Inborn Metabolic Disorders Causing Hyperbilirubinemia
Hereditary or inborn metabolic disorders may cause unconjugated or conjugated hyperbilirubinemia.
Dubin-Johnson syndrome and Rotor syndrome cause conjugated hyperbilirubinemia, but without cholestasis, causing no symptoms or sequelae other than jaundice. In contrast to unconjugated hyperbilirubinemia in Gilbert syndrome (which also causes no other symptoms), bilirubin may appear in the urine. Aminotransferase and alkaline phosphatase levels are usually normal. Treatment is unnecessary.