Beryllium disease (sometimes called berylliosis) is a lung inflammation caused by inhaling dust or fumes that contain beryllium.
In the past, beryllium was commonly mined and extracted for use in the electronics and chemical industries and in the manufacture of fluorescent light bulbs. Today, it is used mainly in the aerospace industry and in beryllium–aluminum castings. Besides workers in these industries, a few people living near beryllium refineries also have developed beryllium disease.
Beryllium disease differs from other environmental lung diseases (see Overview of Environmental Lung Diseases) in that at low levels of exposure, lung problems seem to occur only in people who are sensitive to beryllium—about 2 to 6% of those who come in contact with it. The disease can occur in such people even with a relatively brief exposure to beryllium dust.
Beryllium disease may be
Acute beryllium disease is now rare. Acute beryllium disease develops suddenly, mainly as inflammation of the lungs. The lungs are stiff and function poorly.
Chronic beryllium disease is more common. Abnormal tissue forms in the lungs and the lymph nodes enlarge.
People with acute beryllium disease have an abrupt onset of coughing, difficulty in breathing, and weight loss. Acute beryllium disease also can affect the skin (causing rashes) and eyes (causing redness and irritation).
In chronic beryllium disease, coughing, difficulty breathing, weight loss, night sweats, and fatigue develop gradually, often 10 to more than 40 years after exposure. When detected early, beryllium disease may initially cause no symptoms.
The diagnosis is based on the person's history of exposure to beryllium and on results of a blood test, called the beryllium lymphocyte proliferation test (BeLPT), which tests for allergy to beryllium.
If the disease is at a more advanced stage, characteristic changes on a chest x-ray or computed tomography (CT) help doctors make the diagnosis. However, x-rays and CT scans of people with beryllium disease resemble those of people with another type of lung disease called sarcoidosis (see Sarcoidosis). Definitive diagnosis is made by doing a test in which a tube, called a bronchoscope, is inserted into the lungs to obtain pieces of lung tissue and cells to test for an allergic reaction to beryllium.
Acute beryllium disease may be severe. Most people recover in 7 to 10 days, with appropriate treatment. However, some people with severe acute disease die or develop chronic beryllium disease.
The course of the disease in people who develop symptoms years after exposure is completely different. People with chronic beryllium disease continue to have symptoms, which tend to progress. If the lungs are severely damaged, the heart may become strained, causing a type of heart failure (cor pulmonale—see Sidebar 1: Cor Pulmonale: A Type of Heart Failure Caused by Lung Disorders) and death.
Beryllium disease can be prevented by strictly limiting exposure to beryllium.
People with acute beryllium disease are given oxygen as needed and may need a mechanical ventilator to support breathing. Corticosteroid drugs are given.
In chronic beryllium disease, corticosteroids, such as oral prednisone, may be given. Some people need to take corticosteroids for the rest of their lives. In some people with very severe chronic beryllium disease, lung transplantation can be life saving. Other supportive measures, such as supplemental oxygen therapy, pulmonary rehabilitation, and drugs for treatment of right-sided heart failure, are used as needed.
Last full review/revision January 2015 by Lee S. Newman, MD, MA