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Nasopharyngeal Cancer

by Bradley A. Schiff, MD

Nasopharyngeal cancers are rare in the US but common in the South China Sea region. Symptoms develop late, including unilateral bloody nasal discharge, nasal obstruction, hearing loss, ear pain, facial swelling, and facial numbness. Diagnosis is based on inspection and biopsy, with CT, MRI, or PET to evaluate extent. Treatment is with radiation, chemotherapy, and, rarely, surgery.

Squamous cell carcinoma is the most common malignant tumor of the nasopharynx. It can occur in any age group and is rare in North America. It is one of the most common cancers among people of Chinese, especially southern Chinese, and Southeast Asian ancestry, including Chinese immigrants to North America. Over several generations, the prevalence among Chinese-Americans gradually decreases to that among non-Chinese Americans, suggesting an environmental component to etiology. Dietary exposure to nitrites and salted fish also is thought to increase risk. Epstein-Barr virus is a significant risk factor, and there is hereditary predisposition. Other nasopharyngeal cancers include adenoid cystic and mucoepidermoid carcinomas, malignant mixed tumors, adenocarcinomas, lymphomas, fibrosarcomas, osteosarcomas, chondrosarcomas, and melanomas.

Symptoms and Signs

The first symptom is often nasal or eustachian tube obstruction causing hearing loss due to a middle ear effusion. Other symptoms include ear pain, purulent bloody rhinorrhea, frank epistaxis, cranial nerve palsies, and cervical lymphadenopathy. Cranial nerve palsies most often involve the 6th, 4th, and 3rd cranial nerves due to their location in the cavernous sinus, in close proximity to the foramen lacerum, which is the most common route of intracranial spread for these tumors. Because lymphatics of the nasopharynx communicate across the midline, bilateral metastases are common.


  • Nasopharyngeal endoscopy and biopsy

  • Imaging tests for staging

Patients suspected of having nasopharyngeal cancer must undergo examination with a nasopharyngeal mirror or endoscope, and lesions are biopsied. Open cervical node biopsy should not be done as the initial procedure (see Neck Mass), although a needle biopsy is acceptable and often recommended. Gadolinium-enhanced MRI (with fat suppression) of the head with attention to the nasopharynx and skull base is done; the skull base is involved in about 25% of patients. CT also is required to accurately assess skull base bony changes, which are less visible on MRI. A PET scan also commonly is done to assess the extent of disease as well as the cervical lymphatics.


Patients with early-stage disease (see Table: Staging of Head and Neck Cancer) typically have a good outcome (5-yr survival is 60 to 75%), whereas patients with stage IV disease have a poor outcome (5-yr survival is < 40%).


  • Chemotherapy plus radiation therapy

Because of the location and extent of involvement, nasopharyngeal cancers often are not amenable to surgical resection. They are typically treated with chemotherapy and radiation therapy, which are often followed by adjuvant chemotherapy.

Recurrent tumors can be treated with another course of radiation, commonly with brachytherapy; radionecrosis of the skull base is a risk. An alternative to radiation is skull base resection. Resection is usually done by removing part of the maxilla for access but sometimes resection can be done endoscopically.

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