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Bleeding may result from abnormalities in platelets, coagulation factors, or blood vessels. Vascular bleeding disorders result from defects in blood vessels, typically causing petechiae, purpura, and bruising but seldom leading to serious blood loss. Bleeding may result from deficiencies of vascular and perivascular collagen in Ehlers-Danlos syndrome and in other rare hereditary connective tissue disorders (eg, pseudoxanthoma elasticum, osteogenesis imperfecta, Marfan syndrome—see Connective Tissue Disorders in Children: Marfan Syndrome). Hemorrhage may be a prominent feature of scurvy (see Vitamin Deficiency, Dependency, and Toxicity: Vitamin C Deficiency) or of Henoch-Schönlein purpura, a hypersensitivity vasculitis common during childhood (see Vasculitis: Henoch-Schönlein Purpura (HSP)). In vascular bleeding disorders, tests of hemostasis are usually normal. Diagnosis is clinical.
Last full review/revision April 2009 by James N. George, MD
Content last modified April 2009
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