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Vocal Cord Paralysis

by Clarence T. Sasaki, MD

Vocal cord paralysis has numerous causes and can affect speaking, breathing, and swallowing. The left vocal cord is affected twice as often as the right, and females are affected more often than males (3:2). Diagnosis is based on direct visualization. An extensive assessment may be necessary to determine the cause. Several direct surgical approaches are available if treating the cause is not curative.

Vocal cord paralysis may result from lesions at the nucleus ambiguus, its supranuclear tracts, the main trunk of the vagus, or the recurrent laryngeal nerves.

Unilateral vocal cord paralysis is most common. About one third of unilateral paralyses are neoplastic in origin, one third are traumatic, and one third are idiopathic. Intracranial tumors, vascular accidents, and demyelinating diseases cause nucleus ambiguus paralysis. Tumors at the base of the skull and trauma to the neck cause vagus paralysis. Recurrent laryngeal nerve paralysis is caused by neck or thoracic lesions (eg, aortic aneurysm; mitral stenosis; mediastinal tuberculous adenitis; tumors of the thyroid gland, esophagus, lung, or mediastinal structures), trauma, thyroidectomy, neurotoxins (eg, lead, arsenic, mercury), neurotoxic infections (eg, diphtheria), cervical spine injury or surgery, Lyme disease, and viral illness. Viral neuronitis probably accounts for most idiopathic cases.

Bilateral vocal cord paralysis is a life-threatening disorder caused by thyroid and cervical surgery, tracheal intubation, trauma, and neurodegenerative and neuromuscular diseases.

Symptoms and Signs

Vocal cord paralysis results in loss of vocal cord abduction and adduction. Paralysis may affect phonation, respiration, and deglutition, and food and fluids may be aspirated into the trachea. The paralyzed cord generally lies 2 to 3 mm lateral to the midline. In recurrent laryngeal nerve paralysis, the cord may move with phonation but not with inspiration. In unilateral paralysis, the voice may be hoarse and breathy, but the airway is usually not obstructed because the normal cord abducts sufficiently. In bilateral paralysis, both cords generally lie within 2 to 3 mm of the midline, and the voice is of good quality but of limited intensity. The airway, however, is inadequate, resulting in stridor and dyspnea with moderate exertion as each cord is drawn to the midline glottis by an inspiratory Bernoulli effect. Aspiration is also a danger.

Diagnosis

  • Laryngoscopy

  • Various tests for possible causes

Diagnosis is based on laryngoscopy. The cause must always be sought. Evaluation is guided by abnormalities identified on history and physical examination. During the history, the physician asks about all possible causes of peripheral neuropathy, including chronic heavy metal exposure (arsenic, lead, mercury), drug effects from phenytoin and vincristine, and history of connective tissue disorders, Lyme disease, sarcoidosis, diabetes, and alcoholism. Further evaluation may include enhanced CT or MRI of the head, neck, and chest; thyroid scan; barium swallow or bronchoscopy; and esophagoscopy. Cricoarytenoid arthritis, which may cause fixation of the cricoarytenoid joint, must be differentiated from a neuromuscular etiology. Fixation is best documented by absence of passive mobility during rigid laryngoscopy under general anesthesia. Cricoarytenoid arthritis may complicate such conditions as RA, external blunt trauma, and prolonged endotracheal intubation.

Treatment

  • For unilateral paralysis, surgical procedures to move cords closer together

  • For bilateral paralysis, surgical procedures and measures to maintain airway

In unilateral paralysis, treatment is directed at improving voice quality through augmentation, medialization, or reinnervation.

Augmentation involves injecting a paste of plasticized particles, collagen, micronized dermis, or autologous fat into the paralyzed cord, bringing the cords closer together to improve the voice and prevent aspiration.

Medialization is shifting the vocal cord toward the midline by inserting an adjustable spacer laterally to the affected cord. This can be done with a local anesthetic, allowing the position of the spacer to be “tuned” to the patient’s voice. Unlike augmentation with plasticized particles, which permanently fixes the cord, the spacer is both adjustable and removable.

Reinnervation has only rarely been successful.

In bilateral paralysis, an adequate airway must be reestablished. Tracheotomy may be needed permanently or temporarily during a URI. An arytenoidectomy with lateralization of the true vocal cord opens the glottis and improves the airway but may adversely affect voice quality. Posterior laser cordectomy opens the posterior glottis and may be preferred to endoscopic or open arytenoidectomy. Successful laser establishment of a posterior glottic airway usually obviates the need for long-term tracheotomy while preserving a serviceable voice quality.

Key Points

  • Vocal cord paralysis can be caused by a lesion anywhere on the neural pathway to the larynx (the nucleus ambiguus, its supranuclear tracts, the main trunk of the vagus, the recurrent laryngeal nerves).

  • Most paralyses are unilateral and affect mainly the voice, but bilateral paralysis can occur and obstruct the airway.

  • Paralysis is diagnosed by direct laryngoscopy, but identification of the cause typically requires imaging (eg, MRI) and other tests.

  • Patients with bilateral paralysis often require tracheal intubation initially.

  • Various surgical procedures are available to improve voice quality in unilateral paralysis or to improve airway patency in long-term bilateral paralysis.

Drugs Mentioned In This Article

  • Drug Name
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  • MARQIBO KIT
  • DILANTIN

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