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Oxazolidinones: Linezolid and Tedizolid

By Hans P. Schlecht, MD, MSc, Assistant Professor of Medicine, Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine
Christopher Bruno, MD, Assistant Professor of Medicine, Division of infectious Diseases & HIV Medicine, Drexel University College of Medicine

Oxazolidinones are a class of antibiotics used to treat serious infections, often after other antibiotics have been ineffective.

Oxazolidinones include the following:

  • Linezolid

  • Tedizolid

Oxazolidinones work by preventing bacteria from producing proteins they need to grow and multiply.



Common Uses

Some Side Effects


Serious infections caused by susceptible gram-positive bacteria (such as Staphylococcus and Streptococcus bacteria) that are resistant to many other antibiotics

Nausea and diarrhea


Anemia and low white blood cell and platelet counts

Numbness and tingling in the hands and feet (peripheral neuropathy)

Visual disturbances

Serotonin syndrome (confusion, agitation, tremors, or coma) in some people who also take selective serotonin-reuptake inhibitors


Complicated skin infections due to susceptible bacteria, including methicillin-resistant Staphylococcus aureus (MRSA)

Gastrointestinal upset


Anemia and a low white blood cell count

Use of Linezolid and Tedizolid During Pregnancy and Breastfeeding

Linezolid and tedizolid should used during pregnancy only if the benefits exceed the risk.

Whether linezolid and tedizolid are safe to use during breastfeeding is unknown.

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