood, with seizures and neurologic deterioration. Type C is always fatal, and most children die before age 20.
Diagnosis of Niemann-Pick Disease
Prenatal screening
White blood cell sphingomyelinase assay
Both types are usually suspected by history and examination, most notably hepatosplenomegaly. Diagnosis of Niemann-Pick disease can be confirmed by DNA analysis and/or sphingomyelinase assay on white blood cells and can be made prenatally by using amniocentesis or chorionic villus sampling.
DNA tests also can be done to diagnose carriers. (See also testing for suspected inherited disorders of metabolism Initial testing Most inherited disorders of metabolism (inborn errors of metabolism) are rare, and therefore their diagnosis requires a high index of suspicion. Timely diagnosis leads to early treatment and... read more .)
Treatment of Niemann-Pick Disease
Possible bone marrow transplantation, stem cell transplantation, and enzyme replacement
Bone marrow transplantation, stem cell transplantation, and enzyme replacement are under investigation as potential treatment options.
More Information
The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
Online Mendelian Inheritance in Man (OMIM) database: Complete gene, molecular, and chromosomal location information