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Gastroenteritis is inflammation of the lining of the stomach and small and large intestines. It is usually caused by infection with a microorganism but can also be caused by ingestion of chemical toxins or drugs.
Gastroenteritis usually consists of mild to severe diarrhea that may be accompanied by loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen. Although gastroenteritis usually is not serious in a healthy adult, causing only discomfort and inconvenience, it can cause life-threatening dehydration (see Water Balance: Dehydration) and electrolyte imbalance (see Electrolyte Balance) in the very ill or weak, the very young, and the very old. Each year in the United States, about 1 in 6 people develops gastroenteritis by eating contaminated food. About 1.5 million children around the world die each year from infectious gastroenteritis.
Causes
Infections that cause gastroenteritis can be transmitted from person to person, especially if people with diarrhea do not thoroughly wash their hands after a bowel movement. Infection also can occur if people touch their mouth after touching an object (such as a diaper or toy) contaminated by infected stool. All such transmission involving infected stool is termed fecal-oral transmission. A person, and sometimes large numbers of people (in which case an outbreak of illness is called an epidemic), can also become infected by eating food or drinking water that has been contaminated by infected stool. Most foods can be contaminated with bacteria and cause gastroenteritis if not cooked thoroughly or pasteurized. Contaminated water is sometimes ingested in unexpected ways, such as when swimming in a pond contaminated by stool from an animal or in a swimming pool contaminated by stool from another person. In some cases, gastroenteritis is acquired through contact with animals that carry the infectious microorganism.
Infectious gastroenteritis may be caused by viruses, bacteria, or parasites. Chemical toxins and drugs can also cause gastroenteritis.
Viruses:
Viruses are the most common cause of gastroenteritis in the United States. Certain viruses infect cells in the lining of the small intestine where they multiply and cause watery diarrhea, vomiting, and fever. Four categories of viruses cause most gastroenteritis: rotavirus, calicivirus (predominantly the norovirus), and less commonly, astrovirus, and enteric (intestinal) adenovirus.
Rotavirus (see Viral Infections in Infants and Children) is the most common cause of severe, dehydrating diarrhea among young children. It usually affects those between the ages of 3 months and 15 months. Rotavirus is highly contagious. Most infections are spread by fecal-oral transmission. Adults may be infected after close contact with an infected infant, but the illness is generally mild. During the winter in temperate climates, rotavirus causes most cases of diarrhea that are serious enough to send infants and toddlers to the hospital. Each year in the United States, a wave of rotavirus illness begins in the Southwest in November and ends in the Northeast in March.
Norovirus most commonly infects older children and adults. Infections occur year-round, but 80% occur from November to April. Most people are infected after swallowing contaminated food or water. Because norovirus is highly contagious, infection can easily be spread from person to person.
Astrovirus can infect people of all ages but usually infects infants and young children. Infection is most common in the winter and is spread by fecal-oral transmission.
Adenovirus most commonly affects children under the age of 2. Infections occur year-round and increase slightly in the summer. The infection is spread by fecal-oral transmission.
Other viruses (such as cytomegalovirus and enterovirus) can cause gastroenteritis in people who have an impaired immune system.
Bacteria:
Bacterial gastroenteritis is less common than viral gastroenteritis. Bacteria cause gastroenteritis by various means. Certain species, such as Vibrio cholerae, and enterotoxigenic strains of Escherichia coli (E. coli) and Clostridium difficile attach to the lining of the intestines without invading and produce enterotoxins. These toxins cause the intestines to secrete water and minerals, resulting in watery diarrhea.
Some bacteria (such as certain strains of E. coli, Campylobacter, Shigella, and Salmonella) invade the lining of the small intestine or colon. There, they damage cells, causing tiny sores (ulcerations) that bleed, and allow a considerable leakage of fluid containing proteins, electrolytes, and water. The diarrhea contains white and red blood cells and sometimes visible blood.
Salmonella and Campylobacter are the most common bacterial causes of diarrhea in the United States. Both infections are most frequently acquired from undercooked poultry. Unpasteurized milk is also a possible source. Campylobacter is occasionally transmitted by dogs or cats with diarrhea. Salmonella can be transmitted by undercooked eggs and by having contact with reptiles (such as turtles or lizards), birds, or amphibians (such as frogs and salamanders).
Species of Shigella are the third most common bacterial cause of diarrhea in the United States and are usually transmitted person to person (especially in day care centers), although foodborne outbreaks occur.
Several different subtypes of E. coli cause diarrhea. Enterohemorrhagic E. coli (also called Shiga toxin-producing E. coli) is the most significant subtype of E. coli in the United States and causes hemorrhagic colitis (see Gastroenteritis: Hemorrhagic Colitis) and sometimes hemolytic-uremic syndrome (see Platelet Disorders: Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS)). The strain E. coli O157:H7 is the most common strain of this subtype in the United States. Undercooked ground beef, unpasteurized milk and juice, and contaminated water are possible sources. Person-to-person transmission is common in day care centers. Outbreaks have occurred among people who have gone swimming in pools, lakes, or oceans or at water parks (called recreational water illness―see What Are Recreational Water Illnesses (RWIs)?). Another subtype of E. coli (called enterotoxigenic E. coli) produces two toxins that cause watery diarrhea. This subtype is the most common cause of traveler's diarrhea (see Gastroenteritis: Traveler's Diarrhea) in people visiting developing countries. A third subtype of E. coli also causes watery diarrhea. It was once a common cause of diarrhea outbreaks in nurseries but is now rare. A fourth subtype of E. coli causes bloody or nonbloody diarrhea, primarily in developing countries. It is rare in the United States.
Other bacteria (such as Staphylococcus aureus, Bacillus cereus, and Clostridium perfringens) produce a toxin that can be present in contaminated food. The toxin can cause gastroenteritis without causing a bacterial infection. These toxins generally cause severe nausea, vomiting, and diarrhea. Symptoms begin within 12 hours of ingestion of contaminated food and lessen within 36 hours.
Several other bacteria cause gastroenteritis, but most are rare in the United States. Yersinia enterocolitica can cause gastroenteritis or a syndrome that mimics appendicitis. A person is infected after ingesting undercooked pork, unpasteurized milk, or contaminated water. Several Vibrio species (such as Vibrio parahaemolyticus) cause diarrhea after ingestion of undercooked seafood. Vibrio cholerae, which is responsible for the watery diarrhea that is the main symptom of cholera, sometimes causes severe dehydrating diarrhea in developing countries. Epidemics may occur after natural disasters or in refugee camps. Listeria causes foodborne gastroenteritis. Aeromonas is acquired from swimming in or drinking contaminated fresh water or briny, salty water. Plesiomonas shigelloides can cause diarrhea in people who have eaten raw shellfish or traveled to tropical regions in developing countries.
Parasites:
Certain intestinal parasites, particularly Giardia intestinalis, stick to or invade the lining of the intestine and cause nausea, vomiting, diarrhea, and a general sick feeling. The resulting infection, called giardiasis, is more common in cold climates but occurs in every region of the United States and throughout the world. If the disease becomes persistent (chronic), it can keep the body from absorbing nutrients, a condition known as a malabsorption syndrome. Infection is usually spread through drinking contaminated water or, less commonly, via person-to-person contact (such as in day care centers).
Another intestinal parasite, called Cryptosporidium parvum, causes watery diarrhea that is sometimes accompanied by abdominal cramps, nausea, and vomiting. The resulting infection, called cryptosporidiosis, is usually mild in otherwise healthy people, but it may be severe or even fatal in people with a weakened immune system. It is most commonly acquired by drinking contaminated water. Because it is resistant to chlorine, this parasite is the most common cause of recreational water illness in the United States.
Other parasites that can cause symptoms similar to those of cryptosporidiosis include Cyclospora cayetanensis and, in people with an impaired immune system, Isospora belli and a collection of organisms referred to as microsporidia. Entamoeba histolytica causes amebiasis, an infection of the large intestine and sometimes the liver and other organs. Amebiasis is a common cause of bloody diarrhea in developing countries but is rare in the United States.
Chemical Gastroenteritis:
Gastroenteritis may result from ingesting chemical toxins . These toxins are usually produced by a plant, such as poisonous mushrooms, or by certain kinds of exotic seafood and thus are not the product of an infection. Gastroenteritis due to chemical toxicity can also occur after ingesting water or food contaminated by chemicals such as arsenic, lead, mercury, or cadmium. Heavy-metal poisoning frequently causes nausea, vomiting, abdominal pain, and diarrhea. Eating large amounts of acidic foods, such as citrus fruits and tomatoes, gives some people gastroenteritis.
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| Microorganisms That Cause Gastroenteritis |
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Microorganism
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Common Sources
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Symptoms
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Antimicrobial Use
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Campylobacter
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Eating contaminated meat (especially undercooked poultry)
Drinking contaminated water or unpasteurized milk
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Often bloody, sometimes watery diarrhea lasting 1 day to a week or more
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Antibiotics given in the early stages of illness may shorten the duration of symptoms (for example, azithromycin or ciprofloxacin).
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Salmonella
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Eating contaminated food
Contact with reptiles (for instance, iguanas, snakes, and turtles), birds, or amphibians (for instance, frogs and salamanders)
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High fever, exhaustion, abdominal cramps, nausea, vomiting, diarrhea that may or may not be bloody
Symptoms usually last 3 to 7 days
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Antibiotics usually are not given.
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Shigella
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Person-to-person contact, especially in day care centers
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May be mild or severe
In mild cases, watery, loose stools
In severe cases, high fever, exhaustion, severe abdominal cramps, painful passage of stool containing blood and mucus
Symptoms usually last about a week without treatment
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Antibiotics shorten the duration of the illness and decrease chance of spread to another person (for example, ciprofloxacin or trimethoprim-sulfamethoxazole).
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EnterohemorrhagicEscherichia coli (most commonly E. coli O157:H7―see Gastroenteritis: Hemorrhagic Colitis)
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Eating undercooked ground beef or drinking unpasteurized milk or juice
Swimming in contaminated pools
Person-to-person contact
Touching infected animals and then putting fingers in the mouth
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Sudden abdominal cramps, watery diarrhea that usually becomes bloody within 1 to 3 days, and hemolytic-uremic syndrome
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Antibiotics are not given.
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Clostridium difficile
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Usually due to bacterial overgrowth in people who have been taking antibiotics
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Diarrhea
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Antibiotic that caused the illness is stopped.
Metronidazole or vancomycin is given by mouth.
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Entamoeba histolytica
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Eating or drinking contaminated food or water
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Bloody diarrhea, abdominal pain, weight loss lasting 1 to 3 weeks
Can cause infection in liver and other organs
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Antiparasitic drugs are given (for example, metronidazole, iodoquinol, or paromomycin).
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Enterotoxigenic Escherichia coli (causes traveler's diarrhea)
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Eating or drinking contaminated food or water
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Frequent watery diarrhea
Usually lasts 3 to 5 days
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Antibiotics (for example, ciprofloxacin or levofloxacin) may help shorten duration of illness.
Azithromycin is given to children.
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Vibrio cholerae
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Eating or drinking contaminated food or water
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Painless, watery diarrhea and vomiting
Can lead to massive fluid loss and shock
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Antibiotics are given (for example, ciprofloxacin or doxycycline).
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Other types of Vibrio
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Shellfish
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Watery diarrhea, often with little nausea or vomiting
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Antibiotics are given (for example, ciprofloxacin, doxycycline, or trimethoprim/sulfamethoxazole).
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Staphylococcus aureus
Bacillus cereus
Clostridium perfringens
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Eating food contaminated by toxins produced by bacteria
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Severe nausea, vomiting, and diarrhea
Symptoms begin within 12 hours after eating contaminated food and lessen within 36 hours
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Antibiotics are not given.
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Rotavirus
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Epidemic and often seasonal
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Frequent watery diarrhea
Vomiting and fever higher than 102° F (about 39° C)
Symptoms begin 1 to 3 days after infection
May last 5 to 7 days
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Antibiotics and antiviral drugs are not given.
Vaccines are available for infants.
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Norovirus
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Epidemic and often seasonal
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Frequent watery diarrhea
Vomiting occurs in 90% of people
Stomach cramps, headache, and aches and pains
Fever higher than 102° F (about 39° C) occurs in about 30% of people
Diarrhea usually affects adults
Symptoms begin 1 to 2 days after infection
Usually lasts 2 to 7 days
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Antibiotics and antiviral drugs are not given.
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Astrovirus
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Epidemic and often seasonal
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Milder watery diarrhea
Vomiting and fever
Symptoms begin 3 to 4 days after infection
Usually lasts 2 to 7 days
Similar to rotavirus
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Antibiotics and antiviral drugs are not given.
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Intestinal adenovirus
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Epidemic and often seasonal
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Frequent watery diarrhea lasts 1 to 2 weeks
Mild vomiting begins 1 to 2 days after diarrhea
Fever affects 50% of people
Symptoms begin 3 to 10 days after infection
Usually lasts 10 days or more
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Antibiotics and antiviral drugs are not given.
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Giardia
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Drinking contaminated water
Person-to-person contact, particularly in day care centers
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Diarrhea, nausea, and loss of appetite
More long-term illness (lasting several days to several weeks) may occur, with greasy stools, abdominal bloating, gas, fatigue, and weight loss
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Antiparasitic drugs are given (for example, metronidazole or nitazoxanide).
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Cryptosporidium
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Drinking contaminated water
Person-to-person contact
Recreational water exposure
People with impaired immune systems are particularly susceptible
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Watery diarrhea, crampy abdominal pain, nausea, fatigue, and vomiting
Usually lasts about 2 weeks
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Antiparasitic drugs are sometimes given (for example, nitazoxanide).
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Symptoms
The type and severity of the symptoms depend on the type and quantity of microorganism or toxin ingested. Symptoms also vary according to the person's resistance. Symptoms often begin suddenly—sometimes dramatically—with a loss of appetite, nausea, or vomiting. Audible rumbling of the intestine and abdominal cramping may occur. Diarrhea is the most common symptom and may be accompanied by visible blood and mucus. Loops of intestine may be painfully swollen (distended) with gas. The person may have a fever, feel generally sick, and experience aching muscles and extreme exhaustion.
Severe vomiting and diarrhea can lead to marked dehydration (see Water Balance: Dehydration). Symptoms of dehydration include weakness, decreased frequency of urination, dry mouth, and, in infants, lack of tears when crying. Excessive vomiting or diarrhea can result in low levels of potassium in the blood (hypokalemia). Low blood pressure and a rapid heart rate can also develop. Low levels of sodium in the blood (hyponatremia) also may develop, particularly if the person replaces lost fluids by drinking fluids that contain little or no salt, such as water and tea. Water and electrolyte imbalances are potentially serious, especially in the young, the old, and people with chronic diseases. Shock and kidney failure can occur in severe cases.
Diagnosis
The diagnosis of gastroenteritis is usually obvious from the symptoms alone, but the cause often is not. Sometimes other family members or coworkers have recently been ill with similar symptoms. Other times, gastroenteritis can be traced to contaminated water or inadequately cooked, spoiled, or contaminated food, such as raw seafood or mayonnaise left out of the refrigerator too long. Recent travel, especially to certain foreign countries, and recent antibiotic use may give clues as well.
If the symptoms are severe or last for more than 48 hours, stool samples may be cultured and examined in a laboratory for white blood cells and bacteria, viruses, or parasites.
If the symptoms persist beyond a few days, a doctor may need to examine the large intestine with a sigmoidoscope (a flexible viewing tube used to view the lower part of the digestive tract) to determine whether the person has a disease such as ulcerative colitis.
Prevention
Two rotavirus vaccines given by mouth are available and are safe and effective against most strains of rotavirus. Rotavirus vaccination is part of the recommended infant vaccination schedule (see Newborns and Infants: Vaccinating Infants and Children ).
For infants, a simple and effective way to help prevent gastroenteritis is breastfeeding. Caregivers should wash their hands thoroughly with soap and water after changing diapers, and diaper-changing areas should be disinfected with a freshly prepared solution of household bleach (¼ cup bleach diluted in 1 gallon of water). Children with diarrhea should be excluded from day care centers for the duration of their symptoms. Children infected with E. coli that causes bloody diarrhea or Shigella should also have two negative stool cultures before they are allowed to return to the center.
Infants and other people with a weakened immune system should not be exposed to reptiles, birds, or amphibians, because these animals typically carry Salmonella bacteria.
Because most infections that cause gastroenteritis are transmitted by person-to-person contact, particularly through direct or indirect contact with infected stool, good hand washing with soap and water after a bowel movement is the most effective means of prevention. To prevent foodborne infections, hands should be washed before touching food, knives and cutting boards used to cut raw meat should be washed before use with any other food, meat and eggs should be cooked thoroughly, and leftovers should be refrigerated promptly after cooking. Only pasteurized dairy products and pasteurized apple juice should be used. Travelers should try to avoid high-risk foods and beverages, such as those sold by street vendors.
To prevent recreational water illness, people should not swim if they have diarrhea. Infants and toddlers should have frequent diaper checks and should be changed in a bathroom and not near the water. Swimmers should avoid swallowing water when they swim.
Treatment
Usually the only treatment needed for gastroenteritis is getting bed rest and drinking an adequate amount of fluids. Even a person who is vomiting should drink as much as can be tolerated, taking small frequent sips. If vomiting or diarrhea is prolonged or the person becomes severely dehydrated, fluids and electrolytes given by vein (intravenously) may be needed. Because children can become dehydrated more quickly, they should be given fluids with the appropriate mix of salts and sugars. Any of the commercially available solutions designed to replace lost fluids and electrolytes (rehydration solutions) are satisfactory. Carbonated beverages, teas, sports drinks, beverages containing caffeine, and fruit juices are not appropriate. If the child is breastfed, breastfeeding should continue. Drugs that control severe vomiting are not generally given to young children. For adults, a doctor may give a drug, either as an injection or as a suppository, to control severe vomiting.
As the symptoms subside, the person may gradually add foods to the diet. There is no need to limit the diet to bland foods such as cereal, gelatin, bananas, rice, applesauce, and toast. However, some people are unable to tolerate milk for a few days after having diarrhea.
If the diarrhea continues for 24 to 48 hours and there is no blood in the stool to indicate a more serious bacterial infection, the doctor may prescribe a drug to control the diarrhea, such as diphenoxylate, or instruct the person to use an over-the-counter drug, such as loperamide. Again, these drugs usually are not given to children under the age of 5.
Because antibiotics can cause diarrhea and may encourage the growth of organisms resistant to antibiotics, they are rarely appropriate, even when a known bacterium is causing gastroenteritis. Antibiotics may be used, however, when certain bacteria, such as Campylobacter, Shigella, and Vibrio, are the cause, and for people who have traveler's diarrhea.
Parasitic infections are treated with antiparasitic drugs such as metronidazole and nitazoxanide.
Some bacteria are naturally found in the body and promote the growth of good bacteria (probiotics). The use of probiotics, such as lactobacillus (typically present in yogurt) may slightly shorten the duration of diarrhea (perhaps by less than a day). However, probiotics probably do not prevent more serious consequences of gastroenteritis such as the need for intravenous fluids or for hospitalization.
Last full review/revision August 2012 by Thomas G. Boyce, MD, MPH
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