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Altitude Diseases

by John B. West, MD, PhD, DSc

Altitude diseases occur because of a lack of oxygen at high altitudes.

  • Symptoms include headache, tiredness, irritability, and in more serious cases, shortness of breath, confusion, and even coma.

  • Doctors diagnose altitude diseases primarily based on the symptoms.

  • Treatment includes rest, descending to a lower altitude, and sometimes drugs, extra oxygen, or both.

  • People may prevent these disorders by ascending slowly and sometimes by taking drugs.

As altitude increases, the atmospheric pressure decreases, thinning the air so that less oxygen is available. For example, compared with the air at sea level, the air at 19,000 feet (5,800 meters) contains only half the amount of oxygen. In Denver, which is located about 5,300 feet (1,615 meters) above sea level, the air contains 20% less oxygen.

Most people can ascend to 5,000 to 6,500 feet (1,500 to 2,000 meters) in one day without problems, but about 20% of people who ascend to 8,000 feet (2,500 meters) and 40% who ascend to 10,000 feet (3,000 meters) develop some form of altitude disease.

The organs most commonly affected by altitude diseases are the

  • Brain (causing acute mountain sickness and rarely high-altitude cerebral edema)

  • Lungs (causing high-altitude pulmonary edema)

In the lungs, there is elevated pressure in some of the smaller blood vessels, including the smallest ones (capillaries). The capillaries also may leak fluid.

Risk factors

Effects of high altitude vary greatly among individuals. But generally, risk is increased by

  • Going too high too fast

  • Undertaking too much exertion

Risk is greater in people who previously had an altitude disease and in those who normally live at sea level or at very low altitude (below 3,000 feet [900 meters]). Young children and young adults also are probably more susceptible.

People who have disorders such as diabetes, coronary artery disease, and mild chronic obstructive pulmonary disease are not at increased risk for altitude diseases. However, such people may have particular difficulties at high altitude because of the low oxygen levels (hypoxia). Physical fitness is not protective. Asthma does not generally seem to be worse at high altitudes. Also, spending less than a few weeks at higher altitudes (but below 10,000 feet) does not appear to be dangerous for a pregnant woman or the fetus.


The body eventually adjusts (acclimatizes) to higher altitudes by increasing respiration and heart activity and by producing more red blood cells to carry oxygen to the tissues. Most people can adjust to altitudes of up to 10,000 feet in a few days. Adjusting to much higher altitudes takes many days or weeks, but some people can eventually carry out nearly normal activities at altitudes above 17,500 feet (about 5,300 meters). However, no one can fully acclimatize to long-term residence above that altitude.

Did You Know...

  • Symptoms of acute mountain sickness may be mistaken for a hangover, physical exhaustion, a migraine, or a viral illness.


Acute mountain sickness

Acute mountain sickness is a mild form of altitude disease and is the most common form. It may develop at altitudes as low as 6,500 feet (2,000 meters). Symptoms usually develop within 6 to 10 hours of ascent and often include headache and one or more other symptoms, such as light-headedness, loss of appetite, nausea, vomiting, fatigue, weakness, irritability, or trouble sleeping. Some people describe the symptoms as similar to those of a hangover. Symptoms usually last 24 to 48 hours. Occasionally, acute mountain sickness progresses to more severe forms of altitude disease.

High-altitude pulmonary edema (HAPE)

HAPE usually develops 24 to 96 hours after a rapid ascent to over 8,000 feet (2,500 meters). HAPE is responsible for most deaths due to altitude disease. HAPE is more common among young men. People who live at high altitudes may develop HAPE when they return after a brief stay at a lower altitude. Respiratory infections, even minor ones, appear to increase the risk. Symptoms are worse at night and can quickly become more severe. Mild symptoms usually include a dry cough and shortness of breath after only mild exertion. Moderate symptoms include shortness of breath at rest, confusion, pink or bloody sputum, low-grade fever (less than about 101° F), and a bluish tinge to the skin, lips, and nails (cyanosis). Severe symptoms include gasping for breath and making gurgling sounds while breathing.

High-altitude cerebral edema (HACE)

HACE is a rare but potentially fatal condition. People with HACE have headache, confusion, walking that is unsteady and uncoordinated (ataxia), and coma. These symptoms may progress rapidly from mild to life-threatening within a few hours.

Other symptoms

Swelling of the hands, the feet, and, on awakening, the face is common. The swelling causes little discomfort and usually goes away in a few days.

Some people have only a headache without any other symptoms of acute mountain sickness.

Retinal hemorrhages (small areas of bleeding in the retina at the back of the eye) may develop after ascent to altitudes of 9,000 feet (2,700 meters). These hemorrhages are common above 16,000 feet (5,000 meters). People usually have no symptoms unless the hemorrhage occurs in the part of the eye that is responsible for central vision (the macula). In such cases, people may notice a small blind spot. Retinal hemorrhages resolve rapidly without causing long-term problems.


Doctors diagnose altitude diseases based mainly on the symptoms. In people with HAPE, doctors can usually hear fluid in the lungs through a stethoscope. An x-ray of the chest and measurement of the amount of oxygen in the blood can help confirm the diagnosis.


Rate of ascent

The best way to prevent altitude disease is to ascend slowly. The altitude at which a person sleeps is more important than the maximum height reached during the day. On the first night, people should not sleep any higher than 8,000 to 10,000 feet (2,500 to 3,000 meters). Mountain climbers should sleep at that altitude for 2 to 3 nights before they sleep at any higher altitudes. Each day thereafter, sleeping altitude can be increased by about 1,000 feet (300 meters), although higher day hikes are acceptable as long as people return to the lower level for sleep.

People vary in their ability to ascend without developing symptoms. Thus, a climbing party should be paced for its slowest member. The pace of ascent should be slowed if symptoms of altitude disease develop.

Acclimatization reverses quickly. If acclimatized people have descended to low levels for more than a few days, they must once more follow a graded ascent.


Acetazolamide taken at the start of the ascent can reduce the likelihood of altitude diseases. If taken after the disease has begun, acetazolamide may help lessen symptoms. Acetazolamide should be continued for a few days after ascent. Some doctors believe that dexamethasone can also reduce the likelihood of altitude disease and lessen its symptoms.

Taking analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs—see Nonopioid Analgesics : Nonsteroidal Anti-Inflammatory Drugs) may help prevent high-altitude headache.

Using low-flow oxygen during sleep may also be helpful, but this measure may be difficult to carry out.

People who have had previous episodes of HAPE should be alert for any symptoms of a recurrence and descend immediately if symptoms occur. Some doctors also recommend such people take the drug nifedipine by mouth or inhaled bronchodilators for prevention of HAPE.

General measures

Avoiding strenuous exertion for a day or two after arrival may help prevent altitude diseases, as may eating frequent, small meals that are high in easily digested carbohydrates (such as fruits, jams, and starches) instead of fewer large meals. People should drink plenty of noncaffeinated fluids. Alcohol and sedatives, which can increase the risk of developing acute mountain sickness and cause symptoms similar to it, should be avoided.

Although physical fitness enables greater exertion at altitude, it does not protect against any form of altitude disease.


People who have swelling of the hands, feet, and face do not need treatment. The swelling goes away on its own after a few days.

People with acute mountain sickness must stop their ascent and rest. They should not ascend to higher altitudes until symptoms disappear. Most people with acute mountain sickness improve within a day or two. Acetazolamide may help relieve symptoms. Acetaminophen or NSAIDs help relieve headache.

If symptoms are more severe, supplemental oxygen should be provided through a face mask. If supplemental oxygen is unavailable, or if symptoms persist or worsen despite treatment, the person should descend to a lower altitude, preferably 1,650 to 3,200 feet (500 to 1,000 meters) lower.

People with HAPE should descend to a low altitude as soon as possible. Oxygen should be given if it is available. The drug nifedipine may temporarily help by decreasing blood pressure in the arteries to the lungs.

If HACE develops, the person should descend as far down and as soon as possible. Oxygen and dexamethasone should be taken.

When prompt descent to a lower altitude is not possible and people are seriously ill, a hyperbaric bag can be used to buy time. This device consists of a lightweight, portable fabric bag large enough to completely contain a person and a manually operated pump. The person is sealed tightly in the bag, and the bag's internal pressure is then increased using the pump. The increased air pressure simulates a decrease in altitude. The person remains in the bag for 2 or 3 hours. The hyperbaric bag is as beneficial as supplemental oxygen, which often is not available when mountain climbing, but is not a substitute for descent.

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