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Flexible endoscopes equipped with video cameras can be used to view the upper GI tract from pharynx to upper duodenum and the lower GI tract from anus to cecum (and, sometimes, terminal ileum). Several other diagnostic and therapeutic interventions also can be done endoscopically. The potential to combine diagnosis and therapy in one procedure gives endoscopy a significant advantage over procedures that provide only imaging (eg, x-ray contrast studies, CT, MRI) and often outweighs endoscopy's higher cost and need for sedation.
Diagnostic procedures include the use of ultrasound-equipped endoscopes to evaluate blood flow or provide imaging of lesions. Endoscopic ultrasound can provide information (eg, the depth and extent of lesions) that is not available via conventional endoscopy. Other diagnostic procedures include cell and tissue sample collection by brush or biopsy forceps.
Screening colonoscopy is recommended for patients at high risk of colon cancer and for everyone ≥ 50. Colonoscopy should be done every 10 yr for patients with no risk factors and with a normal initial colonoscopy. CT colonography (see Diagnostic and Therapeutic GI Procedures: CT scanning of the abdomen) is an alternative to colonoscopy for screening for colonic tumors.
Therapeutic endoscopic procedures include removal of foreign bodies; hemostasis by thermal coagulation, laser photocoagulation, variceal banding, or sclerotherapy; debulking of tumors by laser or bipolar electrocoagulation; dilation of webs or strictures; stent placement; reduction of volvulus or intussusception; and decompression of acute or subacute colonic dilatation.
Absolute contraindications to endoscopy include
Relative contraindications include poor patient cooperation, coma (unless the patient is intubated), and cardiac arrhythmias or recent myocardial ischemia.
Patients taking anticoagulants or chronic NSAID therapy can safely undergo diagnostic endoscopy. However, if there is a possibility that biopsy or photocoagulation will be done, these drugs should be stopped for an appropriate interval before the procedure. Oral iron-containing drugs should be stopped 4 to 5 days before colonoscopy, because certain green vegetables interact with iron to form a sticky residue that is difficult to remove with a bowel preparation and interferes with visualization. The American Heart Association no longer recommends endocarditis prophylaxis for patients having GI endoscopy.
Routine preparations for endoscopy include no solids for 6 to 8 h and no liquids for 4 h before the procedure. Additionally, colonoscopy requires cleansing of the colon. A variety of regimens may be used, but all typically include a full or clear liquid diet for 24 to 48 h and some type of laxative, with or without an enema. A common laxative preparation involves having the patient drink a high-volume (4 L) balanced electrolyte solution over a period of 3 to 4 h before the procedure. Patients who cannot tolerate this solution may be given Mg citrate, Na phosphate, lactulose, or other laxatives. Enemas can be done with either Na phosphate or tap water. Phosphate preparations should not be used in patients with renal insufficiency.
Endoscopy generally requires IV sedation and, for upper endoscopy, topical anesthesia of the throat. Exceptions are anoscopy and sigmoidoscopy (see Diagnostic and Therapeutic GI Procedures: Anoscopy and Sigmoidoscopy), which generally require nothing. The overall complication rate of endoscopy is 0.1 to 0.2%; mortality is about 0.03%. Complications are usually drug related (eg, respiratory depression); procedural complications (eg, aspiration, perforation, significant bleeding) are less common.
Video capsule endoscopy:
In video capsule endoscopy (wireless video endoscopy), patients swallow a capsule containing a camera that transmits images to an external recorder. This noninvasive technology provides diagnostic imaging of the small bowel that is otherwise difficult to obtain. This procedure is particularly useful in patients with occult GI bleeding. Capsule endoscopy is more difficult in the colon; products and procedures are under development.
Last full review/revision March 2009 by Norton J. Greenberger, MD
Content last modified March 2009
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