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Insomnia

Insomnia is difficulty falling asleep or staying asleep or a disturbance in sleep quality that makes sleep seem inadequate or unrefreshing.

  • People are sleepy and tired during the day and have trouble functioning.
  • Doctors base the diagnosis on a detailed description of sleep habits and patterns and sometimes use testing in a sleep laboratory.
  • If possible, the cause is corrected, sometimes with changes in lifestyle, but sleep aids may be needed.

Insomnia is usually a symptom that can have many different causes:

  • An irregular sleep-wake schedule
  • Poor sleep habits (for example, drinking a caffeinated beverage in the afternoon or evening or exercising late at night)
  • Physical disorders (such as those that cause pain or make people urinate more often)
  • Use or withdrawal of a drug
  • Drinking large amounts of alcohol in the evening
  • Emotional problems, anxiety, and stress

However, insomnia itself can be a disorder on its own. Some people have long-standing (chronic) insomnia that has little or no apparent relationship to any particular cause.

Difficulty falling and staying asleep and waking up earlier than desired are common among young and old. About 10% of adults have chronic insomnia, and about 50% have insomnia sometimes.

Because sleep patterns deteriorate as people age, older people are more likely to report insomnia than younger people. As people age, they tend to sleep less at night and to feel sleepier and to nap during the day. Stages 3 and 4 sleep, the periods of deep sleep that is most refreshing, become shorter and eventually disappear. Also, older people awaken more during all stages of sleep. Usually, these changes alone do not indicate a sleep disorder in the elderly.

There are several types of insomnia:

  • Difficulty falling asleep (sleep-onset insomnia): Commonly, people have difficulty falling asleep when they cannot let their minds relax and they continue to think and worry. Sometimes the body is not ready for sleep at what is considered a usual time for sleep. That is, the body's internal clock is out of sync with the earth's cycle of light and dark. This problem (a type of circadian rhythm sleep disorder) is common among adolescents and young adults.
  • Difficulty staying asleep (sleep maintenance insomnia): Older people are more likely to have difficulty staying asleep than are younger people. People with this type of insomnia fall asleep normally but wake up several hours later and cannot fall asleep again easily. Sometimes they drift in and out of a restless, unsatisfactory sleep.
  • Early morning awakening: This type may be a sign of depression in people of any age.

Symptoms and Diagnosis

Symptoms include irritability, fatigue during the day, and problems concentrating or performing under stress.

To diagnose insomnia, doctors ask people about their sleep patterns, habits around bedtime, use of drugs (including illicit drugs), use of other substances (such as alcohol, caffeine, and tobacco), degree of psychologic stress, medical history, and level of physical activity. People may be asked to keep a sleep log. In it, they record a detailed description of the sleep habits, including sleep and wake times, use of naps, and any problems with sleeping.

Some people need less sleep than others, so the diagnosis of insomnia is based on individual needs.

A physical examination is done to check for disorders that can cause insomnia. Occasionally, if insomnia persists despite measures to correct it, people may be referred to a sleep disorders specialist for evaluation and sometimes tests such as polysomnography. For this test, brain activity, heart rate, breathing, muscle activity, and eye movements are monitored while people sleep.

Treatment

The treatment of insomnia depends on its cause and severity. If insomnia results from another disorder, treatment of that disorder may improve sleep. For most people who have insomnia, some simple changes in lifestyle, such as following a regular sleep schedule and avoiding caffeine after lunch time, can improve sleep.

When a sleep disorder interferes with normal activities and a sense of well-being, taking sleep aids (also called hypnotics) occasionally for up to a few weeks may help. Most sleep aids require a prescription. Some are available without a prescription (over-the-counter, or OTC), but an OTC sleep aid may be no safer than a prescription sleep aid, especially for older people. OTC sleep aids contain diphenhydramineSome Trade Names
BENADRYL
or doxylamineSome Trade Names
UNISOM
, both antihistamines, which may have side effects, such as drowsiness or sometimes nervousness, agitation, falls, and confusion, especially in older people (see Over-the-Counter Drugs). OTC sleep aids should not be taken for more than 7 to 10 days. They are intended to manage an occasional sleepless night, not chronic insomnia, which could signal a serious underlying problem.

For people with insomnia related to a “stressed mind,” the most effective and safest treatment is usually talk therapy, done by trained specialists. This approach helps people understand the problem, unlearn bad sleeping habits, and eliminate unhelpful thoughts, such as worry about losing sleep or the next day's activities. Older people who have interrupted sleep can benefit from regular bedtimes, lots of environmental light exposure during the day, regular exercise, and less napping during the day because napping may make getting a good night's sleep even harder. Many older people with insomnia do not need to take sleep aids. But if they do, they should keep in mind that these drugs can cause problems. Thus, caution is required.

People who have insomnia and depression should be evaluated by a doctor, and the depression should be treated. Treating depression often relieves the insomnia, but some antidepressants can improve sleep directly because they have sedating effects. Usually, the antidepressant relieves depression but does not improve sleep. Then doctors may prescribe a sleep aid in addition.

Melatonin (see Medicinal Herbs and Nutraceuticals: Melatonin) is sometimes used to treat insomnia, especially in older people, who may have a low levels of melatonin. However, its use is controversial. Melatonin appears to be safe for short-term use (up to a few weeks), but the effects of using it for a long time are unknown. Many other medicinal herbs and dietary supplements, such as skullcap and valerian, are available in health food stores, but their effects on sleep and side effects are not well understood.

Ways to Improve Sleep
  • Follow a regular sleep schedule: People should go to bed at the same time each night and, more importantly, get up at the same time each morning, even on weekends and vacations.
  • Follow a bedtime routine: A regular pattern of activities—such as walking at a relaxed pace, listening to soft music, brushing the teeth, washing the face, and setting the alarm clock—can set the mood for sleep. This routine should be followed every night, at home or away.
  • Make the environment conducive to sleep: The bedroom should be kept dark, quiet, and not too warm or too cold. Loud noises can disturb sleep even when people are not awakened by them. Wearing ear plugs, using a white-noise machine or a fan, or installing heavy curtains in the bedroom (to block out outside noises) can help.
  • Use the bedroom primarily for sleeping: The bedroom should not be used for eating, reading, watching television, paying bills, or other activities associated with wakefulness (other than intimate activity).
  • Avoid substances that interfere with sleep: Food and beverages that contain alcohol or caffeine (such as coffee, tea, cola drinks, and chocolate) can interfere with sleep, as can appetite suppressants, diuretics, and nicotine (in cigarettes and nicotine patches). Caffeinated substances should not be consumed within 12 hours of bedtime. Drinking a large amount of alcohol in the evening causes early morning awakenings. Quitting smoking may help.
  • Use pillows: Pillows between the knees or under the waist can make people more comfortable. For people with back problems, lying on the side with a large pillow between the knees may help.
  • Get up: When falling asleep is difficult, getting up and doing something else in another room and coming back to bed when sleepy may be more effective than lying in bed and trying harder and harder to fall asleep.
  • Exercise regularly: Exercise can help people fall asleep naturally. However, exercise within 5 hours of bedtime can stimulate the heart and brain and keep people awake.
  • Relax: Stress and worry are major impediments to sleep. People who are not sleepy at bedtime can relax by reading or taking a warm bath. People can aim to leave their problems at the bedroom door. Avoiding too much mental stimulation during the hour or so before bedtime can help. Scheduling a “worry time” during the day to think about concerns can diminish the need to worry at bedtime.
  • Eat a light snack: Hunger can interfere with going to sleep. A light snack, especially if warm, can help, unless a person has gastroesophageal reflux (GERD). However, heavy meals near bedtime should be avoided. They may cause heartburn, which can interfere with sleep.
  • Eliminate behavior that provokes anxiety: Turn the clock away so that time is not a focus.

Sleep Aids: Not to Be Taken Lightly

Among the most commonly used sleep aids are sedatives, minor tranquilizers, and antianxiety drugs. Most are safe as long as a doctor supervises their use.

Most sleep aids require a doctor's prescription because they may cause problems. Many of these problems are less common with newer sleep aids.

  • Loss of effectiveness: Once people become accustomed to a sleep aid, it may become ineffective. This effect is called tolerance.
  • Withdrawal symptoms: If a sleep aid is taken for more than a few days, stopping it can make the original sleep problem suddenly worse (causing rebound insomnia) and can increase anxiety. Thus, doctors recommend reducing the dose slowly over a period of several weeks until the drug is stopped.
  • Habit-forming or addiction potential: People who use sleep aids for more than a few days may feel that they cannot sleep without them. Stopping the drug makes them anxious, nervous, and irritable or causes disturbing dreams.
  • Potential for overdose: If taken in higher than recommended doses, some of the older sleep aids can cause confusion, delirium, dangerously slow breathing, a weak pulse, blue fingernails and lips, and even death.
  • Serious side effects: Most sleep aids, even when taken at recommended doses, are particularly risky for older people and for people with breathing problems because they tend to suppress areas of the brain that control breathing. Some can reduce daytime alertness, making driving or operating machinery hazardous. Sleep aids are especially dangerous when taken with alcohol, opioids (narcotics), antihistamines, or antidepressants because these drugs also cause daytime drowsiness and can suppress breathing. The combined effects are more dangerous. Rarely, especially if taken at higher than recommended doses or with alcohol, sleep aids have been known to cause people to walk or even drive during sleep and to cause severe allergic reactions.

Newer sleep aids can be used for longer periods of time without losing effect, becoming habit-forming, or causing withdrawal. They are also less dangerous in an overdose.

Benzodiazepines are the most commonly used sleep aids. Some benzodiazepines (such as chlordiazepoxideSome Trade Names
LIBRIUM
, diazepamSome Trade Names
DIASTAT VALIUM
, flurazepamSome Trade Names
DALMANE
, and nitrazepam) are longer acting than others (such as temazepamSome Trade Names
RESTORIL
and triazolamSome Trade Names
HALCION
). Doctors try to avoid prescribing long-acting benzodiazepines for older people. Older people cannot metabolize and excrete drugs as well as younger people. Thus for them, taking these drugs may be more likely to cause daytime drowsiness, slurred speech, and falls.

Other useful sleep aids are not benzodiazepines, but work at the same brain areas as the benzodiazepines. These drugs (eszopicloneSome Trade Names
LUNESTA
, zolpidemSome Trade Names
AMBIEN
, and zaleplonSome Trade Names
SONATA
) are shorter acting than most of benzodiazepines and are less likely to lead to daytime drowsiness. Older people appear to tolerate these drugs well. There is also a longer-acting (extended-release, or ER) version of zolpidemSome Trade Names
AMBIEN
. RamelteonSome Trade Names
ROZEREM
, a newer sleep aid, has the same advantages as these shorter-acting drugs. In addition, it can be used longer than benzodiazepines without losing its effectiveness or causing withdrawal symptoms. It is not habit-forming and does not appear to have overdose potential. RamelteonSome Trade Names
ROZEREM
affects the same area of the brain as melatonin (a hormone that helps promote sleep) and is thus called a melatonin receptor agonist.

Some antidepressants (most commonly trazodone) can relieve insomnia and prevent early morning awakening, but side effects, such as daytime sleepiness, can be a problem, especially for older people. Low doses are used to treat insomnia unless it is caused by depression. Then, higher doses, usually used to treat depression, are used.

Diphenhydramine and dimenhydrinate are two inexpensive over-the-counter antihistamines that can relieve occasional or mild sleeping problems. However, they are not the best sleep aids, and they may have side effects, including daytime sleepiness, confusion, and urinary difficulties, especially in older people.

Last full review/revision March 2008 by Karl Doghramji, MD

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