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Drug errors contribute to morbidity. They are estimated to cost the US health care system up to $177 billion (depending on definitions) annually. Drug errors may involve
Errors in prescribing are common, especially for certain populations. The elderly (see Drug Therapy in the Elderly, especially see Table 5: Drug Therapy in the Elderly: High-Risk Drugs in the Elderly (Based on the Beers Criteria) ), women of childbearing age, and children are particularly at risk. Drug interactions particularly affect those taking many drugs. To minimize risk, clinicians should know all drugs being taken—including those prescribed by others and OTC drugs—and keep a complete problem list. Patients should be encouraged to write and update a list of their current drugs and dosages and bring the list to every health care appointment or emergency department visit. If there is any doubt as to which drugs are being used, patients should be instructed to bring all their drugs to their health care appointments for review.
Prescriptions must be written as clearly as possible. The names of some drugs are similar and, if not written clearly, cause confusion. Changing some traditional but easily confused notations may also help reduce errors. For example, “qd” (once/day) may be confused with “qid” (4 times/day). Writing “once/day” or “once a day” is preferred. Electronically transmitted or computer-printed prescriptions can avoid problems with illegible handwriting or inappropriate abbreviations.
Drugs may be given incorrectly, especially in institutions. A drug may be given to the wrong patient, at the wrong time, or by the wrong route. Certain drugs must be given slowly when given IV, and some drugs cannot be given simultaneously. When an error is recognized, it should be reported immediately to a clinician, and a pharmacist should be consulted. Bar codes and computerized pharmacy systems may help decrease the incidence of drug errors.
A pharmacist should store drugs in a manner that ensures their potency. Mail-order pharmacies should follow procedures to ensure proper transportation. Storage by patients is often suboptimal. If stored incorrectly, drugs are likely to decrease in potency long before the stated expiration date. Labeling should clearly state whether a drug needs to be stored in the refrigerator or kept cool, needs to be kept out of excessive heat or sun, or otherwise requires special storage. On the other hand, unnecessary precautions decrease adherence and waste the patient's time. For example, unopened insulin should be refrigerated, but a bottle in use can be stored safely outside the refrigerator for a relatively long time if not exposed to excessive heat and sun.
Use of outdated drugs is common. Outdated drugs are likely to be ineffective and some (eg, aspirin, tetracycline) can be harmful if used when outdated.
Most commonly, drug error results from a patient's confusion about how to take drugs. Patients may take the wrong drug or dose. Dosing instructions for each drug, including why the drug has been prescribed, should be completely explained to patients and given in writing when possible. They should be advised to ask their pharmacist for additional advice about taking their drugs. Packaging should be convenient but safe. If children will not have access to the drug and patients may have difficulty opening the container, drugs do not need to be provided in childproof containers.
Last full review/revision January 2010 by Daniel A. Hussar, PhD
Content last modified January 2010
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