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In This Topic
Brain, Spinal Cord, and Nerve Disorders
Headaches
Overview of Headache
Causes
Evaluation
Treatment
Essentials for Older People
Key Points
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Chapters in Brain, Spinal Cord, and Nerve Disorders
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  • Pain
  • Headaches
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  • Brain Dysfunction
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  • Multiple Sclerosis (MS) and Related Disorders
  • Spinal Cord Disorders
  • Peripheral Nerve Disorders
  • Cranial Nerve Disorders
  • Craniocervical Junction Disorders
  • Autonomic Nervous System Disorders
Topics in Headaches
  • Overview of Headache
  • Tension-Type Headaches
  • Migraines
  • Cluster Headaches
  • Idiopathic Intracranial Hypertension
  • Low-Pressure Headache
     
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    Overview of Headache

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    A headache is pain in any part of the head, including the scalp, upper neck, face, and interior of the head. Headaches are one of the most common reasons people visit a doctor. Headaches interfere with the ability to work and do daily tasks. Some people have frequent headaches. Other people hardly ever have them.

    Causes

    Although headaches can be painful and distressing, they are rarely due to a serious condition. Headaches can be divided into two types:

    • Primary headaches: Not caused by another disorder
    • Secondary headaches: Caused by another disorder

    Primary headache disorders include migraine, cluster headache, and tension-type headache.

    Secondary headaches may result from disorders of the brain, eyes, nose, throat, sinuses, teeth, jaws, ears, or neck or from a bodywide (systemic) disorder.

    Common causes: The two most common causes of headache are primary headaches:

    • Tension-type (most common overall)
    • Migraine

    Less common causes: Less often, headaches are due to a less common primary headache disorder called cluster headache or to one of the many secondary headache disorders (see Table 1: Headaches: Some Causes and Features of HeadachesTables). Some secondary headache disorders are serious, particularly those that involve the brain, such as meningitis, a brain tumor, or bleeding within the brain (intracerebral hemorrhage).

    Fever can cause headaches, as can many infections that do not specifically involve the brain. Such infections include Lyme disease, Rocky Mountain spotted fever, and influenza. Headaches also commonly occur when people stop consuming caffeine or stop taking pain relievers (analgesics) after using them for a long time (called medication overuse headache).

    Contrary to what most people think, eye strain and high blood pressure (except for extremely high blood pressure) do not typically cause headaches.

    Evaluation

    Warning signs: In people with headaches, certain characteristics are cause for concern:

    • Changes in sensation or vision, sudden weakness, loss of coordination, seizures, difficulty speaking or understanding speech, or changes in levels of consciousness such as drowsiness or confusion (suggesting a brain disorder)
    • A fever and a stiff neck that makes lowering the chin to the chest painful and sometimes impossible
    • A very sudden, severe headache (thunderclap headache)
    • Tenderness at the temple (as when combing hair) or jaw pain when chewing
    • The presence of cancer or a disorder that weakens the immune system (see Immunodeficiency Disorders)
    • Use of a drug that suppresses the immune system
    • Red eyes and halos seen around lights

    When to see a doctor: People who have any warning sign should see a doctor immediately. If a warning sign is present, headaches may be caused by a serious disorder. For example, a severe headache with a fever and a stiff neck suggests meningitis—a life-threatening infection of the fluid-filled space between the tissues covering the brain and spinal cord (meninges). A thunderclap headache may suggest a subarachnoid hemorrhage—bleeding within the meninges, which is often due to a ruptured aneurysm. Tenderness at the temple, particularly in older people who have lost weight and have muscle aches, may indicate giant cell arteritis. Headaches in people who have cancer or who have a weakened immune system (due to a disorder or drug) may be caused by meningitis or spread of cancer to the brain. Having red eyes and seeing halos around lights suggests glaucoma, which, if untreated, leads to irreversible loss of vision.

    People without warning signs but with certain other symptoms require prompt evaluation within a few days to a week. These symptoms include

    • Headaches that increase in frequency or severity
    • Headaches that begin after age 50
    • Worsening vision
    • Weight loss
    • A new headache that is worse when the person awakens in the morning or that awakens the person from sleep (sometimes indicating a brain tumor)

    If people with none of the above symptoms or characteristics start having headaches that are different from any they have had before or if their usual headaches become unusually severe, they should call their doctor. Depending on their other symptoms, the doctor may advise taking an analgesic or ask them to come for an evaluation.

    What the doctor does: Doctors first ask questions about the person's symptoms and medical history. Doctors then do a physical examination. What they find during the history and physical examination often suggests a cause of the pain and tests that may need to be done (see Table 1: Headaches: Some Causes and Features of HeadachesTables).

    Doctors ask about the characteristics of the headache: how often it occurs, how long it lasts, where the pain is, how severe is it, whether any symptoms accompany it, and how long a sudden headache takes to reach its maximum intensity. Doctors also ask what triggers the headache, what makes it worse, and what relieves it.

    Risk factors for headache are identified. They include whether people take or have stopped taking certain drugs, whether they have had a spinal tap recently, and whether they have a disorder that may account for the headache. A general physical examination is done. It focuses on the head and neck and on the brain, spinal cord, and nerves (neurologic examination—see Symptoms and Diagnosis of Brain, Spinal Cord, and Nerve Disorders: Physical Examination).

    A free website at http://promyhealth.org provides a questionnaire that can help people with headaches communicate with their doctor. The questionnaire asks many of the questions that headache specialists use to help diagnose the cause of headaches. People can fill out the questionnaire, print the results, and take them to their doctor. This approach can save the people and their doctor time and help guide the evaluation.

    Testing: Most people do not need testing. However, if doctors suspect a serious disorder, tests are usually done. For some suspected disorders, tests are done as soon as possible. In other cases, testing can be done within one or more days.

    Magnetic resonance imaging (MRI) or computed tomography (CT) is done immediately if people have

    • A thunderclap headache
    • Changes in levels of consciousness, such as drowsiness or confusion
    • Swelling of the optic nerve, detected by eye examination with an ophthalmoscope
    • Symptoms that suggest a brain disorder, such as changes in sensation or vision, sudden weakness, loss of coordination, seizures, or difficulty speaking or understanding speech
    • Extremely high blood pressure

    MRI (usually) or CT is done within a day or so if people have cancer or a weakened immune system (due to a disorder or a drug). MRI or CT is done within a few days if people have certain other characteristics—for example, headaches that begin after age 50, weight loss, double vision, a new headache that is worse when the person awakens in the morning or that awakens the person from sleep, and sometimes an increase in the frequency, duration, or intensity of chronic headaches.

    A spinal tap (lumbar puncture—see Symptoms and Diagnosis of Brain, Spinal Cord, and Nerve Disorders: Spinal Tap) is done immediately if acute meningitis or encephalitis (a brain infection) is suspected. Sometimes doctors do CT or MRI before the spinal tap if they think that a mass (such as a tumor, an abscess, or a hematoma) may be present. A spinal tap can be dangerous if people have such a mass. Doctors also do a spinal tap if people have a thunderclap headache (suggesting subarachnoid hemorrhage) and the results of CT or MRI are normal.

    Other tests are done within hours or days, depending on the examination results and the causes that are suspected (see Table 1: Headaches: Some Causes and Features of HeadachesTables).

    PrintOpen table in new window Open table in new window
    Some Causes and Features of Headaches

    Type or Cause

    Common Features*

    Tests

    Primary headache (not due to another disorder)

    Cluster

    A severe, piercing headache that

    • Affects one side of the head and is focused around the eye
    • Lasts 30 to 180 minutes
    • Occurs at the same time of day
    • Occurs in clusters, separated by periods of time when no headaches occur
    • Is usually not worsened by light, sounds, or odors
    • Is not accompanied by vomiting

    Inability to lie down and restlessness (sometimes expressed by pacing)

    On the same side as the pain: A runny nose, tearing, drooping of the eyelid, and sometimes swelling of the area below the eye

    Occasionally CT or MRI of the head to rule out other disorders, particularly if the headaches have developed recently or if the pattern of symptoms has changed

    Migraine

    A moderate to severe headache that

    • Is typically pulsating or throbbing, usually on one side but sometimes on both sides of the head
    • Lasts several hours to days
    • Can occur frequently for a long time, then disappear for weeks, months, or years
    • May be triggered by exertion, lack of sleep, a head injury, hunger, or certain wines and foods
    • Is lessened with sleep
    • May be accompanied by nausea, vomiting, and sensitivity to loud sounds, bright light, and/or odors

    Often a sensation that a migraine is beginning (called a prodrome), which may include mood changes, loss of appetite, and nausea

    Sometimes preceded by temporary disturbances in sensation, balance, muscle coordination, speech, or vision, such as seeing flashing lights and having blind spots (these symptoms are called the aura)

    Same as those for cluster headaches

    Tension-type

    Usually a mild to moderate headache that

    • Feels like tightening of a band around the head
    • Affects the whole head
    • Lasts 30 minutes to several days
    • May be worse at the end of the day
    • Is not worsened by physical activity, light, sounds, or odors
    • Is not accompanied by nausea, vomiting, or any other symptoms

    Same as those for cluster headaches

    Secondary headache (due to another disorder)

    Altitude illness

    Light-headedness, loss of appetite, nausea and vomiting, fatigue, weakness, irritability, or difficulty sleeping

    In people who have recently gone to a high altitude (including flying 6 hours or more in an airplane)

    A doctor's examination

    Brain tumor, abscess, or another mass in the brain, such as a hematoma (an accumulation of blood)

    A mild to severe headache that

    • May become progressively worse
    • Worsens when a person lies down and may awaken a person from sleep
    • Usually recurs more and more often and eventually becomes constant without relief
    • May result in blurred vision when a person suddenly changes position
    • May be accompanied by clumsiness, weakness, confusion, nausea, vomiting, seizures, or impaired vision

    MRI or CT

    Carbon monoxide exposure (during winter, people may breathe this gas if heating equipment is not adequately vented)

    Possibly no awareness of the exposure because carbon monoxide is colorless and odorless

    A blood test

    Dental infections (in upper teeth)

    Pain that is

    • Usually felt over the face and mostly on one side
    • Worse when chewing

    Toothache

    Dental examination

    Encephalitis (infection of the brain)

    Headaches with varying characteristics

    Often accompanied by fever, worsening drowsiness, confusion, agitation, weakness, and/or clumsiness

    Seizures and coma

    MRI or CT and a spinal tap

    Giant cell (temporal) arteritis

    A throbbing pain felt on one side of the head at the temple

    Pain when combing the hair or while chewing

    Sometimes enlarged arteries in the temples (temporal arteries) and aches and pains, particularly in the shoulders, thighs, and hips

    Possibly impaired vision or loss of vision

    More common among people over 60

    A blood test to measure the erythrocyte sedimentation rate (ESR), which can detect inflammation

    Biopsy of the temporal artery

    Glaucoma—a type called closed-angle glaucoma—that starts abruptly (acute)

    Moderate or severe pain that

    • Occurs at the front of the head or in or over an eye
    • May begin when the person is in a dark room

    Red eyes, halos seen around lights, nausea, and loss of vision

    An eye examination as soon as possible

    Head injury (postconcussion syndrome)

    Headache that begins immediately or shortly after a head injury (with or without loss of consciousness)

    Sometimes a faulty memory, personality changes, or both

    CT or MRI with normal results

    Idiopathic intracranial hypertension (increased pressure within the skull without any evidence of a cause)

    Headaches that

    • Occur daily or almost daily, with fluctuating intensity
    • Affect both sides of the head

    Sometimes nausea or ringing in the ears that occurs in time with the pulse

    MRI and magnetic resonance venography, followed by a spinal tap

    Intracerebral hemorrhage

    Mild or severe pain that

    • Begins suddenly
    • Occurs on one or both sides of the head
    • Is accompanied often by nausea and sometimes by vomiting

    Possibly severe drowsiness, clumsiness, weakness, difficulty speaking or understanding speech, loss of vision, loss of sensation, or confusion

    Occasionally seizures or coma

    CT or MRI

    Medication overuse headache

    Chronic and often daily headaches

    Often in people who have migraine or tension-type headaches

    Overuse of pain relievers (analgesics such as NSAIDs or opioids), barbiturates, caffeine, or sometimes triptans or other drugs to treat headaches

    A doctor's examination

    Meningitis

    A severe, constant headache

    Fever

    Neck stiffness that makes lowering the chin to the chest painful and sometimes impossible

    A feeling of illness, drowsiness, nausea, or vomiting

    A spinal tap (often preceded by CT)

    Obstructive sleep apnea

    Headaches that occur in the morning

    Snoring with episodes of gasping or choking, typically after pauses in breathing during sleep

    Daytime sleepiness

    A doctor's examination

    Sleep laboratory evaluation with polysomnography

    Sinusitis

    Pain that

    • Is sometimes felt in the face, at the front of the head, or as tooth pain
    • May begin suddenly and last only days or hours or begin gradually and be persistent
    • Is worse when facing the floor

    A runny nose, sometimes with pus or blood

    A feeling of illness, possibly a cough at night, and often a fever

    Possibly CT of the sinuses or endoscopy of the nose

    Subarachnoid hemorrhage (bleeding between the inner and middle layers of tissues covering the brain)

    Severe, constant pain that

    • Begins suddenly and peaks within a few seconds (thunderclap headache)
    • Is often described as the worst headache ever experienced

    Possibly brief loss of consciousness as the headache begins

    Possibly drowsiness, confusion, difficulty being aroused, or coma

    A stiff neck, nausea and vomiting, dizziness, and low back pain

    MRI or CT

    If MRI or CT results are negative or inconclusive, a spinal tap

    Subdural hematoma (a pocket of blood between the outer and middle layers of tissues covering the brain)

    Headaches with varying characteristics

    Possibly sleepiness, confusion, forgetfulness, and/or weakness or paralysis on one side of the body

    MRI or CT

    Temporomandibular disorders

    Pain when chewing hard foods

    Sometimes pain in or around the jaw or in the neck

    Sometimes clicking or popping when the mouth is opened, locking of the jaw, or difficulty opening the mouth wide

    Physical examination

    Occasionally MRI, x-rays, or CT

    *Features include symptoms and results of the doctor's examination. Features mentioned are typical but not always present.

    CT = computed tomography; MRI = magnetic resonance imaging; NSAIDs = nonsteroidal anti-inflammatory drugs.

    Some Causes and Features of Headaches

    Type or Cause

    Common Features*

    Tests

    Primary headache (not due to another disorder)

    Cluster

    A severe, piercing headache that

    • Affects one side of the head and is focused around the eye
    • Lasts 30 to 180 minutes
    • Occurs at the same time of day
    • Occurs in clusters, separated by periods of time when no headaches occur
    • Is usually not worsened by light, sounds, or odors
    • Is not accompanied by vomiting

    Inability to lie down and restlessness (sometimes expressed by pacing)

    On the same side as the pain: A runny nose, tearing, drooping of the eyelid, and sometimes swelling of the area below the eye

    Occasionally CT or MRI of the head to rule out other disorders, particularly if the headaches have developed recently or if the pattern of symptoms has changed

    Migraine

    A moderate to severe headache that

    • Is typically pulsating or throbbing, usually on one side but sometimes on both sides of the head
    • Lasts several hours to days
    • Can occur frequently for a long time, then disappear for weeks, months, or years
    • May be triggered by exertion, lack of sleep, a head injury, hunger, or certain wines and foods
    • Is lessened with sleep
    • May be accompanied by nausea, vomiting, and sensitivity to loud sounds, bright light, and/or odors

    Often a sensation that a migraine is beginning (called a prodrome), which may include mood changes, loss of appetite, and nausea

    Sometimes preceded by temporary disturbances in sensation, balance, muscle coordination, speech, or vision, such as seeing flashing lights and having blind spots (these symptoms are called the aura)

    Same as those for cluster headaches

    Tension-type

    Usually a mild to moderate headache that

    • Feels like tightening of a band around the head
    • Affects the whole head
    • Lasts 30 minutes to several days
    • May be worse at the end of the day
    • Is not worsened by physical activity, light, sounds, or odors
    • Is not accompanied by nausea, vomiting, or any other symptoms

    Same as those for cluster headaches

    Secondary headache (due to another disorder)

    Altitude illness

    Light-headedness, loss of appetite, nausea and vomiting, fatigue, weakness, irritability, or difficulty sleeping

    In people who have recently gone to a high altitude (including flying 6 hours or more in an airplane)

    A doctor's examination

    Brain tumor, abscess, or another mass in the brain, such as a hematoma (an accumulation of blood)

    A mild to severe headache that

    • May become progressively worse
    • Worsens when a person lies down and may awaken a person from sleep
    • Usually recurs more and more often and eventually becomes constant without relief
    • May result in blurred vision when a person suddenly changes position
    • May be accompanied by clumsiness, weakness, confusion, nausea, vomiting, seizures, or impaired vision

    MRI or CT

    Carbon monoxide exposure (during winter, people may breathe this gas if heating equipment is not adequately vented)

    Possibly no awareness of the exposure because carbon monoxide is colorless and odorless

    A blood test

    Dental infections (in upper teeth)

    Pain that is

    • Usually felt over the face and mostly on one side
    • Worse when chewing

    Toothache

    Dental examination

    Encephalitis (infection of the brain)

    Headaches with varying characteristics

    Often accompanied by fever, worsening drowsiness, confusion, agitation, weakness, and/or clumsiness

    Seizures and coma

    MRI or CT and a spinal tap

    Giant cell (temporal) arteritis

    A throbbing pain felt on one side of the head at the temple

    Pain when combing the hair or while chewing

    Sometimes enlarged arteries in the temples (temporal arteries) and aches and pains, particularly in the shoulders, thighs, and hips

    Possibly impaired vision or loss of vision

    More common among people over 60

    A blood test to measure the erythrocyte sedimentation rate (ESR), which can detect inflammation

    Biopsy of the temporal artery

    Glaucoma—a type called closed-angle glaucoma—that starts abruptly (acute)

    Moderate or severe pain that

    • Occurs at the front of the head or in or over an eye
    • May begin when the person is in a dark room

    Red eyes, halos seen around lights, nausea, and loss of vision

    An eye examination as soon as possible

    Head injury (postconcussion syndrome)

    Headache that begins immediately or shortly after a head injury (with or without loss of consciousness)

    Sometimes a faulty memory, personality changes, or both

    CT or MRI with normal results

    Idiopathic intracranial hypertension (increased pressure within the skull without any evidence of a cause)

    Headaches that

    • Occur daily or almost daily, with fluctuating intensity
    • Affect both sides of the head

    Sometimes nausea or ringing in the ears that occurs in time with the pulse

    MRI and magnetic resonance venography, followed by a spinal tap

    Intracerebral hemorrhage

    Mild or severe pain that

    • Begins suddenly
    • Occurs on one or both sides of the head
    • Is accompanied often by nausea and sometimes by vomiting

    Possibly severe drowsiness, clumsiness, weakness, difficulty speaking or understanding speech, loss of vision, loss of sensation, or confusion

    Occasionally seizures or coma

    CT or MRI

    Medication overuse headache

    Chronic and often daily headaches

    Often in people who have migraine or tension-type headaches

    Overuse of pain relievers (analgesics such as NSAIDs or opioids), barbiturates, caffeine, or sometimes triptans or other drugs to treat headaches

    A doctor's examination

    Meningitis

    A severe, constant headache

    Fever

    Neck stiffness that makes lowering the chin to the chest painful and sometimes impossible

    A feeling of illness, drowsiness, nausea, or vomiting

    A spinal tap (often preceded by CT)

    Obstructive sleep apnea

    Headaches that occur in the morning

    Snoring with episodes of gasping or choking, typically after pauses in breathing during sleep

    Daytime sleepiness

    A doctor's examination

    Sleep laboratory evaluation with polysomnography

    Sinusitis

    Pain that

    • Is sometimes felt in the face, at the front of the head, or as tooth pain
    • May begin suddenly and last only days or hours or begin gradually and be persistent
    • Is worse when facing the floor

    A runny nose, sometimes with pus or blood

    A feeling of illness, possibly a cough at night, and often a fever

    Possibly CT of the sinuses or endoscopy of the nose

    Subarachnoid hemorrhage (bleeding between the inner and middle layers of tissues covering the brain)

    Severe, constant pain that

    • Begins suddenly and peaks within a few seconds (thunderclap headache)
    • Is often described as the worst headache ever experienced

    Possibly brief loss of consciousness as the headache begins

    Possibly drowsiness, confusion, difficulty being aroused, or coma

    A stiff neck, nausea and vomiting, dizziness, and low back pain

    MRI or CT

    If MRI or CT results are negative or inconclusive, a spinal tap

    Subdural hematoma (a pocket of blood between the outer and middle layers of tissues covering the brain)

    Headaches with varying characteristics

    Possibly sleepiness, confusion, forgetfulness, and/or weakness or paralysis on one side of the body

    MRI or CT

    Temporomandibular disorders

    Pain when chewing hard foods

    Sometimes pain in or around the jaw or in the neck

    Sometimes clicking or popping when the mouth is opened, locking of the jaw, or difficulty opening the mouth wide

    Physical examination

    Occasionally MRI, x-rays, or CT

    *Features include symptoms and results of the doctor's examination. Features mentioned are typical but not always present.

    CT = computed tomography; MRI = magnetic resonance imaging; NSAIDs = nonsteroidal anti-inflammatory drugs.

    Treatment

    Treatment depends on the cause. If the headache is a tension headache or if it accompanies a minor viral infection, people can take acetaminophenSome Trade Names
    TYLENOL
    or a nonsteroidal anti-inflammatory drug (NSAID—see Pain: Nonsteroidal Anti-Inflammatory Drugs).

    Essentials for Older People

    If headaches begin after age 50, doctors usually assume they result from another disorder until proved otherwise. Disorders that cause headaches, such as giant cell arteritis, brain tumors, and subdural hematomas (which may result from falls), are more common among older people.  

    Treatment of headaches may be limited in older people. They are more likely to have disorders that prevent them from taking some of the drugs used to treat migraines and cluster headaches (triptans and dihydroergotamineSome Trade Names
    D.H.E. 45 MIGRANAL
    —see Headaches: Drugs Used to Treat MigrainesTables). These disorders include angina, coronary artery disease, and uncontrolled high blood pressure. If older people need to take drugs to treat headaches that can have sedating effects, they must be monitored closely.

    Key Points

    • Most headaches do not have a serious cause, particularly if the headaches began at a young age, if they have not changed over time, and if results of the examination are normal.  
    • If warning signs (see Headaches: Warning signs) are present, people should see a doctor.  
    • Most headaches do not require testing. 
    • Doctors can usually determine the type or cause of headaches based on the medical history, symptoms, and results of a physical examination.
    • If doctors suspect that the cause is a serious disorder (such as a hemorrhage or an infection), CT or MRI is done, often immediately.  
    • If doctors suspect meningitis or encephalitis, a spinal tap is done.

    Last full review/revision May 2012 by Stephen D. Silberstein, MD

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    Pronunciations

    acetaminophen

    aneurysm

    angina

    apnea

    arteritis

    barbiturates

    computed tomography

    encephalitis

    endoscopy

    ergotamine

    hematoma

    hemorrhage

    idiopathic

    intracerebral

    meninges

    meningitis

    neurologic

    opioids

    polysomnography

    subarachnoid

    subarachnoid hemorrhage

    subdural

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