(See also Overview of Abnormal Heart Rhythms.)
Cardiac channelopathies are genetic abnormalities in heart cell proteins that control heart electrical activity and thus can cause heart rhythm disturbances.
Most people who have cardiac channelopathies have no other heart disease, such as a heart attack or a heart valve disorder, but they carry mutations in the genes that determine the make-up or the regulation of heart membrane pores (channels) and are predisposed to heart rhythm abnormalities. The most common channelopathies cause
Other, more rare cardiac channelopathies include the following:
Some people never have any symptoms, but many people have fainting because of ventricular tachycardia. Those who have ventricular fibrillation have sudden cardiac arrest. Symptoms may be triggered by fever or treatment with some drugs, including some antiarrhythmic drugs and some antidepressants.
Electrocardiography (ECG) is used to make the diagnosis. But sometimes the pattern of ECG abnormalities is less clear. In such cases, doctors may try to provoke the heart rhythm disturbance with a drug or with exercise, enabling doctors to make a diagnosis.
Usually, an implantable cardioverter-defibrillator (ICD), a small device that can detect an arrhythmia and deliver a shock to correct it, is used. This procedure is similar to implantation of an artificial pacemaker.