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Protein Disorders Causing Blood Vessel Disorders

by David J. Kuter, MD, DPhil

Conditions that cause an abnormal protein or an abnormal amount of certain normal proteins in the blood can cause blood vessels to become fragile. When these fragile blood vessels break, people develop red or purple blemishes or bruises (purpura) on the skin. Conditions that may cause purpura include

  • Amyloidosis

  • Cryoglobulinemia

  • Hypergammaglobulinemic purpura

  • Hyperviscosity syndrome


Amyloidosis (see Amyloidosis) causes the protein amyloid to be deposited within blood vessels in the skin and subcutaneous tissues, which may increase the fragility of the blood vessels, causing purpura. When a person develops bruising around the eyes or bruising after only light stoking, doctors may suspect amyloidosis. Doctors may do an examination of tissue (biopsy) taken from the fat of the abdominal wall to confirm amyloidosis. Treatment depends on how severe amyloidosis is and what other tissues are affected.


Cryoglobulinemia (see What Is Cryoglobulinemia?) occurs when abnormal immunoglobulin proteins in the blood clump together when blood cools (for example, when it flows through the arms and legs). These abnormal proteins are called cryoglobulins. When cryoglobulins clump together in blood vessels, the vessels may leak, leading to bruises and reddish sores on the skin. Cryoglobulins can be detected by laboratory testing.

Hypergammaglobulinemic purpura

In hypergammaglobulinemic purpura, blood vessels are damaged by inflammation related to high levels of immunoglobulins in the blood. This disorder primarily affects women. Recurrent crops of small, raised reddish purple discolorations develop on the lower legs. These crops leave small residual brown spots. Many people have manifestations of an underlying immune disorder such as Sjögren syndrome or systemic lupus erythematosus (lupus).

Doctors usually do blood tests. Often tests show that one type of immunoglobulin (IgG) is increased.

Hyperviscosity syndrome

Hyperviscosity syndrome occurs when people have too large a quantity of certain blood proteins (immunoglobulins). The excess immunoglobulins cause the blood to thicken and move slowly through the blood vessels. Hyperviscosity syndrome limits blood flow to the skin, fingers, toes, nose, and brain. The blood vessels become overfilled with blood and may leak, causing discoloration of the skin. Doctors may do blood tests, including one to measure the thickness of the blood.

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