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S -Adenosyl- L -Methionine (SAMe)

By Melissa G. Marko, PhD, Senior Clinical Scientist, Nestle Nutrition ; Ara DerMarderosian, PhD, Professor Emeritus of Biology and Pharmacognosy, University of the Sciences

S-adenosyl-L-methionine (SAMe) is a naturally occurring agent in the human body, produced largely by the liver. It is also manufactured synthetically as a supplement.

Medicinal claims

SAMe is said to be effective in treating depression, osteoarthritis, and liver disorders, but scientific studies so far do not confirm this claim. More research is needed to verify its effectiveness.

Possible side effects

No serious side effects have been reported. People with a bipolar disorder should not use SAMe because it can cause manic episodes.

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