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Prevention includes four major tools. One tool is establishing a healthful lifestyle, which includes habits such as wearing a seat belt, eating a healthy diet, getting enough physical exercise, wearing sunscreen, and not smoking. Another tool is getting vaccinated to prevent infectious diseases such as influenza, pneumococcal pneumonia, and childhood infections. A third tool is participating in screening efforts so that diseases such as high blood pressure and cancer are detected early. The fourth tool is taking drug therapy recommended to prevent disorders from developing or worsening (preventive drug therapy, also known as chemoprevention) for people at high risk. Examples of chemoprevention include cholesterol-lowering drugs to prevent atherosclerosis, aspirin to prevent heart attacks or strokes, tamoxifen to prevent breast cancer, and antihypertensive drugs to reduce blood pressure and prevent strokes.
Healthful Lifestyle
Lifestyle and disease are clearly linked. Particular lifestyle changes can help prevent particular disorders. Also, some lifestyle changes improve fitness and quality of life and decrease risks of many different disorders. For example, the three leading causes of death in the United States—heart disease, cancer, and stroke—are more likely to occur in people who make poor lifestyle choices, especially eating a diet high in calories, saturated fats, trans fatty acids, and cholesterol (such a diet increases the risk of having high cholesterol levels in the blood); not exercising regularly; and smoking. By having informative discussions with doctors and other health care practitioners, people can make good decisions and establish healthful habits. Establishing and maintaining a healthful lifestyle can be done only by the person. Consistently eating a healthy diet and getting enough exercise are difficult for many people. However, doing so can prove to be exciting, rewarding, and affordable. Some important parts of maintaining a healthful lifestyle follow.
Healthful eating habits can help people prevent or control diseases such as high blood pressure, heart disease, diabetes, osteoporosis, and certain cancers. A diet that includes plenty of vegetables, fruits, and whole-grain cereals and breads is recommended, in part because such a diet is high in fiber (see Overview of Nutrition: Fiber). Cutting down on harmful types of fat (saturated fats and trans fatty acids—see Overview of Nutrition: Fats) and instead eating fish, skinless poultry, and very lean meat and choosing low-fat dairy foods are recommended as well. Calories are best limited to maintain a recommended body weight. Limiting salt and getting adequate amounts of calcium and vitamin D are also recommended.
Physical activity and exercise can help prevent obesity, high blood pressure, heart disease, stroke, diabetes, some types of cancer, constipation, falls, and other health problems. The best routine includes moderate physical activity for 60 minutes or more on all or most days of the week. However, getting even a little bit of exercise is much better than none at all. For example, people who can devote only 10 minutes at a time to physical activity may still reap important benefits, particularly if the exercise is vigorous or if they repeat the activity throughout the day (see Exercise and Fitness: Benefits of Exercise). Walking is one simple, effective exercise that many people enjoy. Certain types of exercise can also target specific problems. For example, stretching improves flexibility, which can help prevent falls. Aerobic exercise may decrease the risk of heart attacks and angina.
Quitting smoking is important to a healthful lifestyle. A doctor can offer encouragement and advice on ways to successfully quit smoking, including information and recommendations on the use of nicotine replacement products, bupropion and varenicline (drugs that help reduce cravings), and other tools (see Drug Use and Abuse: Treatment).
Safe sex practices remain important. Key safe sex practices are avoiding risky sex partners and remaining mutually monogamous. People who have more than one sex partner can greatly reduce their risk of contracting a sexually transmitted disease by using a latex condom properly every time they have sex (see Sexually Transmitted Diseases: How to Use a Condom ). People who are allergic to latex can use other kinds of condoms.
Limiting alcohol use is important. Although small amounts of alcohol, particularly red wine, may have some health benefits, drinking more than moderate amounts (for example, 1 to 2 drinks per day, possibly less for women) is often harmful (see Drug Use and Abuse: Alcohol). Each drink is about 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of more concentrated liquor, such as whiskey.
Injury prevention plays a major role in maintaining a healthful lifestyle. For example, people can lower their risk of injury by taking certain precautions.
Adequate sleep is also an important part of a healthful lifestyle, particularly affecting mood and mental state. Insufficient sleep is a risk factor for injuries.
Vaccination
Vaccines have been enormously successful. Dangerous and sometimes fatal infectious diseases such as diphtheria, pertussis, tetanus, mumps, measles, rubella, and polio have decreased by more than 99% from their peak number of cases, thanks to the availability of effective and safe vaccines and their widespread use. Furthermore, vaccinations save about $14 in health care costs for every $1 spent.
Many side effects have been attributed to vaccines. Actual side effects that occur depend on the vaccine, but common side effects are usually minor, such as swelling, soreness, allergic reactions at the injection site, and sometimes fever or chills. More serious side effects can occur, such as autoimmune reactions (for example, Guillain-Barré syndrome, which causes temporary weakness or paralysis). However, serious side effects are very rare if vaccines are given properly. Through systematic and extensive research, vaccines have not been linked to other serious side effects such as autism. Reports that vaccines cause side effects such as AIDS and sterility are “urban legends” that have no factual basis in developed countries. (If contaminated needles are improperly reused, however, infectious diseases can be spread, but this infection is not caused by a vaccine.) People who refuse vaccination to avoid complications place their health at much greater risk from the infection that the vaccine is designed to prevent.
Children and adolescents, older adults, and people whose immune system is impaired are often the most vulnerable to developing vaccine-preventable infections. They are also often the most vulnerable to developing serious symptoms from those infections. For example, whooping cough (pertussis) can develop in people of any age but may be mistaken for a cold in otherwise healthy people because the symptoms are so mild. Although it is most important to vaccinate the most vulnerable people, vaccinating other people is also important. Doing so prevents illness in the vaccinated person and also decreases the number of people in the community who could develop and thus transmit infection to more vulnerable people. Thus, deaths and serious complications in the community are reduced by vaccinating as many people as possible. This effect is called herd immunity. See Newborns and Infants: Vaccination of Infants and Children for an in-depth discussion on vaccination.
Screening
Screening is testing of people who are at risk of a disorder but do not have any symptoms. Screening can allow for early treatment, sometimes keeping disorders from turning deadly. For example, abnormalities of the cervix or colon can be diagnosed and cured before they turn cancerous. Screening programs have greatly reduced the number of deaths associated with some disorders. For example, deaths due to cervical cancer, once the most common cause of cancer death among American women, have decreased 75% since 1955. Screening can also diagnose disorders that are not curable but that can be treated before they cause too much damage (for example, high blood pressure).
People might think that any test capable of diagnosing a serious disorder should be performed. However, this is not true. Although screening can offer great benefits, it can also create problems. Some screening tests have a small risk of causing harm (for example, a colonoscopy can perforate or tear the colon). If such a test is performed on a large number of people who do not have any disease, then the small number of people who have the complication can outweigh the even smaller number who benefit by having the disease diagnosed. Similarly, because test results are sometimes positive in people who do not have disease, a certain number of people undergo unnecessary (and expensive and possibly painful or dangerous) tests or treatment in follow-up. Also, sometimes screening reveals abnormalities that cannot or need not be treated. For example, prostate cancer often grows so slowly that in older men the cancer is unlikely to affect their health before they die from another cause. In such cases, the treatment can be worse than the disease. Whole-body computed tomography scans are not recommended because they do not have benefits (such as saving lives) that exceed the risks (such as disorders caused by the radiation exposure, including cancer). In addition, when people are told they could have a serious disorder, they can become anxious, which can affect health. Because of these issues, screening is recommended only when
Some screening tests (such as tests for cervical and colon cancers) are recommended for all people of a certain age or sex. For people at increased risk because of other factors, tests may be recommended at an earlier age or at more frequent intervals or additional tests may be recommended. For example, a person with a family history of colorectal cancer or with a disease that increases the chances of developing colorectal cancer, such as ulcerative colitis, would be advised to undergo a screening colonoscopy more often than is normally recommended for people at average risk. A woman with a strong family history of breast cancer would likely be advised to undergo screening mammography at an earlier age. Some screening measures are recommended for people with certain disorders. For example, people with diabetes should check their feet at least once daily for redness and ulcers, which, if ignored, may potentially result in severe infection and ultimately amputation.
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| Selected Screening Schedule for Adults*,† |
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Condition
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Test
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For
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How Often
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Abdominal aortic aneurysm
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Abdominal ultrasonography
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Men age 65 to 75 who smoke or have previously smoked
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Once
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Alcohol misuse
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Questioning
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Adults
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Once and periodically, such as if circumstances change (for example, when under new stresses or if lifestyle changes)
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Amblyopia and strabismus
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Vision testing and eye examination
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Children age 5 or younger
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Once
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Breast and ovarian cancers
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Genetic counseling and possible genetic testing for BRCA mutation, which indicates increased risk for breast and ovarian cancers
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Women with a strong family history of breast cancer (see Breast Disorders: Risk Factors for Breast Cancer ) or ovarian cancer (see Cancers of the Female Reproductive System: Ovarian Cancer)
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Once
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Breast cancer
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Mammography and clinical breast examination
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Women 40 and older
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Every 1 to 2 years
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Cervical cancer
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Papanicolaou (Pap) test or liquid cervical cytology test
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All women who have ever been sexually active and have not had their cervix removed
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Every 1 to 3 years
Most women can stop having Pap tests after age 65
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Chlamydial infection
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Culture or DNA test
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Sexually active women age 25 or younger or who have risk factors (such as multiple sex partners or a sexually transmitted diseases)
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Once and periodically, such as when circumstances change (for example, new sex partners or after becoming pregnant)
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Colorectal cancer
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Colonoscopy or other testing (such as virtual colonoscopy or computed tomography scan)
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Adults age 50 or older
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Every 5 to 10 years
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Dental problems
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Check-up with dentist
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All
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Every 3 to 12 months for those under age 18
Every 3 to 24 months for age 18 and older
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Depression
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Questioning
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Adults
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Once and periodically, such as during stressful circumstances (for example, divorce, job or lifestyle change, or death in the family)
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Diabetes
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Blood tests to measure blood sugar level
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Adults who are overweight or with high blood pressure or high levels of lipids in their blood
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At least once
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Glaucoma
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Eye examination and eye pressure test
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Adults age 40 and older
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Every 2 to 4 years for adults age 40 to 64
Every 1 to 2 years for those age 65 and older
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Gonorrhea
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Culture or tests such as DNA testing
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Pregnant women and young women who are sexually active
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Once and periodically, such as when circumstances change (such as with new sex partners or after becoming pregnant)
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Hearing loss
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Hearing tests
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Adults age 65 or older
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Yearly
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Hemolytic disease of the newborn
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RhO(D) incompatibility screening
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Pregnant women
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First prenatal visit; for most RhO(D)-negative women, test again at 24 to 28 weeks of pregnancy
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Hepatitis B
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Blood test for infection with the virus
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Pregnant women
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At first prenatal visit
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High blood pressure (hypertension)
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Blood pressure measurement
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Adults
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Every office visit or annually
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High levels of lipids (fats) and cholesterol in the blood
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Blood tests to measure lipid (including cholesterol) levels
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Men age 35 and older and women age 45 and older
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Every 5 years; more often if levels are abnormal
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Human immunodeficiency virus (HIV) infection, including AIDS
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Blood test for infection with the virus
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Adolescents and adults at risk of HIV infection and all pregnant women
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Once and if new high-risk activity occurs (for example, those with multiple sex partners or injection drug use and in men having sex with men)
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Osteoporosis
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Dual x-ray absorptiometry (DEXA scan) to measure bone density
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Women age 60 and older who are at risk for osteoporotic fractures and all women age 65 and older (see Osteoporosis: Diagnosis)
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At least once
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Overweight in adults and children; growth disturbance in children
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Measurement of height and weight
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All
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Weight: Every scheduled office visit or annually
Height: Every scheduled office visit in children and adolescents
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Refractive errors (poor vision)
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Vision testing (screening exams do not require an optometrist or ophthalmologist)
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All
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Once for age 0 to 6 months
Once at age 3
Every 2 years for age 6 to 17
Every 2 to 3 years for age 18 to 40
Every 2 years for age 41 to 60
Every year for age 61 and older
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Syphilis
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Blood test
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Adults with risk factors (such as multiple sex partners or a previous sexually transmitted disease), all pregnant women, and those who have other diagnosed sexually transmitted diseases
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Once and periodically, such as when circumstances change (such as with new sex partners or after becoming pregnant)
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Tobacco use
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Questioning
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Adolescents and adults
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Every office visit
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*Based on recommendations by most major authorities in the United States. However, differences do exist among their recommendations.
†Screening measures that can be done at home include regularly measuring weight and, once yearly, checking skin for signs of change and for bleeding skin lesions, perhaps having another person (such as a spouse) look at locations that are difficult to see, such as the back or behind the ears.
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Preventive Drug Therapy
Preventive drug therapy (also known as chemoprevention) is the use of drugs to prevent disease. For such therapy to be recommended, the person must be at risk of the disorder being prevented and be at low risk of side effects caused by the drug being considered. Preventive drug therapy is clearly helpful in, for example, prevention of infection in people with certain disorders (such as AIDS), prevention of headache in people with migraines, and many other specific situations. Although preventive drug therapy is effective only in specific situations, some of those situations are common, so the therapy is useful for many people. For example, for adults at risk of coronary artery disease or stroke, aspirin is usually recommended. Newborns routinely receive eye drops to prevent gonococcal infection of the eyes. Women who are at high risk of breast cancer may benefit from preventive drug therapy (for example, with the drug tamoxifen).
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| Selected Strategies for Preventing Some Major Health Problems* |
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Health Problem
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Preventive Measures
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Heart disease
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Maintain normal lipid and cholesterol levels through diet and drugs (if necessary)
Maintain normal blood pressure through diet, exercise, stress reduction, and drugs (if necessary)
Consume a balanced diet high in fiber and limited in fat, cholesterol, and calories
Avoid smoking
Undergo sufficient regular exercise
Take aspirin if recommended (most adults at high risk of coronary artery disease)
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Cancer
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Avoid smoking (lung cancer)
Eat a balanced diet high in fiber and limited in fat, cholesterol, and calories (breast cancer, colorectal cancer)
Avoid too much sun exposure and use sunscreens with a high sun-protection factor (skin cancer)
Take recommended chemoprevention such as tamoxifen (women at high risk of breast cancer and who choose to do this)
Get recommended screening tests
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Stroke
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Avoid smoking
Maintain normal blood pressure through diet, exercise, stress reduction, and drugs (if necessary)
Maintain normal cholesterol through diet, exercise, and drugs (if necessary)
Avoid cocaine
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Chronic obstructive pulmonary disease
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Avoid smoking
Avoid exposure to toxic substances (especially in industrial settings)
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Diabetes
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Exercise regularly
Eat a balanced diet
Maintain recommended body weight
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Osteoporosis
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Consume adequate amounts of calcium and vitamin D
Do weight-bearing exercises (for example, walking, jogging, tennis, dancing) every day for at least 30 minutes
Take bone-strengthening drugs if prescribed by a doctor
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Pneumonia
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Receive pneumonia (pneumococcal) vaccine once, repeated once after 5 years for those at high risk, including those over age 65
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Influenza
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Receive influenza vaccine every year (particularly infants, older adults, and people who have heart, lung, or immune system disorders)
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Tooth loss
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Brush teeth and use dental floss regularly
Avoid frequent sweets
Visit a dentist regularly
Take supplemental fluoride (preschool children older than 6 months whose water source is fluoride-deficient)
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Sexually transmitted diseases
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Practice abstinence or limit the number of sex partners
Use condoms and follow safe sex practices
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Liver disease
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Drink alcohol in moderation if at all
Receive vaccination against hepatitis A and B (all children and high-risk adults)
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*In addition to these preventive measures, people should undergo recommended screening tests (see Prevention: Selected Screening Schedule for Adults*,† ).
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Last full review/revision September 2007 by James T. Pacala, MD, MS
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