Fibrocystic Changes of the Breast
(See also Overview of Breast Disorders.)
Fibrocystic changes of the breast (formerly called fibrocystic breast disease) include breast pain, cysts, and lumpiness that are not due to cancer.
Most women have some general lumpiness in the breasts, usually in the upper outer part, near the armpit. Many women have this kind of lumpiness, breast pain, breast cysts, or some combination of these symptoms—a condition called fibrocystic changes.
Normally, the levels of the female hormones estrogen and progesterone fluctuate during the menstrual cycle. Milk glands and ducts enlarge and breasts retain fluid when levels increase, and the breasts return to normal when levels decrease. (These fluctuations partly explain why breasts are swollen and more sensitive during a particular time of each menstrual cycle.) Fibrocystic changes may result from repeated stimulation by these hormones. The following increase the risk of these changes:
Other breast disorders, such as breast infections, can cause fibrocystic changes.
The lumpy areas may enlarge, causing a feeling of heaviness, discomfort, tenderness to the touch, or a burning pain. The symptoms tend to subside after menopause.
Fibrocystic changes do not increase the risk of breast cancer.
Typically, a sample of tissue from an area that appears abnormal or different from other areas must be removed and examined under a microscope (biopsy) to rule out cancer. Sometimes the sample can be removed with a needle, but sometimes it must be removed surgically.
Fibrocystic changes may make the breasts appear dense on mammograms and thus may make breast cancer more difficult to detect.
If there is only one lump or if one lump appears to be different from other lumps, the lump may be removed.
No specific treatment is available or required for fibrocystic changes, but certain measures may help relieve symptoms:
Sometimes cysts are drained, but they may recur.
If symptoms are severe, doctors may prescribe drugs, such as danazol (a synthetic male hormone) or tamoxifen (which blocks the effects of estrogen). Because side effects can occur with long-term use, the drugs are usually given for only a short time. Tamoxifen has fewer side effects than danazol.
Generic NameSelect Brand Names
danazolNo US brand name