Search
 
Overview of High Risk Pregnancy

In a high-risk (at-risk) pregnancy, the mother, fetus, or neonate is at increased risk of morbidity or mortality before or after delivery.

In the US, overall maternal mortality rate is 6/100,000 deliveries; incidence is 3 to 4 times higher in nonwhite women. The most common causes of death are hemorrhage, preeclampsia, pulmonary embolism, and infection.

Perinatal mortality rate in offspring is 11.5/1000 deliveries: 6.7/1000 are fetal, and 4.8/1000 are neonatal (age < 28 days). The most common causes of death are congenital malformations and preterm delivery.

Risk assessment is part of routine prenatal care. Risk is also assessed during or shortly after labor and at any time that events may modify risk status. Risk factors (see Table 1: High-Risk Pregnancy: Pregnancy Risk AssessmentTables) are assessed systematically because each risk factor present increases overall risk. High-risk pregnancies require close monitoring and sometimes referral to a perinatal center. When referral is needed, transfer before rather than after delivery results in lower neonatal morbidity and mortality rates. The most common reasons for referral before delivery are

Table 1

Pregnancy Risk Assessment

Category

Risk Factors

Score*

Preexisting

Cardiovascular and renal disorders

Moderate to severe preeclampsia

Chronic hypertension

Moderate to severe renal disorders

Severe heart failure (class II–IV, NYHA classification)

10

10

10

10

History of eclampsia

History of pyelitis (infection of the renal pelvis)

Mild heart failure (class I, NYHA classification)

Mild preeclampsia

Acute pyelonephritis

5

5

5

5

5

History of cystitis

Acute cystitis

History of preeclampsia

1

1

1

Metabolic disorders

Insulin-dependent diabetes

Previous endocrine ablation

10

10

Thyroid disorders

Gestational diabetes

5

5

Family history of diabetes

1

Obstetric history

Fetal exchange transfusion because of Rh incompatibility

Stillbirth

Late abortion (16–20 wk)

Postterm pregnancy (> 42 wk)

Preterm neonate (< 37 wk and < 2500 g)

Intrauterine growth restriction (weight < 10th percentile for estimated gestational age)

Abnormal fetal position

Polyhydramnios (hydramnios)

Multifetal pregnancy

Previous brachial plexus injury

10

10

10

10

10

10

10

10

10

10

Neonatal death

Cesarean delivery

Habitual ( 3) abortion

Neonate > 4.5 kg

Shoulder dystocia

Multiparity of > 5

Seizure disorders or cerebral palsy

5

5

5

5

5

5

5

Fetal malformations

1

Other disorders

Abnormal cervical cytologic findings

Sickle cell disease

Thrombophilia

10

10

10

Positive serologic results for STDs

Severe anemia (Hb < 9 g/dL)

History of TB or purified protein derivative injection site induration 10 mm

Pulmonary disorders

5

5

5

5

Mild anemia (Hb 9.0–10.9 g/dL)

1

Anatomic abnormalities

Uterine malformation

Insufficient (incompetent) cervix

10

10

Small pelvis

5

Maternal characteristics

Age 35 or 15 yr

Weight < 45.5 or > 91 kg

5

5

Psychiatric disorder or intellectual disability (mental retardation)

1

Antepartum

Exposure to teratogens

Certain viral infections (eg, rubella, cytomegalovirus infection)

Flu syndrome (severe)

Excessive use of drugs

5

5

5

Smoking 1 pack/day

Alcohol (moderate to severe)

1

1

Pregnancy complications

Rh sensitization only

Vaginal spotting

5

5

Intrapartum

Maternal

Moderate to severe preeclampsia

Polyhydramnios (hydramnios) or oligohydramnios

Uterine rupture

Postterm (> 42 wk)

10

10

10

10

Mild preeclampsia

Premature rupture of membranes > 12 h

Preterm labor

Primary dysfunctional labor

Secondary arrest of dilation

Labor > 20 h

Second stage > 2.5 h

Medical induction of labor

Precipitous labor (< 3 h)

Primary cesarean delivery

Repeat cesarean delivery

5

5

5

5

5

5

5

5

5

5

5

Elective induction of labor

Prolonged latent phase

OxytocinSome Trade Names
PITOCIN
SYNTOCINON
Click for Drug Monograph
augmentation

1

1

1

Placental

Placenta previa

Abruptio placentae

Chorioamnionitis

10

10

10

Fetal

Abnormal presentation (breech, brow, face) or transverse lie

Multifetal pregnancy

Fetal bradycardia > 30 min

Prolapsed cord

Fetal weight < 2.5 kg

Fetal acidosis pH 7

Fetal tachycardia > 30 min

10

10

10

10

10

10

10

Operative delivery using vacuum extractor or forceps

Breech delivery, spontaneous or assisted

5

5

*A score of ≥ 10 indicates a high risk.

NYHA = New York Heart Association; STDs = sexually transmitted diseases.

  • Preterm labor (often due to premature rupture of the membranes)
  • Preeclampsia
  • Hemorrhage

Last full review/revision January 2009 by Christian M. Briery, MD; John Morrison, MD

Content last modified January 2009

Back to Top

Previous: Anemia in Pregnancy

Next: Risk Factors for Complications During Pregnancy

Audio
Figures
Photographs
Tables
Videos

Copyright     © 2010-2011 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Whitehouse Station, N.J., U.S.A.    Privacy    Terms of Use