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- Hair Loss (Alopecia)
- Warning signs
- When to see the doctor
- What the doctor does
- Hair transplantation
- Key Points
- Alopecia Areata
- Resources In This Article
- Drugs Mentioned In This Article
Hair Loss (Alopecia)
Hair loss, also called alopecia, can occur on any part of the body. Hair loss that occurs on the scalp is generally called baldness. Hair loss is often of great concern to people for cosmetic reasons, but it can also be a sign of a bodywide (systemic) disorder.
Hair grows in cycles. Each cycle consists of a long growing phase (anagen), a brief transitional phase (catagen), and a short resting phase (telogen). At the end of the resting phase, the hair falls out, and the cycle begins again as a new hair starts growing in the follicle. Normally, about 50 to 100 scalp hairs reach the end of resting phase each day and fall out. When many more than 100 hairs/day go into resting phase, hair loss (telogen effluvium) may occur. A disruption of the growing phase that causes loss of hairs is called anagen effluvium.
Doctors sometimes classify hair loss as focal (confined to one part of the scalp) or diffuse (widespread). Hair loss may also be classified by whether or not scarring exists.
The most common cause of hair loss is
Other common causes of hair loss are
Certain systemic disorders, such as those that cause high fever, systemic lupus erythematosus (lupus), hormonal disorders, and nutritional deficiencies
Drugs, particularly chemotherapy
Fungal infections, such as ringworm of the scalp (tinea capitis)
Physical stresses, such as a high fever, surgery, a major illness, sudden weight loss, or pregnancy (which can lead to a telogen effluvium)
Psychologic stresses, including habitual pulling out of normal hair (trichotillomania—see Hair-Pulling Disorder)
Traction alopecia (hair loss caused by continuous traction such as from braids, rollers, or ponytails)
Less common causes include primary hair shaft abnormalities (that is, the abnormality originates in the hair shaft), sarcoidosis, heavy metal poisoning, radiation therapy, and rare skin conditions.
This form of alopecia may eventually affect up to 80% of white men by the age of 70 (male-pattern hair loss) and about half of all women (female-pattern hair loss). The hormone dihydrotestosterone plays a major role, along with heredity. The hair loss can begin at any age during or after puberty, even during adolescence.
In men, hair loss usually begins at the temples or on the top of the head toward the back. Some men lose only some hair and have only a receding hairline or a small bald spot in the back. Other men, especially when hair loss begins at a young age, lose all of the hair on the top of the head but retain hair on the sides and back of the scalp. This pattern is called male-pattern hair loss.
In women, hair loss occurs on the top of the head and is usually a thinning of the hair rather than a complete loss of hair. The hairline typically stays intact. This pattern is called female-pattern hair loss.
In alopecia areata (see Alopecia Areata), round, irregular patches of hair are suddenly lost. This disorder is believed to be caused by a malfunction of the body's immune system that causes the body to attack its own tissues (called an autoimmune reaction).
In cutaneous lupus erythematosus, areas of hair may be lost. Hair loss may be permanent if the hair follicle is completely destroyed. Cutaneous lupus erythematosus can affect people who have or do not have systemic lupus erythematosus (lupus—see Systemic Lupus Erythematosus (SLE)), a disorder in which antibodies or cells produced by the body attack the body's own tissues (called an autoimmune disorder). Systemic lupus erythematosus affects various organs throughout the body. In cutaneous lupus erythematosus, hair tends to be lost in patches.
If women have excessive amounts of male hormones, they can develop masculine characteristics (called virilization), such as a deepened voice, acne, and hair in locations more typical of male hair growth, such as the face and trunk (hirsutism—see Hairiness). Virilization can also include hair loss in the typical male pattern. The most common cause of virilization is polycystic ovary syndrome. Rarely, a tumor can secrete male hormones, causing virilization, or virilization may develop in a female who is taking anabolic steroids to enhance athletic performance.
Drugs: Male-pattern or female-pattern baldness can occur when anabolic steroids are used. Chemotherapy drugs typically cause anagen effluvium. Other prescription drugs (for example, drugs used to treat high blood pressure, acne, thyroid disorders, seizures, or blood thinners) typically cause hair loss via telogen effluvium.
Nutritional disorders are a less common cause of hair loss. Symptoms vary according to the specific nutritional disorder:
Excess vitamin A: Rash, scaly chapped lips, painful swelling of the limbs, sluggishness, loss of appetite, and weight loss
Iron deficiency: Anemia, easy exhaustion, and a decreased ability to exercise
Zinc deficiency: Rash, diarrhea, underdeveloped genitals, frequent infections, loss of appetite, and poor wound healing
These stresses can lead to the habitual twisting, teasing, or pulling out of normal hair (trichotillomania—see Hair-Pulling Disorder). The habit is most common among children but may occur in adults. The hair pulling may not be noticed for a long time, confusing doctors and parents, who may mistakenly think that a disorder such as alopecia areata or a fungal infection is causing the hair loss.
This fungal infection (see Scalp Ringworm) is a common cause of patchy hair loss in children. The infection begins as a dry, scaly patch that gradually enlarges. Hairs may eventually break off, usually flush with the surface of the scalp, looking like black dots. Sometimes the hair breaks off above the surface of the scalp, leaving short stubs. Hair loss may be permanent, especially if the infection is left untreated.
People who have hair loss and signs of a bodywide disorder should see a doctor promptly. Women who have developed masculine characteristics should call their doctor to discuss how soon they should be seen. Other people should see a doctor when possible, but an appointment is not urgent unless other symptoms develop.
Doctors first ask questions about the person's symptoms and medical history and then do a physical examination. What doctors find during the history and physical examination often suggests a cause of the hair loss and the tests that may need to be done.
Doctors ask about the hair loss:
They note other symptoms such as itching and scaling. They ask about hair care, including whether braids, rollers, and hair dryers are used and whether the hair is routinely pulled or twisted.
Doctors ask whether the person has been recently exposed to drugs, toxins, or radiation or has experienced significant stress (such as that resulting from surgery, chronic illness, or fever or psychologic stress). The person is asked about other characteristics that may suggest a cause, including dramatic weight loss, dietary practices (including various restrictive diets), and obsessive-compulsive behavior. Current and recent drug use is reviewed. The person is asked whether any family member has had hair loss.
During the physical examination, doctors focus on the scalp, noting the distribution of hair loss, the presence and characteristics of any skin abnormalities, and the presence of any scarring. They measure the width of the part and check for abnormalities of hair shafts.
Doctors evaluate hair loss elsewhere on the body (such as the eyebrows, eyelashes, arms, and legs). They look for rashes that may be associated with certain types of alopecia and for signs of virilization in women such as a deepened voice, hirsutism, an enlarged clitoris (the smaller female organ that corresponds to the penis), and acne. They also examine the thyroid gland.
Some Causes and Features of Hair Loss
Testing is usually unnecessary if a cause is identified based on the doctor's examination. For example, male-pattern or female-pattern hair loss generally requires no testing. However, if hair loss occurs in a young man with no family history of hair loss, the doctor may question him about use of anabolic steroids and other drugs. Women who have significant hair loss and who have developed masculine characteristics are asked whether they use prescription or illegal drugs and undergo blood tests to measure levels of the hormones testosterone and dehydroepiandrosterone sulfate (DHEAS). If the doctor's examination detects signs of other hormonal abnormalities or other serious illness, blood tests to identify those disorders may be needed.
The pull test helps doctors evaluate hair loss. Doctors gently pull on a bunch of hairs (about 40) on at least 3 different areas of the scalp. Doctors then count the number of hairs that come out with each pull and examine them under a microscope to determine their phase of growth. If more than 4 to 6 hairs in the telogen phase come out with each pull, the pull test is positive, and the person most likely has telogen effluvium.
During the pluck test, doctors abruptly pull out about 50 individual hairs (“by the roots”). Doctors examine the roots and shafts of the plucked hairs under a microscope to assess the hair shaft and determine the phase of growth. These results help doctors tell whether the person has a telogen effluvium, a primary hair shaft abnormality, or some other problem.
Daily hair counts can be done to quantify hair loss when the pull test is negative and it is not clear whether hair loss is actually excessive. Hairs lost in the first morning combing or during washing are collected in clear plastic bags daily for 14 days. The number of hairs in each bag is then recorded. Loss of more than 100 hairs/day is abnormal except after shampooing, when up to 250 hairs may be lost. Hairs may be brought in by the person for examination under a microscope.
A biopsy of the scalp skin (see Biopsy) is done if the diagnosis is not clear after a doctor's examination and other tests. A biopsy helps determine whether hair follicles are normal and can help differentiate alopecia that causes scarring (by destroying the hair follicle) from alopecia that does not. If the hair follicles are abnormal, the biopsy may indicate possible causes.
Specific causes of hair loss are treated when possible. For example, antifungal drugs are used to treat scalp ringworm. Drugs that are causing hair loss are switched or stopped. Hormonal disorders can be treated with drugs or surgery, depending on the cause. Iron or zinc supplements can be given if these minerals are deficient. Cutaneous lupus and lichen planopilaris can usually be treated with corticosteroids or other drugs applied to the scalp or taken by mouth.
Traction alopecia is treated by eliminating physical traction or stress to the scalp.
Scalp ringworm is treated with antifungal drugs taken by mouth.
Trichotillomania is difficult to treat, but behavioral modification, clomipramine, or a selective serotonin reuptake inhibitor (such as fluoxetine, fluvoxamine, paroxetine, sertraline, escitalopram, or citalopram) may be useful.
Hair loss due to physical stresses such as recent weight loss, surgery, a severe illness with a fever, or delivery of a baby (telogen effluvium) is not typically treated because it tends to resolve on its own. Applying minoxidil to the scalp may be helpful for some people.
If hair does not regrow on its own, hair replacement methods can be tried, including
Male-pattern and female-pattern hair loss can sometimes be treated effectively with drugs.
Minoxidil may prevent further hair loss and increase hair growth when applied directly to the scalp twice a day. Hair regrowth can take 8 to 12 months and is noticeable in only about 30 to 40% of people. The most common side effects are skin irritation, such as itching and rash. An increase in hair on the face can also occur.
Finasteride works by blocking the effects of male hormones on the hair follicles and is taken by mouth daily. Finasteride is not used in women. In men, its effectiveness at stopping hair loss and stimulating hair growth is usually evident within 6 to 8 months of treatment and increases over time but can vary from person to person. Finasteride can decrease libido, increase breast size, and contribute to erectile dysfunction. Finasteride can also decrease prostate-specific antigen (PSA) levels. Men should discuss how finasteride can affect prostate cancer screening with their doctor before they begin treatment.
The most important effect of minoxidil or finasteride may be to prevent further hair loss. The effects last only as long as the drugs are taken.
Hormonal modulators, such as birth control pills (oral contraceptives) or spironolactone, may be useful in some women, especially those who have developed masculine characteristics.
Transplantation is a more permanent solution. In this procedure, hair follicles are removed from one part of the scalp and transplanted to the bald area. In a newer hair transplantation technique, only one or two hairs are transplanted at a time. Although this technique is more time-consuming, it does not require removal of large plugs of skin and allows the implants to be oriented in the same direction as the natural hair.
Another surgical option involves removing some bald parts of the scalp skin and stretching the parts that have hair over a wider area.
Wigs often offer the best treatment for temporary hair loss (for example, that caused by chemotherapy). People undergoing chemotherapy should consult a wig maker even before therapy begins so that an appropriate wig can be ready when needed. When hair regrows, it may be different in color and texture from the original hair.
Alopecia areata is sudden loss of patches of hair when there is no obvious cause such as a skin or general bodywide disorder.
Alopecia areata is common. It occurs in both sexes and at all ages but is most common among children and young adults. The cause is believed to be an autoimmune reaction in which the body’s immune defenses mistakenly attack the hair follicles. Alopecia areata is not the result of another disorder, but some people may also have a thyroid disorder or vitiligo (a skin pigment disorder).
Round, irregular patches of hair are suddenly lost. Around the edges of the patches are characteristic short, broken hairs, which resemble exclamation points. The site of hair loss is usually the scalp or beard. Rarely, all body hair is lost (a condition called alopecia universalis). The nails may become pitted or rough. The hair usually grows back in several months. In people with widespread hair loss, regrowth is less likely.
Doctors examine the scalp, body surface, and nails. To rule out other disorders, doctors may do testing.
Alopecia areata can be treated with corticosteroids. For small bald patches, corticosteroids are typically injected under the skin of the bald patch, and minoxidil may be applied directly to the bald patch as well. For larger patches, corticosteroids can be applied to the scalp or, more rarely, taken by mouth. Another treatment for alopecia areata involves applying irritating chemicals, such as anthralin or diphenylcyclopropenone, to the scalp to induce a mild allergic reaction or irritation. The irritation sometimes promotes hair growth.
Generic NameSelect Brand Names
anthralinNo US brand name
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