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Drug- and Chemical-Related Gastroenteritis

Many drugs cause nausea, vomiting, and diarrhea as adverse effects. A detailed drug history must be obtained. In mild cases, cessation followed by reuse of the drug may establish a causal relationship. Commonly responsible drugs include antacids containing Mg, antibiotics, antihelminthics, cytotoxics (used in cancer therapy), colchicineSome Trade Names
No US trade name
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, digoxinSome Trade Names
DIGITEK
LANOXIN
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, heavy metals, laxatives, and radiation therapy. Use of antibiotics may lead to Clostridium difficile–induced diarrhea (see Anaerobic Bacteria: Clostridium difficile–Induced Diarrhea).

Iatrogenic, accidental, or intentional heavy-metal poisoning frequently causes nausea, vomiting, abdominal pain, and diarrhea.

Laxative abuse, sometimes denied by patients, may lead to weakness, vomiting, diarrhea, electrolyte depletion, and metabolic disturbances.

Various plants and mushrooms cause a syndrome of gastroenteritis (see Poisoning: Mushroom Poisoning).

Last full review/revision September 2007 by Thomas G. Boyce, MD, MPH

Content last modified September 2007

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