• Venomous snakes in the United States include pit vipers (rattlesnakes, copperheads, and cottonmouths) and coral snakes.
• Severe envenomation can cause damage to the bitten extremity, bleeding, and vital organ damage.
• Venom antidote is given for serious bites.

Bites from nonpoisonous snakes rarely produce any serious problems. About 25 species of venomous (poisonous) snakes are native to the United States. The venomous snakes include pit vipers (rattlesnakes, copperheads, and cottonmouths) and coral snakes. Of the roughly 45,000 snakebites that occur in the United States each year, fewer than 8,000 are from venomous snakes, and about six people die. Fatal snakebites are much more common outside the United States.

In about 25% of all pit viper bites, venom is not injected. Most deaths occur in children, older people, and people who are untreated or treated too late or inappropriately. Rattlesnakes account for about 70% of poisonous snakebites in the United States and for almost all of the deaths. Copperheads and, to a lesser extent, cottonmouths account for most other poisonous snakebites. Coral snake bites and bites from imported snakes are much less common.

The venom of rattlesnakes and other pit vipers damages tissue around the bite. Venom may produce changes in blood cells, prevent blood from clotting, and damage blood vessels, causing them to leak. These changes can lead to internal bleeding and to heart, respiratory, and kidney failure. The venom of coral snakes affects nervous system activity but causes little damage to tissue around the bite. Most bites occur on the hand or foot.

Did You Know... Snake bites can be terrifying but rarely cause deaths in the United States.

Symptoms

The symptoms of snake venom poisoning vary widely, depending on the following:

• The size and species of snake
• The amount and toxicity of the venom injected (related to the size and species of snake)
• The bite's location (the farther away from the head and trunk, the less dangerous)
• The person's age (very old and very young people are at higher risk)
• The person's underlying medical problems

Pit Vipers: Bites by most pit vipers rapidly cause pain. Redness and swelling usually follow within 20 to 30 minutes and can affect the entire leg or arm within several hours. People bitten by a rattlesnake may experience tingling and numbness in the fingers or toes or around the mouth and a metallic or rubbery taste in the mouth. Other symptoms include fever, chills, general weakness, faintness, sweating, anxiety, confusion, and nausea and vomiting. Some of these symptoms may be caused by terror rather than venom. Breathing difficulties can develop, particularly after Mojave rattlesnake bites. People may have a headache, blurred vision, drooping eyelids, and a dry mouth.

Rattlesnake Bite

Moderate or severe pit viper poisoning commonly causes bruising of the skin 3 to 6 hours after the bite. The skin around the bite appears tight and discolored. Blisters, often filled with blood, may form in the bite area. Without treatment, tissue around the bite may be destroyed. The gums may bleed, and blood may appear in the person's vomit, stools, and urine.

Coral Snakes: Coral snake bites usually cause little or no immediate pain and swelling. More severe symptoms may take several hours to develop. The area around the bite may tingle, and nearby muscles may become weak. Muscle incoordination and severe general weakness may follow. Other symptoms may include double vision, blurred vision, confusion, drowsiness, increased saliva production, and speech and swallowing difficulties. Breathing problems, which may be extreme, may develop.

Is That a Pit Viper? Pit vipers have certain features that can help distinguish them from nonvenomous snakes: Vertical slitlike pupils Pits between the eyes and nose Retractable fangs Rows of single scales across the underside of the tail Triangular heads (like an arrowhead) Nonvenomous snakes tend to have the following: Rounded heads Round pupils No pits No fangs Rows of double scales across the underside of the tail If people see a snake with no fangs, they should not assume it is nonvenomous because the fangs may be retracted.

Coral Snake

Diagnosis

Emergency medical personnel must try to determine whether the snake was poisonous, what species it was, and whether venom was injected. The bite marks sometimes suggest whether the snake was poisonous. The fangs of a poisonous snake usually produce one or two large punctures, whereas the teeth of nonpoisonous snakes usually leave multiple small rows of scratches. Without a detailed description of the snake, doctors may have difficulty determining the particular species that caused the bite. Envenomation is recognized by the development of characteristic symptoms. People who are bitten by a poisonous snake are generally kept in the hospital for observation for 6 to 8 hours to see if any symptoms develop. Doctors do various tests to assess the effects of the venom.

Treatment

First aid can be helpful before medical help arrives. People bitten by a poisonous snake should be moved beyond the snake's striking distance, kept as calm and still as possible, and taken to the nearest medical facility immediately. The bitten limb should be loosely immobilized and kept positioned just below heart level. Rings, watches, and tight clothing should be removed from the area of the bite. Alcohol and caffeine should be avoided. Tourniquets, ice packs, and cutting the bite open are not recommended because they are potentially harmful.

If no venom was injected, treatment is the same as for any puncture wound (see First Aid: Wounds).

Venom antidote (antivenom) is the most important part of treatment if venom was injected and symptoms indicate a serious bite. Antivenom is more effective the sooner it is given. Antivenom neutralizes venom's toxic effects. It is given intravenously and is available for all native poisonous snakes. Pit viper antivenom made from horse serum frequently causes serum sickness (an immune system reaction against foreign protein). Newer antivenom made of purified antibody fragments from sheep is less likely to cause serum sickness.

What Is Serum Sickness?
Serum sickness is a reaction by the immune system against large amounts of foreign protein that have entered the bloodstream. A common source of such foreign protein is horse serum, an ingredient present in many venom antidotes (antivenoms) that are used to treat poisonous snake and spider bites and scorpion stings. Symptoms of serum sickness include fever, rash, and joint pains. Rarely, kidney damage and death can occur. Doctors treat serum sickness with antihistamines, such as diphenhydramineSome Trade Names BENADRYL , and corticosteroids. Antivenoms that do not contain horse serum are unlikely to result in serum sickness.

Intensive care unit treatment is required for people with severe envenomation. People are monitored closely, and the complications of envenomation are treated. People with low blood pressure are given fluids intravenously. If problems with blood clotting develop, fresh frozen plasma, concentrated clotting factors (cryoprecipitate), or platelet transfusions are given.

Prognosis depends on the person's age and overall health and on the location and venom content of the bite. Almost everyone bitten by a poisonous snake survives if treated early with appropriate amounts of antivenom.

Last full review/revision February 2009 by Robert A. Barish, MD, MBA