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Chondroitin Sulfate

By Melissa G. Marko, PhD, Senior Clinical Scientist, Nestle Nutrition ; Ara DerMarderosian, PhD, Professor Emeritus of Biology and Pharmacognosy, University of the Sciences

Chondroitin sulfate is a natural component of cartilage. It is extracted from shark or cow cartilage or manufactured synthetically. It is frequently combined with glucosamine.

Medicinal claims

People most often take chondroitin sulfate by mouth for osteoarthritis. For arthritis, it is frequently taken along with glucosamine. Scientific evidence shows no benefit when chondroitin sulfate is taken by itself. However, evidence suggests that combined with glucosamine, it may reduce joint pain and improve joint mobility.

Possible side effects

Chondroitin sulfate seems to have no serious side effects. Among the most common side effects are stomach pain, nausea, and other digestive tract symptoms. Other side effects include heart rate problems and swelling.

Possible drug interactions

Chondroitin sulfate may also affect the action of drugs that prevent blood clots (anticoagulants) such as warfarin. Chondroitin sulfate is safe for most people, but those who have asthma, blood-clotting disorders, or prostate cancer should use caution when taking it.

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