Not Found

Find information on medical topics, symptoms, drugs, procedures, news and more, written in everyday language.

Malignant External Otitis

(Skull Base Osteomyelitis; Necrotizing Otitis Externa)

By Bradley W. Kesser, MD, Professor, Department of Otolaryngology - Head and Neck Surgery, University of Virginia School of Medicine

Malignant external otitis is infection of the external ear that has spread to the skull bone (temporal bone) containing the ear canal, the middle ear, and the inner ear.

Malignant external otitis occurs mainly in people with a weakened immune system and in older people with diabetes. Infection of the external ear, usually caused by the bacteria Pseudomonas,spreads into the temporal bone, causing severe, life-threatening infection. Methicillin-resistant Staphylococcus aureus (MRSA) has also been identified as a cause. Despite the name, the infection is notcancerous (malignant).


People have severe ear pain (often worse at night), a foul-smelling discharge from the ear, pus and debris in the ear canal, and usually decreased hearing. In severe cases, paralysis of nerves in the face and head may occur as the infection spreads along the base of the skull.


  • Computed tomography (CT) scan

  • Culture of discharge

  • Biopsy

The diagnosis is based on CT scan results. Doctors also do a culture (a sample of the discharge is grown in a laboratory to identify the microorganisms). Often doctors need to take a small piece of tissue from the ear canal and examine it under a microscope (biopsy) to make sure that the symptoms are not caused by cancer.


  • Antibiotics

  • Sometimes hyperbaric oxygen therapy

  • Control of diabetes

  • Repeated cleanings of the ear canal

Typically, malignant external otitis is treated with a 6-week course of antibiotics given by vein. However, people with a mild infection may be treated with high doses of an antibiotic such as ciprofloxacin taken by mouth. Some people may be treated in a high-pressure oxygen chamber (hyperbaric oxygen therapy). People who have extensive bone disease may require antibiotic therapy for a longer period.

Meticulous control of diabetes is essential.

Although surgery usually is not necessary, repeated cleanings of and removal of dead skin and inflammatory tissue (debridement) in the ear canal in the doctor's office are necessary until the infection goes away.

Drugs Mentioned In This Article

  • Generic Name
    Select Brand Names