Find information on medical topics, symptoms, drugs, procedures, news and more, written for the health care professional.

* This is the Professional Version. *

Overview of Vascular Bleeding Disorders

by David J. Kuter, MD, DPhil

Bleeding may result from abnormalities in platelets, coagulation factors, or blood vessels. Vascular bleeding disorders result from defects in blood vessels, typically causing petechiae, purpura, and bruising but, except for hereditary hemorrhagic telangiectasia, seldom leading to serious blood loss. Bleeding may result from deficiencies of vascular and perivascular collagen in Ehlers-Danlos syndrome and in other rare hereditary connective tissue disorders (eg, pseudoxanthoma elasticum, osteogenesis imperfecta, Marfan syndrome—see Marfan Syndrome). Hemorrhage may be a prominent feature of scurvy (see Vitamin C Deficiency) or of Henoch-Schönlein purpura, a hypersensitivity vasculitis common during childhood (see Immunoglobulin A–Associated Vasculitis (IgAV)). In vascular bleeding disorders, tests of hemostasis are usually normal. For most disorders, diagnosis is clinical; specific tests are available for some.

* This is a professional Version *