Not Found

Find information on medical topics, symptoms, drugs, procedures, news and more, written for the health care professional.

* This is the Professional Version. *

Prothrombin 20210 (Factor II) Gene Mutation

By Joel L. Moake, MD

Click here for
Patient Education

A genetic mutation causes increased serum levels of prothrombin (factor II), predisposing to venous thrombosis (see Overview of Thrombotic Disorders).

Prothrombin (factor II) is a vitamin K-dependent precursor of thrombin, the end-product of the coagulation cascade. A mutation of the prothrombin 20210 gene results in increased plasma prothrombin levels and increases the risk of venous thromboembolism. The prevalence of the mutation ranges from < 1% to 6.5%, depending on the population studied.

The diagnosis is made by genetic analysis of the prothrombin 20210 gene using blood samples.


  • Anticoagulation

Anticoagulation with heparin or low molecular weight heparin, followed by warfarin, is used for venous thrombosis, or for prophylaxis in patients at increased thrombotic risk (eg, by immobilization, severe injury, or surgery). It is not known if the newer oral anticoagulants that inhibit either thrombin (dabigatran) or factor Xa (eg, rivaroxaban, apixaban) can be used in place of other anticoagulants for this disorder.

Drugs Mentioned In This Article

  • Drug Name
    Select Trade

* This is the Professional Version. *