(See also Overview of the Peripheral Nervous System.)
Hereditary neuropathies affect the peripheral nerves, causing subtle symptoms that worsen gradually.
Hereditary neuropathies may affect only
Motor nerves control muscle movement, and sensory nerves carry sensory information—about such things as pain, temperature, and vibration—to the brain. Autonomic nerves regulate involuntary body processes.
Some hereditary neuropathies are relatively common but often are not recognized.
The genes responsible for many hereditary neuropathies have been identified. These neuropathies include
Some forms of Charcot-Marie-Tooth disease
When the sensory nerves are affected, the ability to feel pain and changes in temperature may be impaired more than the ability to sense vibration and position (knowing where the arms and legs are). The hands and feet are affected most. Because people cannot feel pain, they may injure their feet and not know it. Such injuries increase the risk of infections, including bone infections, and risk of joint damage (called neurogenic arthropathy, or Charcot joints). If the ability to sense vibration and position is affected, people have problems with balance and walking.