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Percutaneous Coronary Interventions (PCI)
Percutaneous coronary interventions (PCI) include percutaneous transluminal coronary angioplasty (PTCA) with or without stent insertion. Primary indications are treatment of angina pectoris (stable or unstable), myocardial ischemia, and acute MI (particularly in patients with developing or established cardiogenic shock). Primary PTCA and stent placement within 90 min of onset of pain is the optimal treatment of transmural ST-segment–elevation MI. Elective PCI may be appropriate for post-MI patients who have recurrent or inducible angina before hospital discharge and for patients who have angina and remain symptomatic despite medical treatment. Percutaneous transluminal angioplasty (PTA) is used to treat peripheral arterial disease (see Percutaneous transluminal intervention).
PTCA is done via percutaneous femoral, radial, or brachial artery puncture. A guiding catheter is inserted into a large peripheral artery and threaded to the appropriate coronary ostium. A balloon-tipped catheter, guided by fluoroscopy or intravascular ultrasonography, is aligned within the stenosis, then inflated to disrupt the atherosclerotic plaque and dilate the artery. Angiography is repeated after the procedure to document any changes. The procedure is commonly done in 2 or 3 vessels as needed.
Stents are most useful for
Stents are now used frequently for acute MI, ostial or left main disease, chronic total occlusions, and bifurcation lesions.
Bare metal stents (BMS) are made of nickel-titanium alloy. Drug eluting stents (DES) have drugs (eg, 1st-generation: sirolimus, paclitaxel; 2nd-generation: everolimus, zotarolimus) bonded to the metal that limit neointimal proliferation to reduce the risk of restenosis. In intracoronary brachytherapy, the site of stenosis is exposed to radiation in the form of small pellets embedded in a nylon ribbon temporarily (eg, 30 min) placed in the coronary artery prior to stenting. This technique appears to decrease the risk of early restenosis, but it is unclear whether later stenosis is slightly increased; trials are ongoing. Radioactive stents have not proven effective at limiting restenosis. Biodegradable stents are currently in clinical trials.
Various anticoagulation regimens are used during and after angioplasty to reduce the incidence of thrombosis at the site of balloon dilation. Thienopyridines (clopidogrel, prasugrel, ticagrelor) and glycoprotein IIb/IIIa inhibitors are the standard of care for patients with unstable non-ST-segment elevation MI. Thienopyridines (often in combination with aspirin) are continued for 9 to 12 mo after PCI. Ca channel blockers and nitrates may also reduce risk of coronary spasm.
Absolute contraindications include
Relative contraindications include
The main complications of balloon angioplasty and stent placement are
Thrombosis causes complete blockage and may occur at any time—acutely (immediately during or after the procedure), subacutely (within 30 days), or late (> 30 days). Stent thrombosis may be due to inadequate stent expansion or apposition at the time of the procedure, discontinuation of dual antiplatelet therapy (eg, from nonadherence, need for noncardiac surgery), or both.
Restenosis is typically due to collagen deposition and thus does not occur until several weeks after the procedure or later; it may cause partial or, less commonly, complete vessel blockage. Dissection is usually detected immediately. Insertion of another stent often reopens the dissected segment.
With balloon angioplasty, risk of acute thrombosis is about 5 to 10%, risk of subacute restenosis is about 5%, and the overall restenosis rate is about 30 to 45%. Use of stents has almost eliminated the need for emergency coronary artery bypass grafting following PCI. With stent use, the rate of acute and subacute thrombosis or restenosis is < 1%. With BMS, risk of late restenosis is decreased to 20 to 30%. Use of a DES lowers late restenosis risk to about 5 to 10%. However, using a DES increases risk of late stent thrombosis, about 0.6%/yr up to 3 yr.
Complications besides restenosis are similar to those of coronary angiography, although risk of death, MI, and stroke is greater. Of all angiographic procedures, PCI has the highest risk of contrast nephropathy; this risk can be reduced by preprocedural hydration and possibly by use of a nonionic contrast agent or hemofiltration in patients with preexisting renal insufficiency. Stent placement, in addition to the above, has complications of bleeding secondary to aggressive adjunctive anticoagulation, side branch occlusion, and stent embolism.
Drug NameSelect Brand Names
aspirinNo US brand name
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