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Rosacea

(Acne Rosacea)

by Karen McKoy, MD, MPH

Rosacea (acne rosacea) is a chronic inflammatory disorder characterized by facial flushing, telangiectasias, erythema, papules, pustules, and, in severe cases, rhinophyma. Diagnosis is based on the characteristic appearance and history. Treatment depends on severity and includes topical metronidazole, topical and oral antibiotics, rarely isotretinoin, and, for severe rhinophyma, surgery.

Rosacea most commonly affects patients aged 30 to 50 with fair complexions, most notably those of Irish and Northern European descent, but it affects and is probably under-recognized in darker-skinned patients.

Etiology of Rosacea

The etiology of rosacea is unknown, but some proposed associations include

  • Abnormal vasomotor control

  • Impaired facial venous drainage

  • Increased follicle mites ( Demodex folliculorum)

  • Increased angiogenesis, ferritin expression, and reactive oxygen species

  • Dysfunction of antimicrobial peptides (eg, cathelicidin)

Diet plays no consistent role, but some agents (eg, amiodarone, topical and nasal corticosteroids, high doses of B 6 and B 12 ) may worsen rosacea.

Symptoms and Signs of Rosacea

Rosacea is limited to the face and scalp and manifests in 4 phases:

  • Pre-rosacea

  • Vascular

  • Inflammatory

  • Late

In the pre-rosacea phase, patients describe embarrassing flushing and blushing, often accompanied by uncomfortable stinging. Common reported triggers for these flares include sun exposure, emotional stress, cold or hot weather, alcohol, spicy foods, exercise, wind, cosmetics, and hot baths or hot drinks. These symptoms persist throughout other phases of the disorder.

In the vascular phase, patients develop facial erythema and edema with multiple telangiectases, possibly as a result of persistent vasomotor instability.

An inflammatory phase often follows, in which sterile papules and pustules (leading to the designation of rosacea as adult acne) develop.

The late phase (developing in some patients), is characterized by coarse tissue hyperplasia of the cheeks and nose (rhinophyma) caused by tissue inflammation, collagen deposition, and sebaceous gland hyperplasia.

The phases of rosacea are usually sequential. Some patients go directly into the inflammatory stage, bypassing the earlier stages. Treatment may cause rosacea to return to an earlier stage. Progression to the late stage is not inevitable.

Ocular rosacea often precedes or accompanies facial rosacea and manifests as some combination of blepharoconjunctivitis, iritis, scleritis, and keratitis, causing itching, foreign body sensation, erythema, and edema of the eye.

Diagnosis of Rosacea

  • Clinical evaluation

Diagnosis is based on the characteristic appearance; there are no specific diagnostic tests. The age of onset and absence of comedones help distinguish rosacea from acne.

Differential diagnosis includes acne vulgaris, SLE, sarcoidosis, photodermatitis, drug eruptions (particularly caused by iodides and bromides), granulomas of the skin, and perioral dermatitis.

Treatment of Rosacea

  • Avoidance of triggers

  • Consideration of topical or oral antibiotics or azelaic acid

  • For flushing or persistent erythema, consideration of topical brimonidine

  • For recalcitrant cases, consideration of oral isotretinoin

  • For rhinophyma, consideration of dermabrasion and tissue excision

  • For telangiectasia, consideration of laser or electrocautery treatment

Primary initial treatment of rosacea involves avoidance of triggers (including use of sunscreen). Antibiotics and/or azelaic acid may be used for inflammatory disease. The objective of treatment is control of symptoms, not cure.

Metronidazole cream 1%, lotion (0.75%), or gel (0.75%) and azelaic acid 20% cream, applied bid, are equally effective; 2.5% benzoyl peroxide in any form (eg, gel, lotion, cream), applied once/day or bid, can be added for improved control. Less effective alternatives include sodium sulfacetamide 10%/sulfur 5% lotion; clindamycin 1% solution, gel, or lotion; and erythromycin 2% solution, all applied bid. Many patients require indefinite treatment for long-term control.

Oral antibiotics are indicated for patients with multiple papules or pustules and for those with ocular rosacea; options include tetracycline 250 to 500 mg bid, doxycycline 50 to 100 mg bid, minocycline 50 to 100 mg bid, and erythromycin 250 to 500 mg bid. Dose should be reduced to the lowest one that controls symptoms once a beneficial response is achieved. Subantimicrobial doses of doxycycline are effective for acne and rosacea.

Persistent erythema or flushing may be treated with topical α 2 -selective adrenergic agonist brimonidine 0.33% gel applied once/day.

Recalcitrant cases may respond to oral isotretinoin.

Techniques for treatment of rhinophyma include dermabrasion and tissue excision; cosmetic results are good.

Techniques for treatment of telangiectasia include laser and electrocautery.

Key Points

  • Consider rosacea if patients have flushing and blushing, with or without stinging, often triggered by sun exposure, emotional stress, cold or hot weather, alcohol, spicy foods, exercise, wind, cosmetics, or hot baths or hot drinks.

  • Diagnose rosacea by its typical appearance (eg, central facial erythema and edema with or without pustules, papules, or multiple telangiectases).

  • Treat rosacea with avoidance of triggers; treat inflammation, depending on severity, with topical antibiotics and/or azelaic acid, oral antibiotics, or isotretinoin.

  • Consider brimonidine for persistent erythema or flushing.

  • Dermabrasion and tissue excision for rhinophyma give good cosmetic results.

  • Consider laser or electrocautery for telangiectasia.

Resources In This Article

Drugs Mentioned In This Article

  • Drug Name
    Select Trade
  • FLAGYL
  • SOTRET
  • CORDARONE
  • MINOCIN
  • ACHROMYCIN V
  • PERIOSTAT, VIBRAMYCIN
  • ERY-TAB, ERYTHROCIN
  • ALPHAGAN P
  • CLEOCIN
  • BLEPH-10

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