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Tinnitus

By

David M. Kaylie

, MS, MD, Duke University Medical Center

Reviewed/Revised Dec 2022
View PATIENT EDUCATION
Topic Resources

Tinnitus is a noise in the ears. It is experienced by 10 to 15% of the population.

Subjective tinnitus is perception of sound in the absence of an acoustic stimulus and is heard only by the patient. Most tinnitus is subjective.

Objective tinnitus is uncommon and results from noise generated by structures near the ear. Sometimes the tinnitus is loud enough to be heard by the examiner.

Characteristics

Tinnitus may be described as buzzing, ringing, roaring, whistling, or hissing and is sometimes variable and complex. Objective tinnitus typically is pulsatile (synchronous with the heartbeat) or intermittent. Tinnitus is most noticeable in quiet environments and in the absence of distracting stimuli and, thus, frequently seems worse at bedtime.

Tinnitus may be intermittent or continuous. Continuous tinnitus is at best annoying and is often quite distressing. Some patients adapt to its presence better than others; depression occasionally results. Stress generally exacerbates tinnitus.

Pathophysiology of Tinnitus

Subjective tinnitus is thought to be caused by abnormal neuronal activity in the auditory cortex. This activity results when input from the auditory pathway (cochlea, auditory nerve, brain stem nuclei, auditory cortex) is disrupted or altered in some manner. This disruption may cause loss of suppression of intrinsic cortical activity and perhaps creation of new neural connections. Some believe the phenomenon is similar to the development of phantom limb pain after amputation. Conductive hearing loss Pathophysiology Pathophysiology (eg, caused by cerumen impaction, otitis media, or eustachian tube dysfunction) may also be associated with subjective tinnitus, by altering sound input to the central auditory system.

Objective tinnitus represents actual noise generated by physiologic phenomena occurring near the middle ear. Usually the noise comes from blood vessels, either normal vessels in conditions of increased or turbulent flow (eg, caused by atherosclerosis) or abnormal vessels (eg, in tumors or vascular malformations). Sometimes muscle spasms or myoclonus of palatal muscles or muscles in the middle ear (stapedius, tensor tympani) cause clicking sounds.

Etiology of Tinnitus

Causes may be considered by whether they cause subjective or objective tinnitus (see table ).

Subjective tinnitus

Subjective tinnitus may occur with almost any disorder affecting the auditory pathways.

The most common disorders are those that involve sensorineural hearing loss Pathophysiology Pathophysiology , particularly

Infections and central nervous system lesions (eg, caused by tumor, stroke, multiple sclerosis) that affect auditory pathways also may be responsible.

Disorders causing conductive hearing loss also may cause tinnitus. These include obstruction of the ear canal by cerumen External Ear Obstructions The ear canal may be obstructed by cerumen (earwax), scar tissue, a tumor, a foreign body, or an insect. Itching, pain, and temporary conductive hearing loss may result. Most causes of obstruction... read more , a foreign body External Ear Obstructions The ear canal may be obstructed by cerumen (earwax), scar tissue, a tumor, a foreign body, or an insect. Itching, pain, and temporary conductive hearing loss may result. Most causes of obstruction... read more , or external otitis External Otitis (Acute) External otitis is an acute infection of the ear canal skin typically caused by bacteria; Pseudomonas is most common. Symptoms include pain, discharge, and hearing loss if the ear canal... read more External Otitis (Acute) . Otitis media Otitis Media (Acute) Acute otitis media is a bacterial or viral infection of the middle ear, usually accompanying an upper respiratory infection. Symptoms include otalgia, often with systemic symptoms (eg, fever... read more Otitis Media (Acute) , barotrauma Otic Barotrauma Otic barotrauma is ear pain or damage to the tympanic membrane caused by rapid changes in environmental pressure. To maintain equal pressure on both sides of the tympanic membrane, gas must... read more , eustachian tube dysfunction, and otosclerosis Otosclerosis Otosclerosis is a disease of the bone of the otic capsule that causes an abnormal accumulation of new bone, most commonly within the oval window. Otosclerosis is one of many genetic and acquired... read more may also be associated with tinnitus.

Objective tinnitus

Objective tinnitus usually involves noise from vascular flow, which causes an audible pulsating sound synchronous with the pulse. Causes include

  • Turbulent flow through the carotid artery or jugular vein

  • Highly vascular middle ear tumors

  • Dural arteriovenous malformations (AVMs)

Muscle spasms or myoclonus of palatal muscles or those of the middle ear (stapedius, tensor tympani) may cause perceptible noise, typically a rhythmic clicking. Such spasms may be idiopathic or caused by tumors, head trauma, and infectious or demyelinating diseases (eg, multiple sclerosis). Palatal myoclonus causes visible movement of the palate, tympanic membrane, or both that coincides with tinnitus.

Table

Evaluation of Tinnitus

History

History of present illness should note duration of tinnitus, whether it is in one or both ears, and whether it is a constant tone or intermittent. If intermittent, the clinician should determine whether it is regular and whether it is about the rate of the pulse or sporadic. Any exacerbating or relieving factors (eg, swallowing, head position) should be noted. Important associated symptoms include hearing loss, vertigo, ear pain, and ear discharge.

Review of systems should seek symptoms of possible causes, including diplopia and difficulty swallowing or speaking (lesions of the brain stem) and focal weakness and sensory changes (peripheral nerve disorders, including dysfunction of the 8th cranial nerve). The impact of the tinnitus on the patient also should be assessed. Whether the tinnitus is sufficiently distressing to cause significant anxiety, depression, or sleeplessness should be noted.

Past medical history should ask about risk factors for tinnitus, including exposure to loud noise, sudden pressure change (from diving or air travel), history of ear or central nervous system infections or trauma, radiation therapy to the head, and recent major weight loss (risk of eustachian dysfunction). Drug use should be ascertained, particularly any salicylates, aminoglycosides, or loop diuretics.

Physical examination

Physical examination focuses on the ear and the nervous system.

The ear canal should be inspected for discharge, foreign body, and cerumen. The tympanic membrane should be inspected for signs of acute infection (eg, redness, bulging), chronic infection (eg, perforation, cholesteatoma), and tumor (red or bluish mass). A bedside hearing test Physical examination Worldwide, about half a billion people (almost 8% of the world's population) have hearing loss ( 1). More than 10% of people in the US have some degree of hearing loss that compromises their... read more Physical examination should be done, including Weber and Rinne tests Physical examination Physical examination using a 512-Hz tuning fork.

Cranial nerves, particularly vestibular function (see Dizziness and Vertigo Dizziness and Vertigo Dizziness is an imprecise term patients often use to describe various related sensations, including Faintness (a feeling of impending syncope) Light-headedness Feeling of imbalance or unsteadiness... read more Dizziness and Vertigo ), are tested along with peripheral strength, sensation, and reflexes. A stethoscope is used to listen for vascular noise over the course of the carotid arteries and jugular veins and over and adjacent to the ear.

Red flags

The following findings are of particular concern:

  • Bruit, particularly over the ear or skull

  • Accompanying neurologic symptoms or signs (other than hearing loss)

  • Unilateral tinnitus

Interpretation of findings

In some cases, tinnitus may indicate retrocochlear pathology, such as an vestibular schwannoma Vestibular Schwannoma A vestibular schwannoma (acoustic neuroma) is a Schwann cell–derived tumor of the 8th cranial nerve. Symptoms include unilateral hearing loss. Diagnosis is based on audiology and confirmed by... read more (benign but invasive tumor originating from the vestibular portion of the 8th cranial nerve in the internal auditory canal).

It is important to note whether the tinnitus is unilateral because vestibular schwannomas may manifest only with unilateral tinnitus. This diagnosis is more likely if there is also unilateral sensorineural hearing loss or asymmetric hearing loss with worse hearing in the ear with tinnitus.

It also is important to distinguish the uncommon cases of objective tinnitus from the more common cases of subjective tinnitus. Tinnitus that is pulsatile or intermittent is almost always objective (although not always detectable by the examiner), as is that associated with a bruit. Pulsatile tinnitus is nearly always benign. Continuous tinnitus is usually subjective (except perhaps for that caused by a venous hum, which may be identified by presence of a bruit and often by a change in tinnitus with head rotation or jugular vein compression).

Specific causes can often be suspected by findings on examination (see table ). In particular, exposure to loud noise, barotrauma, or certain drugs before onset suggests those factors as the cause.

Testing

In patients with unilateral tinnitus and hearing loss, vestibular schwannoma should be ruled out by gadolinium-enhanced MRI. In patients with unilateral tinnitus and normal hearing and physical examination, MRI is not necessary unless tinnitus persists > 6 months.

Other testing depends on patient presentation (see table ).

Patients with visible evidence of a vascular tumor in the middle ear require CT, gadolinium-enhanced MRI, and referral to a subspecialist if the diagnosis is confirmed.

Patients with pulsatile, objective tinnitus and no ear abnormalities on examination or audiology require further investigation of the vascular system (carotid, vertebral, and intracranial vessels). The usual test sequence is to begin with CT angiography (CTA). However, because CTA is not very sensitive for dural AVMs, many clinicians then consider doing an MR angiogram or conventional arteriogram. Because dural AVMs are rare, the significant risks of arteriography must be weighed against the potential benefit of diagnosis and treatment (with embolization) of this vascular anomaly.

Patients who report hearing clicking sounds in one or both ears should be evaluated for the presence of objective tinnitus. This evaluation may be done by auscultation using a stethoscope or with tympanometry to identify clonus of the tensor tympani, stapedius, and/or palatal muscles. Palatal myoclonus should be visible on physical exam of the oral cavity.

Treatment of Tinnitus

Because stress and other mental factors (eg, depression) can exacerbate symptoms, efforts to recognize and treat these factors may help. Many patients are reassured by learning that their tinnitus does not represent a serious medical problem. Tinnitus also can be worsened by caffeine and other stimulants, so patients should try eliminating use of these substances.

Although no specific medical or surgical therapy is available, many patients find that background sound masks the tinnitus and may help them fall asleep. Some patients benefit from a tinnitus masker, a device worn like a hearing aid that provides a low-level sound that can cover up the tinnitus. Tinnitus retraining therapy, offered by programs that specialize in tinnitus treatment, are helpful for some patients. Electrical stimulation of the inner ear, as with a cochlear implant, occasionally reduces the tinnitus but is appropriate only for patients who are profoundly deaf.

Geriatrics Essentials: Tinnitus

One out of 4 people > 65 years has significant hearing impairment. Because tinnitus is common among people with sensorineural hearing loss, tinnitus is a common complaint among older patients.

Key Points

  • Subjective tinnitus is caused by an abnormality somewhere in the auditory pathway.

  • Objective tinnitus is caused by an actual noise produced in a vascular structure near the ear.

  • Loud noise, aging, Meniere disease, migraines, and drugs are the most common causes of subjective tinnitus.

  • Unilateral tinnitus with hearing loss or dizziness/dysequilibrium warrants gadolinium-enhanced MRI to rule out vestibular schwannoma.

  • Any tinnitus accompanied by a neurologic deficit should prompt neurologic evaluation.

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