Drugs: Merck Manual Home Edition

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Drugs

Overview of Drugs

	Overview of Drugs
	Drug Design and Development
	Placebos
	Drug Effectiveness and Safety

Administration and Kinetics of Drugs

	Introduction
	Drug Administration
	Drug Absorption
	Drug Distribution
	Drug Metabolism
	Drug Elimination

	Definition of Drug Dynamics
	Site Selectivity
			Receptors on Cells
			Enzymes
	Drug Action
			Reversibility
			Affinity and Intrinsic Activity
			Potency and Efficacy

Factors Affecting Response to Drugs

	Overview of Response to Drugs
	Genetic Makeup and Response to Drugs
	Drug Interactions
		Drug-Drug Interactions
		Drug-Nutrient Interactions
		Drug-Disease Interactions
	Tolerance and Resistance to Drugs
			Prevention and Treatment

Adverse Drug Reactions

	Overview of Adverse Drug Reactions
	Types of Adverse Drug Reactions
	Severity of Adverse Drug Reactions
	Benefits Versus Risks of Drugs
	Risk Factors for Adverse Drug Reactions
			Use of Several Drugs
			Age
			Pregnancy and Breastfeeding
	Allergies to Drugs
	Overdose Toxicity

Adherence to Drug Treatment

	Adherence to Drug Treatment
			Results of Not Adhering
			Children and Adherence
			Older People and Adherence
			Improving Adherence

Trade-Name and Generic Drugs

	Overview of Generic Drugs and Drug Naming
			Patent Protection
			Nonprescription Generic Drugs
	Bioequivalence and Interchangeability of Generic Drugs
	Generic Biologic Drugs

Over-the-Counter Drugs

	Overview of Over-the-Counter Drugs
			Historical Background
			Safety Considerations
	Precautions With Over-the-Counter Drugs
		Children
		Older People
		Pregnant and Breastfeeding Women
		People With Chronic Disorders
		Drug-Drug Interactions
		Drug Overlap

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