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Overview of Sprains and Other Soft-Tissue Injuries

By

Danielle Campagne

, MD, University of California, San Francisco

Reviewed/Revised Jul 2023
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Sprains are tears in ligaments (tissues that connect one bone to another). Other soft-tissue injuries include tears in muscles (strains) and tears (ruptures) in tendons (tissues that connect muscles to bones).

  • Most injuries to muscles and the tissues that connect them result from injuries or overuse.

  • The injured part hurts (especially when it is used), is usually swollen, and may be bruised.

  • Other injuries, such as fractures, dislocations, blood vessel and nerve damage, compartment syndrome, infections, and long-lasting joint problems, may also be present or develop.

  • Doctors can sometimes diagnose these problems based on symptoms, the circumstances causing the injury, and results of a physical examination, but sometimes x-rays or other imaging tests are needed.

  • Most injuries heal well and result in few problems, but how long they take to heal varies, depending on many factors, such as the person's age, the type and severity of the injury, and other disorders present.

  • Treatment depends on the type and severity of the injury and may include pain relievers, PRICE (protection, rest, ice, compression, and elevation), immobilization of the injured part (for example, with a cast or splint), and sometimes surgery.

Bones, muscles, and the tissues that connect them (ligaments, tendons, and other connective tissue, which are called soft tissues) make up the musculoskeletal system. These structures give the body its form, make it stable, and enable it to move.

Tissues of the musculoskeletal system can be damaged in various ways:

Sprains, strains, and other musculoskeletal injuries vary greatly in severity and in the treatment needed.

Sprains and strains can be

  • Mild (1st-degree): Fibers in muscles or ligaments are stretched but not torn, or only a few fibers are torn.

  • Moderate (2nd-degree): Some to almost all fibers are torn.

  • Severe (3rd-degree): All fibers are torn.

Tendons may also be completely or partially torn. If a tendon is completely torn, the affected body part usually cannot move. If only part of the tendon is torn, movement is unaffected, but the tendon may continue to tear and may later tear completely, particularly if people put substantial pressure on the affected part.

Many partial tears in ligaments, tendons, or muscles heal spontaneously.

Complete tears often require surgery.

Muscles and other soft tissues may be seriously damaged when a bone is fractured or dislocated. The skin, nerves, blood vessels, and organs may also be damaged. These injuries can cause temporary or permanent problems.

Causes of Sprains and Other Soft-Tissue Injuries

Trauma is the most common cause of soft-tissue and other musculoskeletal injuries.

Trauma includes

  • Direct force, as occurs in falls or motor vehicle accidents or during some sports, such as football

  • Repeated wear and tear, as occurs during daily activities or results from vibration or jerking movements

  • Overuse, as may occur when athletes overtrain

How severe an injury is depends partly on how strong the force is.

Sprains and strains are common sports injuries Sports Injuries . For example, they can occur during running, especially when people suddenly change direction, or during strength training—for example, when weight lifters quickly drop or yank the load rather than moving slowly and smoothly.

Symptoms of Sprains and Other Soft-Tissue Injuries

The most obvious symptom of soft-tissue injuries is

  • Pain

The injured part hurts, especially when people try to put weight on it or use it. The area around the injury is tender to the touch. Other symptoms include

  • Swelling

  • Bruising or discoloration

  • Muscle spasms (unintended contraction of muscles)

  • Inability to use the injured part normally

  • Possibly loss of feeling (numbness or abnormal sensations)

  • A part that looks distorted, bent, or out of place (which suggests that a fracture or a dislocation has also occurred)

The injured part (such as an arm, a leg, a hand, a finger, or a toe) often cannot be moved normally because movement is painful and/or a structure (muscle, tendon, or ligament) is damaged.

Swelling may take several hours to develop. If no swelling occurs within this time, a severe sprain is unlikely.

Bruises appear when bleeding occurs under the skin. The blood comes from broken blood vessels in the injured tissues. At first, the bruise is purplish black, then slowly turns green and yellow as the blood is broken down and reabsorbed back into the body. The blood can move quite a distance from the injury, causing a large bruise or a bruise some distance from the injury. For example, a bruise on the forehead can cause a bruise to later appear under the eyes. It can take a few weeks for blood to be reabsorbed. The blood can cause temporary pain and stiffness in the surrounding structures.

Because moving the injured part is so painful, some people are unwilling or unable to move it. If people (such as young children or older people) cannot speak, refusal to move a body part may be the only sign of an injury. However, some injuries do not keep people from moving the injured part. Being able to move an injured part does not mean that there is no injury.

Complications of Sprains and Other Soft-Tissue Injuries

Soft-tissue injuries can be accompanied by or lead to other problems (complications). For example, the injured limb may no longer be able to function normally. However, serious complications are uncommon. The risk of serious complications is increased if the skin is torn or if blood vessels or nerves are damaged.

Some complications (such as blood vessel and nerve damage) occur during the first hours or days after the injury. Others (such as problems with healing Rehabilitation and Prognosis Rehabilitation and Prognosis and with joints) develop over time.

Bleeding

Significant soft-tissue injuries cause bleeding under the skin (bruises).

If a person is taking a medication to prevent blood clots from forming (an anticoagulant), relatively minor injuries can cause substantial bleeding.

Blood vessel damage

Rarely, what appears to be a severe sprain (for example, of the knee) may be a dislocation that has slipped back in place on its own. These dislocations may damage an artery and disrupt the blood supply to the injured limb. A disrupted blood supply may not cause any symptoms until several hours after the injury. Untreated, such damage can lead to loss of the limb.

Nerve damage

Sometimes nerves are stretched, bruised, crushed, or torn. A direct blow can bruise or crush a nerve. Crushing causes more damage than bruising. Nerve damage causes numbness and sometimes tingling in the area past where the nerve is damaged. These injuries usually heal on their own over weeks to months to years, depending on the severity of the injury. Torn nerves do not heal spontaneously and may have to be repaired surgically. Some nerve injuries never heal completely.

Joint problems

Joints can become stiff if they must be kept from moving (immobilized) for a long time—for example, by a splint or cast. The knee, elbow, and shoulder are particularly likely to become stiff after an injury, especially in older people.

Physical therapy is usually needed to prevent stiffness and help the joint move as normally as possible.

Severe sprains can make a joint unstable. Having unstable joints can be disabling and increases the risk of osteoarthritis Osteoarthritis (OA) Osteoarthritis is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Arthritis due to damage of joint... read more Osteoarthritis (OA) . Appropriate treatment can help prevent permanent problems.

Compartment syndrome

Rarely, swelling (usually under a cast) is severe enough to contribute to compartment syndrome Compartment Syndrome Compartment syndrome is increased pressure in the space around certain muscles. It occurs when injured muscles swell so much that they cut off their blood supply. Pain in the injured limb increases... read more . Because the swelling puts pressure on nearby blood vessels, blood flow to the injured limb is reduced or blocked. As a result, tissues in the limb may be damaged or die, and the limb may have to be amputated.

Diagnosis of Sprains and Other Soft-Tissue Injuries

  • A doctor's evaluation

  • X-rays if needed to check for fractures

  • Sometimes magnetic resonance imaging or computed tomography

To diagnose sprains, strains, and tendon injuries, doctors ask detailed questions about the injury and do a thorough physical examination. They can often diagnose soft-tissue injuries based on this information and the results of the physical examination.

If a musculoskeletal problem occurs suddenly, people must decide whether to go to an emergency department, call their doctor, or wait and see whether the problem (pain, swelling, or other symptoms) goes away and lessens on its own.

People should be taken to an emergency department, often by ambulance, if any of the following apply:

  • The problem is obviously serious (for example, if it resulted from a car crash or if people cannot use the injured body part).

  • They suspect that they have a fracture (a possible exception is a toe or fingertip injury).

  • They suspect they have a severe dislocation or soft-tissue injury (such as a torn tendon or severe sprain or strain).

  • They have several injuries.

  • They have symptoms of a complication—for example, if they lose sensation in the affected body part, they cannot move the affected part normally, the skin feels cool or turns blue, or the injured part is weak.

  • They cannot put any weight on the affected body part.

  • An injured joint feels unstable.

People should call a doctor when

  • The injury causes pain or swelling, but they do not think the injured part is fractured or severely injured.

If none of the above apply and the injury seems minor, people can call the doctor or wait and see whether the problem goes away on its own.

If injuries result from a serious accident, the doctor's first priority is

For example, doctors check for numbness, measure blood pressure (which is low in people who have lost a lot of blood), check pulses (which are absent or weak when blood flow is disrupted), and look for other signs of disrupted blood flow, such as skin that is pale and cool. If any of these injuries and complications are present, doctors treat them as needed, then continue with the evaluation.

People should be checked for fractures and dislocations as well as ligament, tendon, and muscle injuries. Sometimes doctors must first make sure that there are no fractures before they do parts of this evaluation.

Description of the injury

Doctors ask the person (or a witness) to describe what happened. The person may not remember how an injury occurred or cannot describe it accurately. Knowing how the injury occurred can help doctors determine the type of injury. For example, if a person reports that a snap or pop occurred, the cause may be an injury to a ligament or tendon (or a fracture). Also, doctors ask in which direction the joint was stressed during the injury. This information can help doctors determine which ligaments and/or bones may be damaged.

Doctors also ask when the pain started. If it started immediately after the injury, the cause may be a severe sprain. If the pain began hours to days later, the injury is usually minor. If the pain is more severe than expected for the injury or if the pain steadily worsens during the first hours after the injury, compartment syndrome may have developed or blood flow may be disrupted.

The person is also asked about past injuries and use of medications that can increase the risk of tendon tears (including corticosteroids and fluoroquinolone antibiotics such as ciprofloxacin).

Physical examination

The physical examination includes the following (in order of priority):

  • Checking for damage to blood vessels near the injured body part

  • Checking for damage to nerves near the injured part

  • Examining and moving the injured part

  • Examining the joints above and below the injured part

To check for signs of blood vessel damage and disrupted blood flow, doctors check pulses and skin color and temperature. When blood flow is disrupted (as can occur in compartment syndrome), pulses may be absent or weak and the skin may be pale and cool. Doctors measure blood pressure, which is usually low in people who have lost a lot of blood.

To check for nerve damage, doctors evaluate sensation in the skin—whether the person can feel normally—and ask whether the person has abnormal sensations, such as a pins-and-needles sensation, tingling, or numbness. Abnormal sensations suggest that nerves have been damaged.

Doctors gently feel the injured part to determine whether the area is tender and whether tendons or muscles feel abnormal. If a fracture or dislocation is present, doctors may feel that bones are in pieces or out of place. Doctors also check for swelling and bruising. They ask whether the person can use, put weight on, and move the injured part.

Doctors test the stability of a joint by gently moving it in a way that puts stress on the joint (called stress testing). If the joint feels very unstable, doctors suspect a severe ligament injury (or a dislocation). However, if a fracture is possible, x-rays are done first to determine whether moving the joint is safe. Sometimes, stress testing is delayed until pain lessens.

Moving the affected joint can also help doctors determine the severity of an injury. For example, they can determine how severe a sprain (a torn ligament) is based on how far they can move the joint and how painful the movement is. When a ligament is partially torn, moving the joint is very painful. When a ligament is completely torn, moving the joint is less painful because the torn ligament is not being stretched as the joint is moved. A joint can usually be moved more freely when a ligament is torn than when it is not and can be moved more freely when a ligament is completely torn than when it is partially torn.

Because tendons connect muscles to bone, doctors can often determine the severity of a tendon injury by moving the muscle that the tendon is attached to. When a tendon is completely torn, moving the muscle attached to the tendon may not move the bone. For example, if the Achilles tendon (which attaches the calf muscles to the heel bone) is completely torn, the foot may not move. Partial tears may be hard to detect because the joint may seem to move normally.

If the physical examination does not detect a problem in the joint identified as painful, the injury may be elsewhere. This type of pain is called referred pain Pain pathways . For example, if the joint between the breastbone and collar bone is injured, people may feel pain in their shoulder. Thus, doctors always examine the joint above and below the painful joint to check for injury.

If pain or muscle spasms interfere with the examination, doctors may give the person a pain reliever and/or muscle relaxant by mouth or injection, or a local anesthetic may be injected into the injured area to make the examination easier. Or the injured part may be immobilized until the spasms stop, usually for a few days, and then examined.

Tests

Imaging tests are done to check for possible fractures and dislocations and to identify soft-tissue injuries. These tests include

  • X-rays if needed

  • Magnetic resonance imaging (MRI)

  • Sometimes computed tomography (CT)

X-rays are not always needed. They do not show injuries to ligaments, tendons, or muscles. They show only bones (and the fluid that collects around an injured joint). However, x-rays may be done to check for fractures and dislocations, which may also be present. In addition, x-rays can show abnormalities in the position of bones that may suggest a sprain or other soft-tissue injury.

X-rays, if needed, are usually taken from at least two angles. If a fracture is present, two x-rays can show how the fragments of bone are aligned.

MRI can show soft tissues, which are not usually visible on x-rays. MRI thus helps detect injury to tendons, ligaments, cartilage, and muscle.

CT or MRI may be done to check for subtle fractures, which may accompany a soft-tissue injury.

Did You Know...

  • X-rays show only bones and thus usually cannot help doctors identify injuries such as sprains, strains, and tendon injuries, even severe ones.

Other tests may be done to check for injuries that can accompany a soft-tissue injury:

Treatment of Sprains and Other Soft-Tissue Injuries

  • Treatment of any serious injuries or complications

  • Pain relief

  • Protection, rest, ice, compression, and elevation (PRICE)

  • Immobilization, usually with a splint or cast

  • Sometimes surgery

If people think that they have a severe injury, they should go to an emergency department. If they cannot walk or have several injuries, they should go by ambulance. Until they can get medical help, they should do the following:

  • Prevent the injured limb from moving (immobilize it) and support it with a makeshift splint, sling, or a pillow

  • Elevate the limb, above the level of the heart if possible, to limit swelling

  • Apply ice (wrapped in a towel or cloth) to control pain and swelling

Treatment of serious injuries

In the emergency department, doctors check for any injuries that require immediate treatment or may cause serious complications, such as compartment syndrome Compartment Syndrome Compartment syndrome is increased pressure in the space around certain muscles. It occurs when injured muscles swell so much that they cut off their blood supply. Pain in the injured limb increases... read more . Without treatment, complications may get worse, becoming more painful and making loss of function more likely.

To make sure the injured part is not deprived of blood, doctors surgically repair damaged arteries unless the arteries are small and blood flow is not affected.

Severed nerves are also repaired surgically, but this surgery can be delayed until several days after the injury if necessary. If nerves are bruised or damaged, they may heal on their own.

If the skin is torn, the wound is covered with a sterile dressing, and the injured person is given a vaccine to prevent tetanus Diphtheria-Tetanus-Pertussis Vaccine The diphtheria, tetanus, and pertussis vaccine is a combination vaccine that protects against these three diseases: Diphtheria usually causes inflammation of the throat and mucous membranes... read more and antibiotics to help prevent infection. Also, the wound is cleansed, usually after a local anesthetic is used to numb the area.

After serious injuries are treated, doctors focus on relieving symptoms and immobilizing soft-tissue injuries as needed.

Pain relief

PRICE

PRICE refers to the combination of protection, rest, ice, compression (pressure), and elevation. This treatment is used to treat injured muscles, ligaments, and tendons.

Protection helps prevent further injury that could worsen the original one. Typically, a splint or other device is applied.

Rest prevents further injury and may speed healing. People should limit their activity and avoid putting weight on and/or using the injured body part. For example, they should not participate in contact sports, and they should use crutches if needed.

Ice and compression minimize swelling and pain. Ice is enclosed in a plastic bag, towel, or cloth and applied for 15 to 20 minutes at a time, as often as possible during the first 24 to 48 hours. Usually, compression is applied to the injury with an elastic bandage.

Elevating the injured limb helps drain fluid away from the injury and thus reduce swelling. The injured limb is elevated above heart level for the first 2 days.

After 48 hours, people can periodically apply heat (for example, with a heating pad) for 15 to 20 minutes at a time. Heat may relieve pain and speed healing. However, whether heat or ice is best is unclear, and what works best may vary from one person to another.

How To Fit and Use Crutches

Immobilization

Keeping a limb from moving (immobilization) reduces pain and helps with healing by preventing further injury to surrounding tissues. Joints on both sides of the injury are immobilized.

If immobilization lasts too long (for example, for more than a few weeks in young adults), the joint may become stiff, sometimes permanently, and muscles may shorten (causing contractures) or shrink (waste away, or atrophy). Blood clots may develop. Such problems can develop quickly, and contractures can become permanent, usually in older people. Consequently, doctors encourage movement as soon as the injury heals. They also tend to use treatments that enable older people to walk as soon as possible, rather than ones that require them to be immobilized for a long time (such as bed rest or a cast).

Whether immobilization is required and which technique is used depend on the type of injury.

If a partial tear in a tendon is suspected or if the diagnosis is uncertain, doctors may apply a splint to immobilize the injured part so that the tendon can heal. Some severe tendon tears are immobilized for days or weeks, sometimes with a cast.

Mild sprains are immobilized briefly if at all. Moving the injured part as soon as possible is usually the best treatment. Moderate sprains are often immobilized with a sling or splint for a few days. Some severe sprains and tendon tears are immobilized for days or weeks, sometimes with a cast. However, many severe sprains must be surgically repaired and are not always immobilized.

Casts are usually used for injuries that must be kept immobilized for weeks.

To apply a cast, doctors wrap the injured part in cloth, then apply a layer of soft cottony material to protect the skin from pressure and rubbing. Over this padding, doctors wrap dampened plaster-filled cotton bandages or fiberglass strips, which harden when they dry. Plaster is often used to immobilize broken bones that have been separated because it molds well and is less likely to rub against the body. Fiberglass casts are stronger, lighter, and longer-lasting. After a week or so, the swelling goes down. Then, the plaster cast can sometimes be replaced with a fiberglass cast to fit the limb more snugly.

People who require a cast are given special instructions for its care. If a cast is not correctly cared for, problems can develop. For example, if the cast becomes wet, the protective padding under the cast may become wet, and drying it completely may be impossible. As a result, the skin can soften and break down, and sores may form. Also, if a plaster cast gets wet, it can fall apart and thus no longer protect and immobilize the injured area.

People are instructed to keep the cast elevated as much as possible at or above heart level, especially for the first 24 to 48 hours. Ideally, elevation is in a position that provides an uninterrupted downward path, allowing gravity to help drain swelling. People should also regularly flex and extend their fingers or wiggle their toes.

Taking Care of a Cast

  • When bathing, enclose the cast in a plastic bag and carefully seal the top with rubber bands or tape or use a waterproof cover designed to cover a cast. Such covers are commercially available, convenient to use, and more reliable. If a cast becomes wet, the padding under the cast may retain moisture. A hair dryer can remove some dampness. Otherwise, the cast must be changed to prevent skin from breaking down.

  • Never put an object inside the cast (for example, to scratch an itch).

  • Check the skin around the cast every day, and report any red or sore area to a doctor.

  • Check the edges of the cast everyday, and if they feel rough, place soft adhesive tape, tissues, cloth, or another soft material to pad them and keep them from injuring the skin.

  • When resting, position the cast carefully, possibly using a small pillow or pad, to prevent the cast's edge from pinching or digging into the skin.

  • Elevate the cast regularly, as directed by the doctor, to control swelling.

  • Contact a doctor immediately if the cast causes persistent pain or feels excessively tight. These symptoms may result from pressure sores or swelling, which may require immediate removal of the cast.

  • Contact a doctor if the cast gives off an odor or if a fever develops. These symptoms may indicate an infection.

  • Contact a doctor if the cast causes worsening pain or numbness or weakness. These symptoms may indicate compartment syndrome.

A splint can be used to immobilize some sprains and other injuries, particularly if they need to be kept immobile for only a few days or less. Splints allow people to apply ice and to move more than a cast does.

A splint is a long, narrow slab of plaster, fiberglass, or aluminum applied with elastic wrap or tape. Because the slab does not completely encircle the limb, there is room for some expansion due to swelling. Thus, a splint does not increase the risk of developing compartment syndrome. Some injuries that eventually require a cast are first immobilized with a splint until most of the swelling resolves.

A sling by itself can provide some support. Slings can be useful when complete immobilization has undesirable effects. For example, if a shoulder is completely immobilized, the tissues around the joint may become stiff, sometimes within days, preventing the shoulder from moving (called frozen shoulder). Slings limit movement of the shoulder and elbow but allow movement of the hand.

A swathe, which is a piece of cloth or a strap, may be used with a sling to prevent the arm from swinging outward, especially at night. The swathe is wrapped around the person's back and over the injured part.

Commonly Used Techniques for Immobilizing a Joint

Commonly Used Techniques for Immobilizing a Joint

Surgery

Many 3rd-degree sprains and tendon tears require surgical repair.

Arthroscopic surgery Surgery Through a Keyhole Surgery Through a Keyhole is sometimes used. For this procedure, a pencil-sized viewing tube is inserted in the joint through a tiny incision. This procedure is done most often to repair ligaments in the knee (knee sprains Knee Sprains and Related Injuries Knee sprains occur when the ligaments that attach the thighbone (femur) to the shinbone (tibia) are torn. The cartilage pads (menisci), which act as shock absorbers in the knee, may also be... read more Knee Sprains and Related Injuries ) or pads of cartilage (menisci) in the knee.

Rehabilitation and Prognosis for Soft-Tissue Injuries

Most soft-tissue injuries heal well and result in few problems. However, some do not completely heal even though they are diagnosed and treated appropriately.

How long an injury takes to heal varies from weeks to months depending on

  • Type of injury

  • Location of the injury

  • The person's age

  • Other disorders present

Being immobilized makes joints stiff, and muscles weaken and shrink because they are not used. If a limb is immobilized in a cast, the affected joint becomes stiffer each week, and eventually people become unable to fully extend and flex their limb. Such problems can develop quickly and become permanent, usually in older people. After wearing a long leg cast (upper thigh to the toes) for a few weeks, the muscles usually shrink so much that people can insert their hand into the formerly tight space between the cast and their thigh. When the cast is removed, their muscles are very weak and look noticeably smaller.

After the injury has healed sufficiently and the joint is no longer immobilized, people can start exercising the injured limb. When exercising, they should pay attention to how the injured limb feels and avoid exercising too forcefully. If the muscles are too weak for people to exercise them, a therapist moves their limbs for them (called passive exercise Increasing the Shoulder's Range of Motion Increasing the Shoulder's Range of Motion ). However, ultimately, to regain full strength of an injured limb, people must move their own muscles (called active exercise).

Exercises to improve range of motion and muscle strength and to strengthen and stabilize the injured joint can help prevent injuries from recurring and help prevent long-term impairment.

Most people feel some discomfort during activities, even after injuries have healed enough to allow them to put their full weight on the injured part.

Spotlight on Aging: Soft-Tissue Injuries

Adults over 65 are more likely to injure muscles ligaments, and tendons, partly because they are more likely to fall. They are more likely to fall for the following reasons:

In older people, recovery is often more complicated and slower than it is in younger people because

  • Older adults usually heal more slowly than younger adults.

  • Older people typically have less overall strength, less flexibility, and poorer balance than younger people. Thus, compensating for the limitations caused by an injury is harder, and returning to daily activities is more difficult.

  • When older people are inactive or immobilized (by casts or splints), they lose muscle tissue more quickly than younger adults, Thus, immobilization can lead to muscle weakness. Sometimes muscles become permanently shorter, and scar tissue forms in tissues around the joint such as ligaments and tendons. This condition (called joint contractures) limits movement of the joint.

  • Older people are more likely to have other disorders (such as arthritis or poor circulation), which can interfere with recovery or slow healing.

Even minor injuries can greatly interfere with older adults' ability to do normal daily activities, such as eating, dressing, bathing, and even walking, especially if they used a walker before the injury.

Immobilization: Being immobilized is a particular problem in older adults.

In older adults, being immobilized is more likely to cause the following:

Pressure sores develop when blood flow to an area is cut off or greatly reduced. In older adults, blood flow to a limb may already be reduced. When the weight of an injured limb rests on a cast, blood flow is reduced even more, and pressure sores may form. If bed rest is required, pressure sores can develop on areas of skin that touch the bed. These areas should be diligently inspected for any sign that the skin is breaking down.

Because immobilization is more likely to cause problems in older adults, treatment of musculoskeletal injuries focuses on helping older adults return to daily activities as quickly as possible.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Cetraxal , Ciloxan, Cipro, Cipro XR, OTIPRIO, Proquin XR
7T Gummy ES, Acephen, Aceta, Actamin, Adult Pain Relief, Anacin Aspirin Free, Aphen, Apra, Children's Acetaminophen, Children's Pain & Fever , Children's Pain Relief, Comtrex Sore Throat Relief, ED-APAP, ElixSure Fever/Pain, Feverall, Genapap, Genebs, Goody's Back & Body Pain, Infantaire, Infants' Acetaminophen, LIQUID PAIN RELIEF, Little Fevers, Little Remedies Infant Fever + Pain Reliever, Mapap, Mapap Arthritis Pain, Mapap Infants, Mapap Junior, M-PAP, Nortemp, Ofirmev, Pain & Fever , Pain and Fever , PAIN RELIEF , PAIN RELIEF Extra Strength, Panadol, PediaCare Children's Fever Reducer/Pain Reliever, PediaCare Children's Smooth Metls Fever Reducer/Pain Reliever, PediaCare Infant's Fever Reducer/Pain Reliever, Pediaphen, PHARBETOL, Plus PHARMA, Q-Pap, Q-Pap Extra Strength, Silapap, Triaminic Fever Reducer and Pain Reliever, Triaminic Infant Fever Reducer and Pain Reliever, Tylenol, Tylenol 8 Hour, Tylenol 8 Hour Arthritis Pain, Tylenol 8 Hour Muscle Aches & Pain, Tylenol Arthritis Pain, Tylenol Children's, Tylenol Children's Pain+Fever, Tylenol CrushableTablet, Tylenol Extra Strength, Tylenol Infants', Tylenol Infants Pain + Fever, Tylenol Junior Strength, Tylenol Pain + Fever, Tylenol Regular Strength, Tylenol Sore Throat, XS No Aspirin, XS Pain Reliever
Anacin Adult Low Strength, Aspergum, Aspir-Low, Aspirtab , Aspir-Trin , Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength, Bayer Aspirin Plus, Bayer Aspirin Regimen, Bayer Children's Aspirin, Bayer Extra Strength, Bayer Extra Strength Plus, Bayer Genuine Aspirin, Bayer Low Dose Aspirin Regimen, Bayer Womens Aspirin , BeneHealth Aspirin, Bufferin, Bufferin Extra Strength, Bufferin Low Dose, DURLAZA, Easprin , Ecotrin, Ecotrin Low Strength, Genacote, Halfprin, MiniPrin, St. Joseph Adult Low Strength, St. Joseph Aspirin, VAZALORE, Zero Order Release Aspirin, ZORprin
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