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Overview of Iron Overload

(Hemosiderosis; Hemochromatosis)

by Candido E. Rivera, MD

(For iron poisoning, see Iron Poisoning; for idiopathic pulmonary hemosiderosis, see Diffuse Alveolar Hemorrhage.)

Typical adults lose about 1 mg iron (Fe) per day in shed epidermal and GI cells; menstruating females lose on average an additional 0.5 to 1 mg/day from menses. This iron loss is balanced by absorption of a portion of the 10 to 20 mg of iron in a typical US diet. Iron absorption is regulated based on the body's iron stores and is usually in balance with the body's needs. However, because there is no physiologic mechanism to remove iron from the body, iron absorbed in excess of bodily needs (or acquired through repeated transfusion) is deposited in tissues:

  • Hemosiderosis is focal deposition of iron that does not cause tissue damage.

  • Hemochromatosis (iron overload) is a typically systemic process in which iron deposition can cause tissue damage.

Iron overload may result from hereditary hemochromatosis (a genetic disorder of iron metabolism) or from secondary hemochromatosis, which is an acquired form of the disease that is due to excess oral intake or absorption of iron, or to repeated blood transfusions. Morbidity is mainly due to iron accumulation in the endocrine organs (especially the pancreas, gonads, and pituitary), liver, and heart.

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