Merck Manual

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Submandibular Space Infection

(Ludwig's Angina; Ludwig Angina)

By

Alan G. Cheng

, MD, Stanford University

Reviewed/Revised Feb 2024
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Topic Resources

A submandibular space infection is a bacterial infection of the tissues below the mouth.

  • Submandibular space infection can cause pain and tenderness under the tongue and/or under the jaw, and swelling that may block the airway

  • Doctors can usually diagnose submandibular space infection by examining the mouth, but computed tomography is sometimes needed.

  • Doctors insert a breathing tube to keep the airway open and give antibiotics.

Bacteria can spread from an infected lower tooth to the tissue under and around the tongue. People with poor dental hygiene and people who have had a tooth pulled or a jaw fracture are at higher risk. The infection causes swelling that can block the airway causing difficulty breathing and sometimes death.

Symptoms of Submandibular Space Infection

People with a submandibular space infection have pain and tenderness under the tongue and/or under the jaw. The pain is worse with opening the mouth or swallowing.

Fever and chills are common.

Later, swelling worsens, which may cause drooling, and people may make a sound (for example, squeaking or gasping) when they breathe in (called stridor Stridor Stridor is a gasping sound during inhalation resulting from a partial blockage of the throat (pharynx), voice box (larynx), or windpipe (trachea). Stridor is usually loud enough to be heard... read more ). Once swelling occurs, blockage of the airway and death may occur within hours.

Diagnosis of Submandibular Space Infection

  • A doctor's evaluation

  • Sometimes computed tomography

Doctors usually can diagnose submandibular space infection by examining the mouth.

If the examination is unclear, computed tomography (CT) is done. However, if an airway blockage appears to be developing or may occur soon, treatment is started quickly, and CT is postponed.

Treatment of Submandibular Space Infection

  • A breathing tube followed by surgery to drain the infected area

  • Antibiotics

Treatment for submandibular space infection must be done quickly to prevent blockage of the airway.

Doctors take the person to the operating room and use a thin, flexible viewing (fiberoptic) tube to help guide a plastic breathing tube through the nose into the windpipe (trachea) to keep the airway open. Then doctors surgically open the infected area to allow the infection to drain.

If a breathing tube cannot be placed, a tracheotomy is done.

Antibiotics such as ceftriaxone and clindamycin are given by vein.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Ceftrisol Plus, Rocephin
Cleocin, Cleocin Ovules, Cleocin Pediatric, Cleocin T, CLIN, Clindacin ETZ, Clindacin-P, Clinda-Derm , Clindagel, ClindaMax, ClindaReach, Clindesse, Clindets, Evoclin, PledgaClin, XACIATO
NOTE: This is the Consumer Version. DOCTORS: VIEW PROFESSIONAL VERSION
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