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Introduction to Factors Affecting Response to Drugs

by Daniel A. Hussar, PhD

Response to a drug depends partly on the patient’s characteristics and behaviors (eg, consumption of foods or supplements; adherence to a dosing regimen; differences in metabolism due to age, sex, race, genetic polymorphisms, or hepatic or renal insufficiency), coexistence of other disorders, and use of other drugs. Drug errors (see Drug Errors), including prescribing an inappropriate drug, misreading a prescription, or administering a drug incorrectly, also can affect response.

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