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Chondroitin Sulfate

By

Laura Shane-McWhorter

, PharmD, University of Utah College of Pharmacy

Reviewed/Revised Mar 2024
VIEW PROFESSIONAL VERSION

Chondroitin sulfate is a natural component of cartilage. It is extracted from shark or cow cartilage or manufactured synthetically. It is frequently combined with glucosamine Glucosamine Glucosamine is extracted from a material (chitin) present in the shells of crabs, oysters, and shrimp. Glucosamine can be applied topically in a cream or salve or taken in tablet or capsule... read more .

Claims for Chondroitin Sulfate

Evidence for Chondroitin Sulfate

Scientific evidence shows no benefit when chondroitin sulfate is taken by itself. However, evidence suggests that in combination with glucosamine, it may

  • Reduce joint pain

  • Improve joint mobility

  • Allow reduction of the doses of conventional anti-inflammatory medications, for example, when chondroitin sulfate with glucosamine is taken for 6 to 24 months

Primarily small trials studied chondroitin sulfate alone or in combination with glucosamine to treat osteoarthritis. However, the 2006 Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) was a large, placebo-controlled study of glucosamine, chondroitin sulfate, and the 2 in combination to treat osteoarthritis of the knee. Pain was not significantly reduced by either medication alone or the combination. The study suggested that people with moderate-to-severe knee pain saw some relief with the combination, but these findings require confirmation.

Side Effects of Chondroitin Sulfate

Chondroitin sulfate seems to have no serious side effects. Among the most common side effects are stomach pain, nausea, and other digestive tract symptoms. However, unless the chondroitin sulfate is pharmaceutical grade, it has the potential to transmit infections with bacteria, viruses, or prions Overview of Prion Diseases Prion diseases are rare progressive, fatal, and currently untreatable degenerative disorders of the brain (and rarely of other organs) that result when a protein changes into an abnormal form... read more .

Drug Interactions with Chondroitin Sulfate

Chondroitin sulfate taken with warfarin and possibly other medications that prevent blood clots (anticoagulants) may increase the risk of bleeding; therefore, people taking anticoagulants should avoid chondroitin sulfate.

Recommendations for Chondroitin Sulfate

Chondroitin sulfate taken in combination with glucosamine might possibly help ease symptoms of osteoarthritis Osteoarthritis (OA) Osteoarthritis is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Arthritis due to damage of joint... read more Osteoarthritis (OA) of the knee, but the effects, if any, are likely to be small. Treatment guidelines for osteoarthritis do not currently recommend using chondroitin and glucosamine.

Chondroitin sulfate appears reasonably safe, but people taking anticoagulants (such as warfarin) should not take it.

More Information

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Genicin, OptiFlex-G
Coumadin, Jantoven
NOTE: This is the Consumer Version. DOCTORS: VIEW PROFESSIONAL VERSION
VIEW PROFESSIONAL VERSION
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