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Any or all of the structures within the orbit may become inflamed.
Causes
Inflammation of the orbit can be the result of a bodywide (systemic) inflammatory disorder. Sometimes the inflammation affects only the eye.
Systemic inflammatory disorders that affect the eye include Wegener's granulomatosis, in which there is generalized inflammation of blood vessels (called vasculitis). Inflammatory disorders that affect only the eye include scleritis, in which the white coat of the eye (sclera) becomes inflamed. Eyelid disorders with inflammation are discussed elsewhere (see Eyelid and Tearing Disorders). Inflammation affecting the lacrimal gland, located at the upper outer edge of the orbit (see Eyelid and Tearing Disorders:Overview of the Eyelids and Tears ), is called inflammatory dacryoadenitis. Inflammation that affects one of the muscles that move the eye is called myositis. Inflammation affecting the entire orbit and its contents is called inflammatory orbital pseudotumor (which is not really a tumor and is not a cancer) or nonspecific orbital inflammation.
Symptoms
Symptoms vary depending on which structures are actually inflamed. In general, symptoms start rather suddenly, typically over a few days. Pain and redness of the eyeball or eyelid occur. Pain can be severe and incapacitating at times. Abnormal bulging of the eyes (proptosis), double vision, and vision loss are also possible.
Diagnosis
Computed tomography (CT) or magnetic resonance imaging (MRI) is done. A doctor may take a sample from the inflamed area for examination under a microscope (biopsy) to determine the cause.
Treatment
Many disorders causing inflammation are treated with a corticosteroid drug, which can be given by mouth. Corticosteroids can be given by vein (intravenously) if the inflammation is severe. Radiation therapy or drugs and treatments that change the body's immune responses (for example, methotrexate or cyclophosphamide) may sometimes be used.
Last full review/revision September 2008 by James Garrity, MD
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