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  • Cardiovascular Disorders
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  • Eye Disorders
  • Gastrointestinal Disorders
  • Genitourinary Disorders
  • Geriatrics
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  • Hepatic and Biliary Disorders
  • Immunology; Allergic Disorders
  • Infectious Diseases
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  • Special Subjects
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  • Abdominal Pain, Acute
  • Abdominal pain, Chronic
  • Alopecia
  • Amenorrhea
  • Amnesia
  • Anosmia
  • Bleeding, Excessive
  • Breast Lumps
  • Chest Pain
  • Constipation in Adults
  • Constipation in Children
  • Cough in Adults
  • Cough in Children
  • Crying
  • Diarrhea in Adults
  • Diarrhea in Children
  • Diplopia
  • Dizziness
  • Dry Mouth
  • Dysmenorrhea
  • Dyspepsia
  • Dysphagia
  • Dyspnea
  • Dysuria
  • Earache
  • Ear Discharge
  • Edema
  • Edema During Late Pregnancy
  • Epistaxis
  • Erectile dysfunction
  • Eyelid Swelling
  • Eye Pain
  • Fever
  • Fever, Acute, in Adults
  • Fever, Chronic (FUO)
  • Fever in Infants and Children
  • Floaters
  • Gas
  • Gastrointestinal Bleeding
  • Halitosis
  • Headache
  • Hearing Loss
  • Hearing Loss: Sudden Deafness
  • Hematospermia
  • Hematuria
  • Hemoptysis
  • Hiccups
  • Hirsutism
  • Insomnia and Excessive Daytime Sleepiness
  • Itching
  • Itching, Anal
  • Jaundice in Adults
  • Jaundice in Neonates
  • Joint Pain, Monarticular
  • Joint Pain, Polyarticular
  • Knee pain
  • Lump in Throat
  • Nasal Congestion and Rhinorrhea
  • Nausea and Vomiting During Early pPregnancy
  • Nausea and Vomiting in Adults
  • Nausea and Vomiting in Infants and Children
  • Neck and Back Pain
  • Neck Mass
  • Nipple Discharge
  • Orthostatis Hypotension
  • Pain
  • Pain, Chronic
  • Palpitations
  • Pelvic Pain
  • Pelvic Pain During Early Pregnancy
  • Polyuria
  • Priapism
  • Red Eye
  • Scrotal Pain
  • Sore Throat
  • Stomatitis
  • Stridor
  • Syncope
  • Tearing
  • Tinnitus
  • Toothache
  • Tremor
  • Urinary Frequency
  • Urinary Incontinence in Adults
  • Urinary Incontinence in Children
  • Urinary Retention
  • Urticaria
  • Vaginal Bleeding
  • Vaginal Bleeding During Early Pregnancy
  • Vaginal Bleeding During Late Pregnancy
  • Vaginal Itching and Discharge
  • Vision, Blurred
  • Vision Loss, Acute
  • Weakness, Generalized
  • Wheezing
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Index
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Dracunculiasis

Dracunculiasis

Drainage

  • abscess

  • Abscesses: Treatment

  • postural

  • Pulmonary Rehabilitation

    Dressings

    Principles of Topical Dermatologic Therapy: Nonocclusive dressings

  • for burns

  • Burns: Initial wound care

  • Jones

  • Fractures, Dislocations, and Sprains: RICE

  • for pressure ulcers

  • Pressure Ulcers: Direct ulcer care
    Options for Pressure Ulcer DressingsTables

    Dressler's syndrome

    Acute Coronary Syndromes (ACS): Symptoms and Signs
    Pericarditis: Etiology
    Pericarditis: Acute pericarditis
    Pericarditis: Treatment

    Driving

    Prevention of Injuries in the Elderly: Driving hazards
    The Older Driver
    Number of crashes per licensed driver by age (2003).Figures
    Annual mileage by age and sex (2001).Figures

    Dronabinol

    Management of Adverse Effects of Cancer Therapy: Nausea and Vomiting
    Marijuana (Cannabis)

  • in anorexia

  • Protein-Energy Undernutrition: Adults

    Dronedarone

    Antiarrhythmic Drugs (Vaughan Williams Classification) Tables

    Drop-arm test

    Examination for Some Commonly Missed InjuriesTables

    Drospirenone

    Contraception: Adverse effects

    Drotrecogin alfa

    Sepsis and Septic Shock: Treatment

    Drowning

    Drowning

  • cardiopulmonary resuscitation in

  • Cardiopulmonary Resuscitation (CPR) in Adults: Special Circumstances

    Drug dependence (abuse, addiction, habituation)

    Drug Use and Dependence

  • benign transient amnesia and

  • Amnesias: Transient Global Amnesia

  • breastfeeding and

  • Some Drugs Contraindicated for Breastfeeding MothersTables

  • in children and adolescents

  • Approach to the Care of Adolescents: Psychosocial Disorders
    Substance Use in Children and Adolescents

  • depression and

  • Depressive Disorders: Etiology
    Depressive Disorders: Treatment

  • development of

  • Drug Dependence

  • in elderly

  • Evaluation of the Elderly Patient: Alcohol, tobacco, and recreational drug use history

  • neonatal withdrawal and

  • Prenatal Drug Exposure

  • pregnancy and

  • Drugs in Pregnancy: Social and Illicit Drugs
    Prenatal Drug Exposure

  • psychosis and

  • Substance-Induced Psychotic Disorder

  • schizophrenia and

  • Schizophrenia: Prognosis

  • seizures and

  • Seizure Disorders: Treatment

  • surgery and

  • Perioperative Management: Drug dependence

  • testing for

  • Drug Testing

  • undernutrition and

  • Undernutrition: Alcohol or drug dependency

    Drugs

    Concepts in Pharmacotherapy

  • absorption of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Absorption

  • in children

  • Pharmacokinetics in Children: Absorption

  • rate of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Representative plasma concentration–time relationship after a single oral dose of a hypothetical drug.Figures
    Drug Bioavailability: Assessing bioavailability

  • abuse of

  • see also Drug dependence (abuse, addiction, habituation)
    Drug Use and Dependence: Definitions

  • active transport of

  • Drug Absorption: Active transport

  • addiction to

  • see also Drug dependence (abuse, addiction, habituation)
    Drug Use and Dependence: Definitions

  • adherence to

  • Adherence to a Drug Regimen
    Causes of NonadherenceTables

  • in children

  • Nonadherence in Children
    Adherence to a Drug Regimen

  • in elderly

  • Adherence to a Drug Regimen
    Drug-Related Problems in the Elderly: Lack of patient adherence

  • administration of

  • oral

  • Drug Absorption: Oral Administration

  • parenteral

  • Drug Absorption: Parenteral Administration

  • adverse reactions to

  • Adverse Drug Reactions
    Classification of Adverse Drug ReactionsTables

  • benefits vs

  • Efficacy and Safety: Balancing Benefits and Adverse Effects

  • in children

  • Principles of Drug Treatment in Children: Adverse effects and toxicity
    Drugs Manifesting Unusual Toxicity in ChildrenTables

  • in elderly

  • Drug-Related Problems in the Elderly
    Preventable Causes of Drug-Related ProblemsTables
    High-Risk Drugs in the Elderly (Based on the Beers Criteria)Tables
    Hospital Care and the Elderly: Adverse Drug Effects

  • agonist

  • Drug-Receptor Interactions: Agonists and antagonists

  • allergy to

  • Drug Hypersensitivity
    Adverse Drug Reactions: Etiology

  • antagonist

  • Drug-Receptor Interactions: Agonists and antagonists

  • antidotes for

  • Common Specific AntidotesTables

  • apparent volume of distribution of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Distribution to Tissues: Volume of distribution

  • area under concentration curve for

  • Representative plasma concentration–time relationship after a single oral dose of a hypothetical drug.Figures

  • bezoars with

  • Bezoars and Foreign Bodies

  • bioavailability of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Bioavailability
    Representative plasma concentration–time relationship after a single oral dose of a hypothetical drug.Figures

  • low

  • Drug Bioavailability: Causes of low bioavailability

  • bioequivalence of

  • Drug Bioavailability

  • blood-brain barrier and

  • Drug Distribution to Tissues: Blood-brain barrier

  • body packing and

  • Body Packing

  • breastfeeding and

  • Nutrition in Infants: Drugs
    Some Drugs Contraindicated for Breastfeeding MothersTables

  • carcinogenicity of

  • Common Chemical CarcinogensTables

  • chemical equivalence of

  • Drug Bioavailability

  • chemical interactions of

  • Chemical Interactions

  • in children

  • Principles of Drug Treatment in Children
    Drugs Manifesting Unusual Toxicity in ChildrenTables
    Changes in body proportions of body composition with growth and aging. Figures

  • clearance of

  • see also Drugs, excretion of
    Formulas Defining Basic Pharmacokinetic ParametersTables
    Pharmacokinetics in the Elderly: Hepatic metabolism

  • conjugation of

  • Drug Metabolism: Conjugation

  • controlled

  • Drug Use and Dependence: Narcotics and scheduled drugs
    Some Examples of Controlled SubstancesTables

  • controlled-release forms of

  • Drug Absorption: Controlled-Release Forms

  • cutaneous reactions to

  • Drug Eruptions and Reactions
    Types of Drug Reactions and Typical Causative AgentsTables
    Drug Hypersensitivity

  • dermatitis and

  • Principles of Topical Dermatologic Therapy: Anti-inflammatory agents
    Contact Dermatitis
    Causes of Allergic Contact DermatitisTables

  • erythema multiforme and

  • Causes of Allergic Contact DermatitisTables
    Causes of Allergic Contact DermatitisTables
    Erythema Multiforme

  • hyperpigmentation and

  • Hyperpigmentation: Drug-induced hyperpigmentation
    Hyperpigmentation Effects of Some Drugs and ChemicalsTables

  • ichthyosis and

  • Ichthyosis: Acquired ichthyosis

  • lichen planus and

  • Lichen Planus: Etiology
    Types of Drug Reactions and Typical Causative AgentsTables

  • photosensitivity and

  • Photosensitivity: Chemical photosensitivity
    Some Substances That Sensitize the Skin to SunlightTables
    Types of Drug Reactions and Typical Causative AgentsTables

  • Stevens-Johnson syndrome and

  • Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

  • toxic epidermal necrolysis and

  • Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)
    Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN)Tables

  • cytochrome P-450 enzyme interaction with

  • Drug Metabolism: Cytochrome P-450
    Common Substances That Interact With Cytochrome P-450 Enzymes Tables

  • delirium and

  • Causes of DeliriumTables

  • dementia and

  • Dementia: Etiology
    Pharmacodynamics in the Elderly

  • dental discoloration with

  • Evaluation of the Dental Patient: Physical examination

  • depression and

  • Depressive Disorders: Etiology
    Depressive Disorders: Treatment

  • desensitization to

  • Drug Hypersensitivity: Desensitization

  • development of

  • Drug Development

  • dietary supplement interactions with

  • Some Possible Dietary Supplement–Drug Interactions*Tables

  • diffusion of

  • Drug Absorption: Passive diffusion

  • disease interactions with

  • Pharmacodynamics
    Drug-Related Problems in the Elderly: Drug-disease interactions
    Drug-Disease Interactions in the ElderlyTables

  • dissolution rate of

  • Drug Absorption: Oral Administration

  • distribution of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Distribution to Tissues

  • in children

  • Pharmacokinetics in Children: Distribution
    Changes in body proportions of body composition with growth and aging. Figures

  • in elderly

  • Pharmacokinetics in the Elderly: Distribution

  • dose-response relationships of

  • Dose-Response Relationships
    Hypothetical dose-response curve.Figures

  • dosing for

  • in children

  • Pharmacokinetics in Children: Drug dosing

  • driving and

  • Medical Assessment of the Older Driver: Drugs

  • during pregnancy

  • Drugs in Pregnancy
    FDA Categories of Drug Safety During PregnancyTables
    Some Drugs With Adverse Effects During PregnancyTables
    Infectious Disease in Pregnancy: Antibacterials
    Risk Factors for Complications During Pregnancy: Exposure to teratogens

  • efficacy of

  • Efficacy and Safety

  • elimination of

  • see Drugs, excretion of

  • elimination rate constant of

  • Formulas Defining Basic Pharmacokinetic ParametersTables

  • endoscopy and

  • Endoscopy

  • equilibrium state of

  • Drug Distribution to Tissues

  • errors in

  • Drug Errors

  • excretion of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Excretion

  • biliary

  • Drug Excretion: Biliary excretion

  • bioavailability and

  • Drug Bioavailability: Assessing bioavailability

  • in children

  • Pharmacokinetics in Children: Metabolism and elimination

  • in elderly

  • Pharmacokinetics in the Elderly: Renal elimination
    Effect of Aging on Drug Metabolism* and EliminationTables

  • hepatic

  • Formulas Defining Basic Pharmacokinetic ParametersTables

  • renal

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Bioavailability: Assessing bioavailability
    Drug Excretion: Renal excretion
    Pharmacokinetics in the Elderly: Renal elimination
    Effect of Aging on Drug Metabolism* and EliminationTables

  • exercise and

  • ExerciseSidebars

  • falls and

  • Some Drugs That Contribute to Risk of FallsTables

  • gastroenteritis and

  • Drug- and Chemical-Related Gastroenteritis

  • glucuronidation of

  • Drug Metabolism: Conjugation

  • gynecomastia and<italic>

  • Common Drug Causes of Gynecomastia*Tables

  • half-life of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Pharmacokinetics
    Comparison of pharmacokinetic outcomes for diazepam in a younger man (A) and an older man (B). Figures
    Drug Metabolism: Rate

  • heatstroke-like syndrome with

  • Heatstroke

  • hemolysis and

  • Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: Pathophysiology

  • hepatic metabolism of

  • see Drugs, metabolism of

  • hepatotoxicity of

  • Liver Injury Caused by Drugs
    Potentially Hepatotoxic DrugsTables

  • hypersensitivity reactions to

  • Drug Hypersensitivity
    Adverse Drug Reactions: Etiology

  • anaphylaxis and

  • Anaphylaxis

  • idiosyncratic reactions to

  • Adverse Drug Reactions: Etiology
    Adverse Drug Reactions: Treatment

  • immunodeficiency with

  • Some Drugs That Cause ImmunosuppressionTables

  • inhalational forms of

  • in children

  • Pharmacokinetics in Children: Absorption

  • interactions of

  • see also specific drugs
    Drug Interactions
    Some Drugs With Potentially Serious Drug-Drug Interactions*Tables
    Common Substances That Interact With Cytochrome P-450 Enzymes Tables

  • antagonistic

  • Drug-Receptor Interactions: Agonists and antagonists

  • chemical

  • Chemical Interactions

  • in elderly

  • Drug-Related Problems in the Elderly
    Preventable Causes of Drug-Related ProblemsTables

  • receptor-related

  • Drug-Receptor Interactions: Agonists and antagonists

  • intrinsic efficacy of

  • Drug-Receptor Interactions

  • malignant hyperthermia with

  • Malignant Hyperthermia

  • maximum (peak) concentration of

  • Representative plasma concentration–time relationship after a single oral dose of a hypothetical drug.Figures
    Drug Bioavailability: Assessing bioavailability

  • MedWatch for

  • Adverse Drug Reactions: Diagnosis

  • membrane transport of

  • Drug Absorption
    Drug Excretion: Renal excretion

  • metabolism of

  • Some Drugs With Potentially Serious Drug-Drug Interactions*Tables
    Pharmacogenetics
    Examples of Pharmacogenetic VariationsTables
    Drug Metabolism
    Common Substances That Interact With Cytochrome P-450 Enzymes Tables

  • biologic variation in

  • Dose-Response Relationships

  • in children

  • Pharmacokinetics in Children: Metabolism and elimination
    Drug Metabolism: Cytochrome P-450

  • conjugation in

  • Drug Metabolism: Conjugation

  • cytochrome P-450 and

  • Drug Metabolism: Cytochrome P-450
    Common Substances That Interact With Cytochrome P-450 Enzymes Tables

  • in elderly

  • Pharmacokinetics
    Comparison of pharmacokinetic outcomes for diazepam in a younger man (A) and an older man (B). Figures
    Drug Metabolism: Cytochrome P-450
    Pharmacokinetics in the Elderly: Hepatic metabolism
    Effect of Aging on Drug Metabolism* and EliminationTables

  • glucuronidation in

  • Drug Metabolism: Conjugation

  • hepatic

  • Effects of Liver Disease on Drug Metabolism

  • liver disease and

  • Effects of Liver Disease on Drug Metabolism

  • rate of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Metabolism
    Drug Metabolism: Rate

  • nail discoloration and

  • Nail Deformities: Discoloration

  • nephrotoxicity of

  • Acute Tubular Necrosis (ATN)
    Laboratory Findings Distinguishing Acute Tubular Necrosis From Prerenal AzotemiaTables
    Causes of Acute Tubulointerstitial NephritisTables
    Causes of Chronic Tubulointerstitial NephritisTables
    Fanconi Syndrome: Acquired Fanconi syndrome

  • nonadherence to

  • Adherence to a Drug Regimen
    Causes of NonadherenceTables

  • in children

  • Nonadherence in Children
    Adherence to a Drug Regimen

  • in elderly

  • Adherence to a Drug Regimen
    Drug-Related Problems in the Elderly: Lack of patient adherence

  • nutrient interactions with

  • Nutrient-Drug Interactions
    Effects of Some Drugs on NutritionTables
    Undernutrition: Drugs and nutritional supplements
    Potential Vitamin-Drug InteractionsTables

  • in obesity

  • Obesity and the Metabolic Syndrome: Drugs

  • oral administration of

  • Drug Absorption: Oral Administration

  • oral contraceptive interactions with

  • Contraception: Drug interactions

  • ototoxicity of

  • Some Causes of TinnitusTables
    Sudden Deafness: Etiology
    Drug-Induced Ototoxicity
    Some Drugs that Cause OtotoxicityTables

  • outdated

  • Drug Errors

  • parenteral administration of

  • Drug Absorption: Parenteral Administration

  • peak time of

  • Representative plasma concentration–time relationship after a single oral dose of a hypothetical drug.Figures
    Drug Bioavailability: Assessing bioavailability

  • perioperative

  • Perioperative Management

  • pharmacodynamics of

  • Pharmacodynamics
    Some Types of Physiologic and Drug-Receptor ProteinsTables

  • in elderly

  • Pharmacodynamics in the Elderly
    Effect of Aging on Drug ResponseTables

  • pharmacogenetics of

  • Pharmacogenetics
    Examples of Pharmacogenetic VariationsTables
    Genetic, environmental, and developmental factors that can interact, causing variations in drug response among patients.Figures

  • pharmacokinetics of

  • Pharmacokinetics
    Formulas Defining Basic Pharmacokinetic ParametersTables
    Comparison of pharmacokinetic outcomes for diazepam in a younger man (A) and an older man (B). Figures

  • in children

  • Pharmacokinetics in Children
    Changes in body proportions of body composition with growth and aging. Figures

  • in elderly

  • Comparison of pharmacokinetic outcomes for diazepam in a younger man (A) and an older man (B). Figures
    Pharmacokinetics in the Elderly

  • genetic factors in

  • Pharmacogenetics
    Examples of Pharmacogenetic VariationsTables
    Genetic, environmental, and developmental factors that can interact, causing variations in drug response among patients.Figures

  • pharmacologic profile of

  • Dose-Response Relationships
    Comparison of dose-response curves. Figures

  • pH effects on

  • Drug Absorption: Passive diffusion
    Drug Excretion: Renal excretion

  • physical dependence on

  • see also Drug dependence (abuse, addiction, habituation)
    Treatment of Pain: Opioid Analgesics
    Drug Use and Dependence: Definitions

  • pinocytosis of

  • Drug Absorption: Pinocytosis

  • pK a of

  • Drug Absorption: Passive diffusion

  • placebos and

  • Placebos

  • plasma concentration of

  • Representative plasma concentration–time relationship after a single oral dose of a hypothetical drug.Figures
    Drug Bioavailability: Assessing bioavailability

  • poisoning with

  • Acetaminophen Poisoning

  • porphyria and

  • Acute Porphyrias: Precipitating Factors
    Drugs and Porphyria*Tables

  • prescriptions for

  • Drug Errors

  • protein binding of

  • Drug Distribution to Tissues: Binding

  • in elderly

  • Pharmacokinetics in the Elderly: Distribution

  • provocation testing of

  • Drug Hypersensitivity: Other testing

  • psychologic dependence on

  • see also Drug dependence (abuse, addiction, habituation)
    Drug Use and Dependence: Definitions

  • pulmonary toxicity of

  • Drug-Induced Pulmonary Disease
    Substances With Toxic Pulmonary EffectsTables

  • receptor affinity of

  • Drug-Receptor Interactions

  • receptor interactions with

  • Drug-Receptor Interactions
    Some Types of Physiologic and Drug-Receptor ProteinsTables

  • recreational use of

  • Drug Use and Dependence: Definitions

  • renal excretion of

  • see Drugs, excretion of

  • resistance to

  • Tolerance and Resistance

  • risk-benefit analysis of

  • Efficacy and Safety: Balancing Benefits and Adverse Effects
    Adverse Drug Reactions

  • safety of

  • Efficacy and Safety

  • seizures and

  • Causes of SeizuresTables
    Seizure Disorders: Treatment

  • side effects of

  • see Drugs, adverse reactions to

  • skin testing of

  • Drug Hypersensitivity: Skin testing

  • storage of

  • Drug Errors

  • syncope and

  • Some Drug Causes of SyncopeTables

  • teratogenicity of

  • Drugs in Pregnancy
    FDA Categories of Drug Safety During PregnancyTables
    Some Drugs With Adverse Effects During PregnancyTables
    Cancer in Pregnancy
    Risk Factors for Complications During Pregnancy: Exposure to teratogens
    Intellectual Disability (ID): Prenatal

  • therapeutic equivalence of

  • Drug Bioavailability

  • therapeutic index of

  • Efficacy and Safety: Therapeutic index
    Drug Bioavailability
    Dose-Response Relationships

  • thrombocytopenia and

  • Thrombocytopenia: Other Causes: Drug-induced immunologic destruction

  • thyroxine levels and

  • Thyroid Disorders: Laboratory Testing of Thyroid Function
    Euthyroid Sick Syndrome

  • tissue accumulation of

  • Drug Distribution to Tissues: Binding

  • tolerance to

  • Tolerance and Resistance
    Drug Use and Dependence: Definitions

  • topical

  • Principles of Topical Dermatologic Therapy
    Relative Potency of Selected Topical Corticosteroids Tables

  • dermatitis with

  • Causes of Allergic Contact DermatitisTables

  • toxicity of

  • Adverse Drug Reactions

  • toxidromes with

  • Common Toxic Syndromes (Toxidromes)Tables

  • trade names for

  • Trade Names of Some Commonly Used Drugs

  • transdermal forms of

  • Pharmacokinetics in Children: Absorption
    Drug Absorption: Controlled-Release Forms

  • transrectal forms of

  • Pharmacokinetics in Children: Absorption

  • tremor and

  • Tremor: Pathologic (nonphysiologic) tremorTables

  • volume of distribution of

  • Formulas Defining Basic Pharmacokinetic ParametersTables
    Drug Distribution to Tissues: Volume of distribution

  • withdrawal from

  • Causes of SeizuresTables
    Drug Use and Dependence: Definitions

  • insomnia and

  • Some Drugs That Interfere With SleepTables
    Insomnia and Excessive Daytime Sleepiness (EDS): Drug-related sleep disorders

    Drusen

    Evaluation of the Ophthalmologic Patient: Ophthalmoscopy
    Retinal Disorders: Pathophysiology

    Dry eyes

    Keratoconjunctivitis Sicca

    Drying agents

    Principles of Topical Dermatologic Therapy: Drying agents

    Dry skin

    Some Causes of ItchingTables
    Xeroderma

    Dry socket

    Postextraction Problems: Alveolitis and osteomyelitis

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