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Influenza (Flu)

by Craig R. Pringle, BSc, PhD

Influenza (flu) is infection of the lungs and airways with one of the influenza viruses. It causes a fever, runny nose, sore throat, cough, headache, muscle aches (myalgias), and a general feeling of illness (malaise).

  • The virus is spread by inhaling droplets coughed or sneezed out by an infected person or by having direct contact with an infected person's nasal secretions.

  • Influenza often starts with chills, followed by a fever, muscle aches, headache, a sore throat, a cough, a runny nose, and a general feeling of illness.

  • People can often diagnose influenza themselves based on symptoms, but sometimes samples of blood or respiratory secretions must be analyzed to identify the virus.

  • An annual influenza vaccination is the best way to prevent influenza.

  • Resting, drinking plenty of fluids, and avoiding exertion can help, as can taking pain relievers, decongestants, and sometimes antiviral drugs.

Influenza is distinctly different from the common cold (see Common Cold). It is caused by a different virus and produces symptoms that are more severe. Also, influenza affects cells much deeper down in the respiratory tract.

The influenza virus is spread by inhaling droplets that have been coughed or sneezed out by an infected person or by having direct contact with an infected person's nasal secretions. Infection may be spread when people handle household articles that have been in contact with an infected person or an infected person's secretions.

Influenza types and strains

There are three types of influenza virus:

  • Type A

  • Type B

  • Type C

There are many different strains within types A and B influenza viruses but all cause similar illness. Different strains cause the regular seasonal outbreaks of flu. Type C does not cause a typical influenza illness.

Type A causes 95% of influenza cases, and most of the others are caused by type B. Type C influenza occurs less frequently, mainly in children.

The strain of influenza virus causing outbreaks is always changing slightly, so that each year the influenza virus is a little different from the previous year's. It often changes enough that previously effective vaccines no longer work.

Influenza type A strains are named based on the specific versions of two proteins present on the surface of the virus. The proteins are H (for hemagglutinin) and N (for neuraminidase). There are 18 different H proteins and 11 N proteins. Thus, a strain might be named influenza A, H1N1. This strain was responsible for many infections in the United States during the 2013-2014 flu season.

The name of a strain often reflects its type, the location where it first appeared (for example, Hong Kong flu) or an animal (for example, swine flu), and the year it was detected.

Influenza epidemics and pandemics

In an influenza epidemic , many people get sick within a very brief period of time. Every year, throughout the world, widespread outbreaks of influenza occur during late fall or early winter in temperate climates (called seasonal epidemics). Influenza epidemics may occur in two waves:

  • First, in schoolchildren and the people who live with them

  • Secondly, in people who are confined to home or who live in long-term care facilities, mainly older people

In each epidemic, usually only one strain of influenza virus is responsible for the disease.

An influenza pandemic refers to an outbreak that has spread across a large region, typically across continents and sometimes even worldwide. There have been only 6 major influenza pandemics since 1889. An influenza pandemic is concerning because it usually occurs only when there has been a larger than usual change in the strain of influenza virus. When such a large change occurs, that strain of influenza may affect many more people and cause more severe illness. The risk of death is higher. Although no one knows for certain, scientists think the 1918 influenza pandemic caused 30 to 50 million deaths worldwide, including about 675,000 in the United States.

Symptoms

Symptoms start 1 to 4 days after infection and can begin suddenly. Chills or a chilly sensation is often the first indication. Fever is common during the first few days, sometimes reaching 102 to 103° F (about 39° C). Many people feel so ill, weak, and tired that they remain in bed for days. They have aches and pains throughout the body, particularly in the back and legs. Headache is often severe, with aching around and behind the eyes. Bright light may make the headache worse.

At first, respiratory symptoms may be relatively mild. They may include a scratchy sore throat, a burning sensation in the chest, a dry cough, and a runny nose. Later, the cough can become severe and bring up phlegm (sputum). The skin may be warm and flushed, especially on the face. The mouth and throat may redden, the eyes may water, and the whites of the eyes may become bloodshot. People, especially children, may have nausea and vomiting. A few people lose their sense of smell for a few days or weeks. Rarely, the loss is permanent.

Most symptoms subside after 2 or 3 days. However, fever sometimes lasts up to 5 days. Cough, weakness, sweating, and fatigue may persist for several days or occasionally weeks. Mild airway irritation, which can result in a decrease in how long or hard a person can exercise, or slight wheezing may take 6 to 8 weeks to completely resolve.

Complications

The most common complication of influenza is

In viral pneumonia, the influenza virus itself spreads into the lungs. In bacterial pneumonia, unrelated bacteria (such as pneumococci or staphylococci) attack the person's weakened defenses. With either, people may have a worsened cough, difficulty breathing, persistent or recurring fever, and sometimes blood or pus in the sputum.

People at high risk of complications and death from influenza include

  • Children < 4 yr

  • Adults > 65 yr

  • People with chronic medical disorders (particularly those that affect the heart, lungs, or immune system) or diabetes mellitus

  • Women in the 2nd or 3rd trimester of pregnancy

  • Patients with disorders that increase their risk of choking on oral secretions, such as stroke or other neurologic disorders that cause weakness, and seizure disorders

Diagnosis

  • A doctor's evaluation

  • Sometimes tests on samples of blood or respiratory secretions

  • Sometimes a chest x-ray and measurement of oxygen levels in the blood

Because most people are familiar with the symptoms of influenza and because influenza occurs in epidemics, it is often correctly diagnosed by the person who has it or by family members. The severity of symptoms and the presence of a high fever and body aches help distinguish influenza from a common cold, especially when the illness occurs during an influenza outbreak. It is more difficult to correctly identify influenza by symptoms alone when no outbreak is occurring.

Tests on samples of blood or respiratory secretions can be used to identify the influenza virus. Such tests are done mainly when people appear very ill or when a doctor suspects another cause for the symptoms. Some tests can be done in the doctor's office.

If doctors suspect that pneumonia has developed, they take a chest x-ray and measure oxygen levels in the blood with a sensor placed on a finger (pulse oximetry).

Prevention

Prevention consists of

  • Vaccination each year for everyone 6 months of age or older

  • Sometimes antiviral drugs

Prevention is important for all people, but particularly for health care workers and those who are at high risk of complications of influenza.

Did You Know...

  • All people 6 months old and over, with rare exceptions, should get a flu vaccination each year.

Vaccines

Annual vaccination is the best way to avoid getting influenza.

There are two basic types of influenza vaccine (see Influenza Vaccine):

  • A vaccine that is given by injection and that contains inactivated (killed) influenza virus or pieces of the virus

  • A vaccine that is inhaled as a nasal spray and that contains weakened (attenuated) live viruses

The injected, inactivated vaccine can be given to all people aged 6 months old or older, including pregnant women. A higher-dose inactivated influenza vaccine is available for people over age 65. It is not given to

  • People who had a severe allergic reaction to any influenza vaccine or one of its components

The inhaled, live-virus vaccine is used only in healthy people aged 2 to 49 years. It is not given to

  • People who had a severe allergic reaction to any influenza vaccine or one of its components

  • Pregnant women

  • People with a weakened immune system (such as those who have AIDS or who take drugs that suppress the immune system) and those who live with them

  • People with certain other disorders such as asthma or a chronic lung, heart, or kidney disorder

  • Children who are taking aspirin over the long-term or who are under 5 years old and have asthma or another similar disorder

Doctors typically postpone giving either vaccine to people who are ill at the time of vaccination.

After the 1976 swine flu epidemic, in which millions of people received the influenza vaccine, a larger than usual number of people had a nerve disorder called Guillain-Barré syndrome (see Guillain-Barré Syndrome). At the time, doctors thought the vaccine triggered Guillain-Barré syndrome, but more recent evidence makes this connection uncertain. However, to be safe, doctors use caution when giving the influenza vaccine to anyone who developed Guillain-Barré syndrome within 6 weeks of receiving the influenza vaccine. In such cases, doctors and the person weigh the risk of the person's getting influenza against the risk of possibly developing Guillain-Barré syndrome.

People with a severe allergy to eggs may have a severe allergic reaction to the influenza vaccine because the vaccine is made from viruses grown in egg. However, a vaccine that does not contain egg is available for people aged 18 through 49 years.

Influenza vaccines usually protect against three different strains of influenza virus, but a new vaccine that protects against four strains is now available. The strains of virus that cause influenza outbreaks change each year. Thus, different vaccines are developed each year to keep up with changes in the virus. Experts try to predict the strain of virus that will attack each year based on the strain of virus that predominated during the previous influenza season and the strain causing disease in other parts of the world. When the H and N proteins in the vaccine match those in the influenza strains causing the current epidemic, the vaccine decreases the rate of infection by 70 to 90% in healthy adults.

In older people who live in long-term care facilities, the vaccine is less likely to prevent influenza, but it reduces the chances of developing pneumonia and of dying.

Other than occasional soreness at the injection site or, for the inhaled vaccine, a runny nose, side effects from the vaccine are rare.

In the United States, vaccination takes place during the fall so that levels of antibodies are highest during the peak influenza months: November through March. For most people, about 2 weeks is needed for the vaccination to provide protection.

Antiviral drugs

Although vaccination is the preferred method of prevention, several antiviral drugs can be used in certain people to prevent infection with the influenza virus.

During an outbreak of influenza, antiviral drugs are given to people who have been vaccinated within the previous 2 weeks (because it takes 2 weeks for the vaccine to become effective). They are stopped 2 weeks after people are vaccinated. These drugs are also given to people who have conditions that make vaccination ineffective or dangerous.

People may be given zanamivir or oseltamivir. Oseltamivir has few side effects. Zanamivir can irritate the lungs and cause wheezing in people who have asthma.

Treatment

  • Rest and plenty of fluids

The main treatment for influenza is to rest adequately, drink plenty of fluids, and avoid exertion. Normal activities may resume 24 to 48 hours after the body temperature returns to normal, but most people take several more days to recover.

People may treat fever and aches with acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin or ibuprofen. Because of the risk of Reye syndrome (see Reye Syndrome), children (aged 18 years and under) should not be given aspirin. Acetaminophen and ibuprofen can be used in children if needed. Other measures as listed for the common cold, such as nasal decongestants and steam inhalation, may help relieve symptoms (see Treatment).

The same antiviral drugs that prevent infection (oseltamivir and zanamivir) are also helpful in treating people who have influenza. However, these drugs work only if taken within the first day or two after symptoms begin, and they reduce severity of symptoms and shorten the duration of fever and the time to return to normal activities, but only by a day or so. Nevertheless, these drugs are very effective in some people.

Which drug or drugs are used depends on the specific influenza virus causing the infection. Oseltamivir, taken by mouth, and zanamivir, taken by inhaler, are effective against influenza type A and type B viruses.

If a bacterial infection develops, antibiotics are added.

Resources In This Article

Drugs Mentioned In This Article

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    Select Brand Names
  • No US brand name
  • RELENZA
  • TAMIFLU
  • ADVIL, MOTRIN IB
  • TYLENOL