Neuroblastoma is a common childhood cancer that grows in parts of the nervous system.
A neuroblastoma develops in a certain kind of nerve tissue located in many places of the body. It usually originates in nerves in the abdomen or chest, most commonly in the adrenal glands (located above each kidney). Very rarely, a neuroblastoma originates in the brain. In over half of the children, the cancer has spread to other parts of the body by the time a doctor is consulted.
Neuroblastoma is the most common cancer among infants and one of the most common tumors among children of any age. About 90% of all neuroblastomas occur in children younger than 5 years. The cause is not known. Rarely, neuroblastomas run in families.
The symptoms depend on where the neuroblastoma originated and whether and where it has spread, as in the following:
About 90 to 95% of neuroblastomas produce hormones, such as epinephrine, which sometimes increase the heart rate and cause anxiety.
Early diagnosis of a neuroblastoma is not easy. If the cancer has grown large enough, a doctor may be able to feel a lump in the abdomen. A doctor who suspects a neuroblastoma may suggest ultrasonography, computed tomography (CT), or magnetic resonance imaging (MRI) of the chest and abdomen. A urine sample can be tested for excessive production of epinephrine-like hormones.
To see whether the cancer has spread, the doctor may do a bone scan, take x-rays of bones, or examine tissue samples from the liver, lungs, skin, bone marrow, or bone.
Prognosis and Treatment
Children younger than 1 year and children with small cancers have a very good prognosis. In children older than 1 year, the cure rate is low if the cancer has spread.
If the cancer has not spread, it can usually be removed by surgery. Most children are given chemotherapy drugs such as vincristine, cyclophosphamide, doxorubicin, etoposide, and cisplatin. Also, radiation therapy may be used in addition to surgery when chemotherapy is ineffective or when tumors are inoperable.
Last full review/revision January 2009 by David N. Korones, MD